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Review Article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up
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Review Article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up

V Lejon et P Büscher
Tropical medicine & international health, Vol.10(5), pp.395-403
05/2005
DOI: https://doi.org/10.1111/j.1365-3156.2005.01403.x
PMID: 15860085

Résumé

Animals Central Nervous System Infections - cerebrospinal fluid Central Nervous System Infections - diagnosis Central Nervous System Infections - drug therapy Decision Making Humans Immunoglobulins - analysis Trypanosoma brucei gambiense - isolation & purification Trypanosoma brucei rhodesiense - isolation & purification Trypanosomiasis, African - cerebrospinal fluid Trypanosomiasis, African - diagnosis Trypanosomiasis, African - drug therapy
Human African trypanosomiasis is a lethal parasitic infection with neurological involvement. Examination of the cerebrospinal fluid (CSF) plays an essential role in diagnosis, selection of treatment and post-treatment follow-up. This paper reviews clinical presentation, diagnosis and treatment of the disease, with emphasis on CSF characteristics and interpretation of the CSF results for therapeutic decision and post-treatment follow-up.

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