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Revisited Synthesis of Aryl-H-phosphinates
Journal article   Peer reviewed

Revisited Synthesis of Aryl-H-phosphinates

Jean-Noël Volle, Damien Filippini, Camille Midrier, Michal Sobecki, Marcin Drag, David Virieux and Jean-Luc Pirat
Synthesis: Journal of Synthetic Organic Chemistry, Vol.15, pp.2490-2494
14/07/2011

Abstract

phosphonites phosphinates aryl-H-phosphinates triethyl phosphite hydrolysis Grignard reagent
A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petneházy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-Hphosphinates in high yields and purities.
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