Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy

M. Steinberg; L. Swainson; K. Schwarz; M. Boyer; W. Friedrich; H. Yssel; N. Taylor; N. Noraz

doi:10.1038/sj.gt.3301249

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Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy

Journal article

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Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy

M. Steinberg, L. Swainson, K. Schwarz, M. Boyer, W. Friedrich, H. Yssel, N. Taylor and N. Noraz

Gene Therapy, Vol.7(16), pp.1392--400

2000

DOI: https://doi.org/10.1038/sj.gt.3301249

Abstract

T-Cell/metabolism Retroviridae/*genetics Signal Transduction T-Lymphocytes/*enzymology/metabolism ZAP-70 Protein-Tyrosine Kinase

Cell Division Consanguinity Gene Therapy/*methods Gene Transfer Techniques Genetic Vectors/*administration & dosage Humans Immunoblotting Infant Interleukin-2/secretion MAP Kinase Signaling System Protein-Tyrosine Kinases/*deficiency/*genetics Receptors

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Title: Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy
Creators - without role: M. Steinberg - Institut de Génétique Moléculaire de Montpellier
L. Swainson - Institut de Génétique Moléculaire de Montpellier
K. Schwarz - Universität Ulm
M. Boyer - Centre National de la Recherche Scientifique
W. Friedrich - Universität Ulm
H. Yssel - Inserm
N. Taylor - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
N. Noraz - Institut de Génétique Moléculaire de Montpellier
Publication Details: Gene Therapy, Vol.7(16), pp.1392--400
Identifiers: 9945891009311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-02196834