Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Luis Felipe Reyes; Srinivas Murthy; Esteban Garcia-Gallo; Laura Merson; Elsa D Ibáñez-Prada; Jordi Rello; Yuli V Fuentes; Ignacio Martin-Loeches; Fernando Bozza; Sara Duque; Fabio S Taccone; Robert A Fowler; Christiana Kartsonaki; Bronner P Gonçalves; Barbara Wanjiru Citarella; Diptesh Aryal; Erlina Burhan; Matthew J Cummings; Christelle Delmas; Rodrigo Diaz; Claudia Figueiredo-Mello; Madiha Hashmi; Prasan Kumar Panda; Miguel Pedrera Jiménez; Diego Fernando Bautista Rincon; David Thomson; Alistair Nichol; John C Marshall; Piero L Olliaro; Ali Abbas; Sheryl Ann Abdukahil; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Eman Al Qasim; Razi Alalqam; Tala Al-dabbous; Senthilkumar Alegesan; Cynthia Alegre; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Naseem Ali Shah; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Aneela Altaf; João Alves; João Melo Alves; Rita Alves; Joana Alves Cabrita; Maria Amaral; Phoebe Ampaw; Roberto Andini; Claire Andréjak; Andrea Angheben; François Angoulvant; Séverine Ansart; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Angel Asensio; Namra Asif; Mohammad Asim; Jean Baptiste Assie; Anika Atique; A. M. Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J. Kenneth Baillie; Erica Bak; Agamemnon Bakakos; Andriy Bal; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Wendy S Barclay; Michaela Barnikel; Helena Barrasa; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Joaquín Baruch; Romain Basmaci; Denise Battaglini; Jules Bauer; Denisse Bazan Dow; Abigail Beane; Alexandra Bedossa; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Marine Beluze; Nicolas Benech; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Moirangthem Bikram Singh; Felwa Bin Humaid; François Bissuel; Laurent Bitker; Jonathan Bitton; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Debby Bogaert; Anne-Hélène Boivin; Pierre-Adrien Bolze; François Bompart; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Bianca Boxma; Marielle Boyer-Besseyre; Maria Boylan; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Dorothy Breen; Patrick Breen; Kathy Brickell; Alex Browne; Shaunagh Browne; Marjolein Brusse-Keizer; Nina Buchtele; Christian Buesaquillo; Polina Bugaeva; Marielle Buisson; Aidan Burrell; Ingrid G Bustos; Denis Butnaru; André Cabie; Susana Cabral; Eder Caceres; Cyril Cadoz; Rui Caetano Garcês; Kate Calligy; Jose Andres Calvache; João Camões; Valentine Campana; Paul Campbell; Cecilia Canepa; Mireia Cantero; Pauline Caraux-Paz; Sheila Cárcel; Chiara Simona Cardellino; Filipa Cardoso; Filipe Cardoso; Nelson Cardoso; Sofia Cardoso; Simone Carelli; Nicolas Carlier; Thierry Carmoi; 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Azhari Taufik; Hassan Tawfik; Richard S Tedder; João Teixeira; Sofia Tejada; Marie-Capucine Tellier; François Téoulé; Pleun Terpstra; Olivier Terrier; Nicolas Terzi; Hubert Tessier-Grenier; Adrian Tey; Anand Thakur; Vincent Thibault; Simon-Djamel Thiberville; Benoît Thill; Shaun Thompson; Emma C Thomson; Ryan S Thwaites; Paul Tierney; Vadim Tieroshyn; Peter S Timashev; Jean-François Timsit; Noémie Tissot; Maria Toki; Kristian Tonby; Marta Torre; Antoni Torres; Margarida Torres; Hernando Torres-Zevallos; Michael Towers; Tony Trapani; Théo Treoux; Cécile Tromeur; Ioannis Trontzas; Tiffany Trouillon; Jeanne Truong; Christelle Tual; Sarah Tubiana; Helen Tuite; Jean-Marie Turmel; Lance C. W Turtle; Pawel Twardowski; Makoto Uchiyama; P. G. Ishara Udayanga; Andrew Udy; Roman Ullrich; Alberto Uribe; Asad Usman; Timothy M Uyeki; Cristinava Vajdovics; Luís Val-Flores; Amélie Valran; Stijn Van de Velde; Marcel van den Berge; Job van der Palen; Paul van der Valk; Nicky Van Der Vekens; Peter Van der Voort; Sylvie Van Der Werf; Laura van Gulik; Jarne Van Hattem; Carolien van Netten; Ilonka van Veen; Noémie Vanel; Henk Vanoverschelde; Pooja Varghese; Charline Vauchy; Aurélie Veislinger; Sebastian Vencken; Sara Ventura; Annelies Verbon; James Vickers; José Ernesto Vidal; César Vieira; Deepak Vijayan; Joy Ann Villanueva; Judit Villar; Pierre-Marc Villeneuve; Andrea Villoldo; Benoit Visseaux; Hannah Visser; Chiara Vitiello; Harald Vonkeman; Fanny Vuotto; Wan Fadzlina Wan Muhd Shukeri; Chih-Hsien Wang; Steve Webb; Jia Wei; Katharina Weil; Sanne Wesselius; T. Eoin West; Murray Wham; Bryan Whelan; Nicole White; Paul Henri Wicky; Aurélie Wiedemann; Surya Otto Wijaya; Keith Wille; Suzette Willems; Virginie Williams; Evert-Jan Wils; Ng Wing Yiu; Calvin Wong; Ioannis Xynogalas; Masaki Yamazaki; Yazdan Yazdanpanah; Cécile Yelnik; Stephanie Yerkovich; Toshiki Yokoyama; Hodane Yonis; Obada Yousif; Saptadi Yuliarto; Akram Zaaqoq; Marion Zabbe; Maram Zahran; Maria Zambon; Alberto Zanella; Hiba Zayyad; Alexander Zoufaly; David Zucman

doi:10.1186/s13054-022-04155-1

Article de revue

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson, Elsa D Ibáñez-Prada, Jordi Rello, Yuli V Fuentes, Ignacio Martin-Loeches, Fernando Bozza, Sara Duque, …

12/2022

DOI: https://doi.org/10.1186/s13054-022-04155-1

Résumé

Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality.

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Titre: Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Créateurs - sans rôle: Luis Felipe Reyes
Srinivas Murthy
Esteban Garcia-Gallo
Laura Merson
Elsa D Ibáñez-Prada
Jordi Rello
Yuli V Fuentes
Ignacio Martin-Loeches
Fernando Bozza
Sara Duque
Fabio S Taccone
Robert A Fowler
Christiana Kartsonaki
Bronner P Gonçalves
Barbara Wanjiru Citarella
Diptesh Aryal
Erlina Burhan
Matthew J Cummings
Christelle Delmas
Rodrigo Diaz
Claudia Figueiredo-Mello
Madiha Hashmi
Prasan Kumar Panda
Miguel Pedrera Jiménez
Diego Fernando Bautista Rincon
David Thomson
Alistair Nichol
John C Marshall
Piero L Olliaro
Ali Abbas
Sheryl Ann Abdukahil
Ryuzo Abe
Laurent Abel
Lara Absil
Subhash Acharya
Andrew Acker
Diana Adrião
Saleh Al Ageel
Shakeel Ahmed
Kate Ainscough
Tharwat Aisa
Ali Ait Hssain
Younes Ait Tamlihat
Takako Akimoto
Ernita Akmal
Eman Al Qasim
Razi Alalqam
Tala Al-dabbous
Senthilkumar Alegesan
Cynthia Alegre
Marta Alessi
Beatrice Alex
Kévin Alexandre
Abdulrahman Al-Fares
Huda Alfoudri
Imran Ali
Naseem Ali Shah
Kazali Enagnon Alidjnou
Jeffrey Aliudin
Qabas Alkhafajee
Clotilde Allavena
Nathalie Allou
Aneela Altaf
João Alves
João Melo Alves
Rita Alves
Joana Alves Cabrita
Maria Amaral
Phoebe Ampaw
Roberto Andini
Claire Andréjak
Andrea Angheben
François Angoulvant
Séverine Ansart
Massimo Antonelli
Carlos Alexandre Antunes de Brito
Ardiyan Apriyana
Yaseen Arabi
Irene Aragao
Carolline Araujo
Antonio Arcadipane
Patrick Archambault
Lukas Arenz
Jean-Benoît Arlet
Christel Arnold-Day
Lovkesh Arora
Rakesh Arora
Elise Artaud-Macari
Angel Asensio
Namra Asif
Mohammad Asim
Jean Baptiste Assie
Anika Atique
A. M. Udara Lakshan Attanyake
Johann Auchabie
Hugues Aumaitre
Adrien Auvet
Laurène Azemar
Cecile Azoulay
Benjamin Bach
Delphine Bachelet
Claudine Badr
Nadia Baig
J. Kenneth Baillie
Erica Bak
Agamemnon Bakakos
Andriy Bal
Valeria Balan
Firouzé Bani-Sadr
Renata Barbalho
Wendy S Barclay
Michaela Barnikel
Helena Barrasa
Audrey Barrelet
Cleide Barrigoto
Marie Bartoli
Joaquín Baruch
Romain Basmaci
Denise Battaglini
Jules Bauer
Denisse Bazan Dow
Abigail Beane
Alexandra Bedossa
Husna Begum
Sylvie Behilill
Albertus Beishuizen
Aleksandr Beljantsev
David Bellemare
Anna Beltrame
Marine Beluze
Nicolas Benech
Dehbia Benkerrou
Suzanne Bennett
Luís Bento
Jan-Erik Berdal
Delphine Bergeaud
Hazel Bergin
José Luis Bernal Sobrino
Giulia Bertoli
Lorenzo Bertolino
Simon Bessis
Sybille Bevilcaqua
Karine Bezulier
Amar Bhatt
Krishna Bhavsar
Claudia Bianco
Moirangthem Bikram Singh
Felwa Bin Humaid
François Bissuel
Laurent Bitker
Jonathan Bitton
Pablo Blanco-Schweizer
Catherine Blier
Frank Bloos
Mathieu Blot
Filomena Boccia
Laetitia Bodenes
Debby Bogaert
Anne-Hélène Boivin
Pierre-Adrien Bolze
François Bompart
Diogo Borges
Raphaël Borie
Hans Martin Bosse
Elisabeth Botelho-Nevers
Lila Bouadma
Olivier Bouchaud
Sabelline Bouchez
Dounia Bouhmani
Damien Bouhour
Kévin Bouiller
Laurence Bouillet
Camile Bouisse
Anne-Sophie Boureau
John Bourke
Maude Bouscambert
Aurore Bousquet
Jason Bouziotis
Bianca Boxma
Marielle Boyer-Besseyre
Maria Boylan
Axelle Braconnier
Cynthia Braga
Timo Brandenburger
Filipa Brás Monteiro
Luca Brazzi
Dorothy Breen
Patrick Breen
Kathy Brickell
Alex Browne
Shaunagh Browne
Marjolein Brusse-Keizer
Nina Buchtele
Christian Buesaquillo
Polina Bugaeva
Marielle Buisson
Aidan Burrell
Ingrid G Bustos
Denis Butnaru
André Cabie
Susana Cabral
Eder Caceres
Cyril Cadoz
Rui Caetano Garcês
Kate Calligy
Jose Andres Calvache
João Camões
Valentine Campana
Paul Campbell
Cecilia Canepa
Mireia Cantero
Pauline Caraux-Paz
Sheila Cárcel
Chiara Simona Cardellino
Filipa Cardoso
Filipe Cardoso
Nelson Cardoso
Sofia Cardoso
Simone Carelli
Nicolas Carlier
Thierry Carmoi
Gayle Carney
Inês Carqueja
Marie-Christine Carret
François Martin Carrier
Ida Carroll
Gail Carson
Maire-Laure Casanova
Mariana Cascão
Siobhan Casey
José Casimiro
Bailey Cassandra
Silvia Castañeda
Nidyanara Castanheira
Guylaine Castor-Alexandre
Henry Castrillón
Ivo Castro
Ana Catarino
François-Xavier Catherine
Paolo Cattaneo
Roberta Cavalin
Giulio Giovanni Cavalli
Alexandros Cavayas
Adrian Ceccato
Minerva Cervantes-Gonzalez
Anissa Chair
Catherine Chakveatze
Adrienne Chan
Meera Chand
Christelle Chantalat Auger
Jean-Marc Chapplain
Julie Chas
Mobin Chaudry
Jonathan Samuel Chávez Iñiguez
Anjellica Chen
Yih-Sharng Chen
Matthew Pellan Cheng
Antoine Cheret
Thibault Chiarabini
Julian Chica
Catherine Chirouze
Davide Chiumello
Sung-Min Cho
Bernard Cholley
Marie-Charlotte Chopin
Jose Pedro Cidade
José Miguel Cisneros Herreros
Anna Ciullo
Emma Clarke
Jennifer Clarke
Sara Clohisey
Perren J Cobb
Cassidy Codan
Caitriona Cody
Alexandra Coelho
Megan Coles
Gwenhaël Colin
Michael Collins
Sebastiano Maria Colombo
Pamela Combs
Marie Connor
Anne Conrad
Sofía Contreras
Elaine Conway
Graham S Cooke
Mary Copland
Hugues Cordel
Amanda Corley
Sabine Cornelis
Alexander Daniel Cornet
Arianne Joy Corpuz
Andrea Cortegiani
Grégory Corvaisier
Emma Costigan
Camille Couffignal
Sandrine Couffin-Cadiergues
Roxane Courtois
Stéphanie Cousse
Rachel Cregan
Sabine Croonen
Gloria Crowl
Jonathan Crump
Claudina Cruz
Juan Luis Cruz Bermúdez
Jaime Cruz Rojo
Marc Csete
Ailbhe Cullen
Ger Curley
Elodie Curlier
Colleen Curran
Paula Custodio
Ana da Silva Filipe
Charlene Da Silveira
Al-Awwab Dabaliz
Andrew Dagens
Darren Dahly
Heidi Dalton
Jo Dalton
Seamus Daly
Juliana Damas
Nick Daneman
Corinne Daniel
Emmanuelle A Dankwa
Jorge Dantas
Frédérick D’Aragon
Gillian de Loughry
Diego de Mendoza
Etienne De Montmollin
Rafael Freitas de Oliveira França
Ana Isabel de Pinho Oliveira
Rosanna De Rosa
Thushan de Silva
Peter de Vries
Jillian Deacon
David Dean
Alexa Debard
Marie-Pierre Debray
Nathalie DeCastro
William Dechert
Lauren Deconninck
Romain Decours
Eve Defous
Isabelle Delacroix
Eric Delaveuve
Karen Delavigne
Andrea Dell’Amore
Pierre Delobel
Corine Delsing
Elisa Demonchy
Emmanuelle Denis
Dominique Deplanque
Pieter Depuydt
Diane Descamps
Mathilde Desvallées
Santi Dewayanti
Pathik Dhanger
Alpha Diallo
Sylvain Diamantis
André Dias
Juan Jose Diaz
Priscila Diaz
Kévin Didier
Jean-Luc Diehl
Wim Dieperink
Jérôme Dimet
Vincent Dinot
Fara Diop
Alphonsine Diouf
Yael Dishon
Félix Djossou
Annemarie B Docherty
Helen Doherty
Arjen M Dondorp
Christl A Donnelly
Maria Donnelly
Chloe Donohue
Sean Donohue
Yoann Donohue
Peter Doran
Céline Dorival
Eric D’Ortenzio
James Joshua Douglas
Nathalie Dournon
Triona Downer
Joanne Downey
Mark Downing
Tom Drake
Aoife Driscoll
Claudio Duarte Fonseca
Vincent Dubee
François Dubos
Alexandre Ducancelle
Susanne Dudman
Paul Dunand
Jake Dunning
Mathilde Duplaix
Emanuele Durante-Mangoni
Lucian Durham
Bertrand Dussol
Juliette Duthoit
Xavier Duval
Anne Margarita Dyrhol-Riise
Marco Echeverria-Villalobos
Siobhan Egan
Carla Eira
Mohammed El Sanharawi
Subbarao Elapavaluru
Brigitte Elharrar
Jacobien Ellerbroek
Philippine Eloy
Tarek Elshazly
Isabelle Enderle
Tomoyuki Endo
Ilka Engelmann
Vincent Enouf
Olivier Epaulard
Martina Escher
Mariano Esperatti
Hélène Esperou
Catarina Espírito Santo
Marina Esposito-Farese
João Estevão
Manuel Etienne
Nadia Ettalhaoui
Anna Greti Everding
Mirjam Evers
Isabelle Fabre
Marc Fabre
Amna Faheem
Arabella Fahy
Cameron J Fairfield
Zul Fakar
Komal Fareed
Pedro Faria
Ahmed Farooq
Arie Zainul Fatoni
Karine Faure
Raphaël Favory
Mohamed Fayed
Niamh Feely
Laura Feeney
Jorge Fernandes
Marília Andreia Fernandes
Susana Fernandes
François-Xavier Ferrand
Eglantine Ferrand Devouge
Joana Ferrão
Mário Ferraz
Benigno Ferreira
Bernardo Ferreira
Isabel Ferreira
Sílvia Ferreira
Ricard Ferrer-Roca
Nicolas Ferriere
Céline Ficko
Juan Fiorda
Thomas Flament
Clara Flateau
Tom Fletcher
Letizia Lucia Florio
Deirdre Flynn
Claire Foley
Jean Foley
Victor Fomin
Tatiana Fonseca
Patricia Fontela
Simon Forsyth
Denise Foster
Giuseppe Foti
Erwan Fourn
Marianne Fraher
Diego Franch-Llasat
Christophe Fraser
John F Fraser
Marcela Vieira Freire
Ana Freitas Ribeiro
Craig French
Caren Friedrich
Stéphanie Fry
Nora Fuentes
Masahiro Fukuda
Argin G
Valérie Gaborieau
Rostane Gaci
Massimo Gagliardi
Jean-Charles Gagnard
Amandine Gagneux-Brunon
Sérgio Gaião
Linda Gail Skeie
Phil Gallagher
Carrol Gamble
Arthur Garan
Rebekha Garcia
Noelia García Barrio
Navya Garimella
Denis Garot
Valérie Garrait
Basanta Gauli
Nathalie Gault
Aisling Gavin
Anatoliy Gavrylov
Alexandre Gaymard
Johannes Gebauer
Eva Geraud
Louis Gerbaud Morlaes
Nuno Germano
Jade Ghosn
Marco Giani
Jess Gibson
Tristan Gigante
Morgane Gilg
Elaine Gilroy
Guillermo Giordano
Michelle Girvan
Valérie Gissot
Daniel Glikman
Petr Glybochko
Eric Gnall
Geraldine Goco
François Goehringer
Siri Goepel
Jean-Christophe Goffard
Jonathan Golob
Joan Gómez-Junyent
Marie Gominet
Alicia Gonzalez
Patricia Gordon
Isabelle Gorenne
Laure Goubert
Cécile Goujard
Tiphaine Goulenok
Margarite Grable
Jeronimo Graf
Edward Wilson Grandin
Pascal Granier
Giacomo Grasselli
Christopher A Green
Courtney Greene
William Greenhalf
Segolène Greffe
Domenico Luca Grieco
Matthew Griffee
Fiona Griffiths
Albert Groenendijk
Anja Grosse Lordemann
Heidi Gruner
Yusing Gu
Jérémie Guedj
Martin Guego
Dewi Guellec
Anne-Marie Guerguerian
Daniela Guerreiro
Romain Guery
Anne Guillaumot
Laurent Guilleminault
Maisa Guimarães de Castro
Thomas Guimard
Marieke Haalboom
Daniel Haber
Hannah Habraken
Ali Hachemi
Nadir Hadri
Fakhir Haidri
Sheeba Hakak
Adam Hall
Matthew Hall
Sophie Halpin
Jawad Hameed
Ansley Hamer
Rebecca Hamidfar
Terese Hammond
Rashan Haniffa
Hayley Hardwick
Ewen M Harrison
Janet Harrison
Samuel Bernard Ekow Harrison
Mohd Shahnaz Hasan
Junaid Hashmi
Muhammad Hayat
Ailbhe Hayes
Leanne Hays
Jan Heerman
Lars Heggelund
Ross Hendry
Martina Hennessy
Maxime Hentzien
Andrew Hershey
Liv Hesstvedt
Astarini Hidayah
Dawn Higgins
Eibhilin Higgins
Rupert Higgins
Rita Hinchion
Samuel Hinton
Hikombo Hitoto
Antonia Ho
Alexandre Hoctin
Isabelle Hoffmann
Oscar Hoiting
Rebecca Holt
Jan Cato Holter
Peter Horby
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Koji Hoshino
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Ikram Houas
Catherine L Hough
Jimmy Ming-Yang Hsu
Jean-Sébastien Hulot
Stella Huo
Abby Hurd
Iqbal Hussain
Samreen Ijaz
Arfan Ikram
Hajnal-Gabriela Illes
Patrick Imbert
Mohammad Imran
Rana Imran Sikander
Aftab Imtiaz
Hugo Inácio
Carmen Infante Dominguez
Mariachiara Ippolito
Sarah Isgett
Tiago Isidoro
Margaux Isnard
Daniel Ivulich
Danielle Jaafar
Salma Jaafoura
Julien Jabot
Clare Jackson
Nina Jamieson
Pierre Jaquet
Coline Jaud-Fischer
Stéphane Jaureguiberry
Florence Jego
Synne Jenum
Ruth N. Jorge García
Cédric Joseph
Mark Joseph
Swosti Joshi
Mercé Jourdain
Philippe Jouvet
Anna Jung
Dafsah Juzar
Ouifiya Kafif
Florentia Kaguelidou
Sabina Kali
Smaragdi Kalomoiri
Darshana Hewa Kandamby
Chris Kandel
Darakhshan Kanwal
Anant Kataria
Kevin Katz
Christy Kay
Hannah Keane
Seán Keating
Andrea Kelly
Aoife Kelly
Claire Kelly
Niamh Kelly
Sadie Kelly
Yvelynne Kelly
Maeve Kelsey
Kalynn Kennon
Maeve Kernan
Younes Kerroumi
Sharma Keshav
Imrana Khalid
Osama Khalid
Antoine Khalil
Coralie Khan
Irfan Khan
Quratul Ain Khan
Sushil Khanal
Abid Khatak
Amin Khawaja
Michelle E Kho
Saye Khoo
Nasir Khoso
Yuri Kida
Peter Kiiza
Beathe Kiland Granerud
Anders Benjamin Kildal
Antoine Kimmoun
Detlef Kindgen-Milles
Nobuya Kitamura
Paul Klenerman
Rob Klont
Gry Kloumann Bekken
Stephen R Knight
Robin Kobbe
Chamira Kodippily
Malte Kohns Vasconcelos
Sabin Koirala
Caroline Kosgei
Arsène Kpangon
Karolina Krawczyk
Oksana Kruglova
Deepali Kumar
Mukesh Kumar
Bharath Kumar Tirupakuzhi Vijayaraghavan
Pavan Kumar Vecham
Dinesh Kuriakose
Ethan Kurtzman
Demetrios Kutsogiannis
Galyna Kutsyna
Konstantinos Kyriakoulis
Marie Lachatre
Marie Lacoste
John G Laffey
Marie Lagrange
Fabrice Laine
Olivier Lairez
Sanjay Lakhey
Antonio Lalueza
Marc Lambert
François Lamontagne
Marie Langelot-Richard
Vincent Langlois
Eka Yudha Lantang
Marina Lanza
Cédric Laouénan
Samira Laribi
Delphine Lariviere
Stéphane Lasry
Naveed Latif
Odile Launay
Didier Laureillard
Yoan Lavie-Badie
Andrew Law
Cassie Lawrence
Teresa Lawrence
Minh Le
Clément Le Bihan
Cyril Le Bris
Georges Le Falher
Lucie Le Fevre
Quentin Le Hingrat
Marion Le Maréchal
Soizic Le Mestre
Gwenaël Le Moal
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Hervé Le Nagard
Paul Le Turnier
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Marta Leal Santos
James Lee
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Su Hwan Lee
Todd C Lee
Gary Leeming
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Laurent Lefebvre
Benjamin Lefèvre
Sylvie LeGac
Jean-Daniel Lelievre
François Lellouche
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Véronique Lemee
Anthony Lemeur
Gretchen Lemmink
Jenny Lennon
Rafael León
Marc Leone
Michela Leone
François-Xavier Lescure
Olivier Lesens
Mathieu Lesouhaitier
Amy Lester-Grant
Bruno Levy
Yves Levy
Claire Levy-Marchal
Katarzyna Lewandowska
Erwan L’Her
Gianluigi Li Bassi
Ali Liaquat
Geoffrey Liegeon
Wei Shen Lim
Chantre Lima
Bruno Lina
Andreas Lind
Guillaume Lingas
Sylvie Lion-Daolio
Keibun Liu
Marine Livrozet
Patricia Lizotte
Antonio Loforte
Navy Lolong
Diogo Lopes
Anthony L Loschner
Paul Loubet
Bouchra Loufti
Guillame Louis
Silvia Lourenco
Lara Lovelace-Macon
Marije Lowik
Jean Christophe Lucet
Carlos Lumbreras Bermejo
Carlos M Luna
Liem Luong
Nestor Luque
Dominique Luton
Nilar Lwin
Ruth Lyons
Olavi Maasikas
Oryane Mabiala
Moïse Machado
Sara Machado
Gabriel Macheda
Hashmi Madiha
Guillermo Maestro de la Calle
Rafael Mahieu
Sophie Mahy
Ana Raquel Maia
Lars S Maier
Mylène Maillet
Thomas Maitre
Maximilian Malfertheiner
Nadia Malik
Paddy Mallon
Fernando Maltez
Denis Malvy
Victoria Manda
Laurent Mandelbrot
Julie Mankikian
Edmund Manning
Aldric Manuel
Ceila Maria Sant
Ana Malaque
Daniel Marino
Flávio Marino
Samuel Markowicz
Ana Marques
Catherine Marquis
Brian Marsh
Laura Marsh
Megan Marshal
Celina Turchi Martelli
Emily Martin
Guillaume Martin-Blondel
Martin Martinot
Ana Martins
João Martins
Nuno Martins
Caroline Martins Rego
Gennaro Martucci
Olga Martynenko
Eva Miranda Marwali
David Maslove
Sabina Mason
Sobia Masood
Basri Mat Nor
Moshe Matan
Meghena Mathew
Daniel Mathieu
Mathieu Mattei
Romans Matulevics
Laurence Maulin
Michael Maxwell
Javier Maynar
Thierry Mazzoni
Natalie Mc Evoy
Lisa Mc Sweeney
Colin McArthur
Aine McCarthy
Anne McCarthy
Colin McCloskey
Rachael McConnochie
Sherry McDermott
Sarah E McDonald
Aine McElroy
Samuel McElwee
Victoria McEneany
Allison McGeer
Chris McKay
Johnny McKeown
Kenneth A McLean
Paul McNally
Bairbre McNicholas
Elaine McPartlan
Edel Meaney
Cécile Mear-Passard
Maggie Mechlin
Minahel Atif
Maqsood Meher
Ferruccio Mele
Luis Melo
Kashif Memon
Joao Joao Mendes
Ogechukwu Menkiti
Kusum Menon
France Mentré
Alexander J Mentzer
Emmanuelle Mercier
Noémie Mercier
Antoine Merckx
Mayka Mergeay-Fabre
Blake Mergler
António Mesquita
Osama Metwally
Agnès Meybeck
Dan Meyer
Alison M Meynert
Vanina Meysonnier
Amina Meziane
Mehdi Mezidi
Céline Michelanglei
Isabelle Michelet
Vladislav Mihnovit
Asma Moin
David Molina
Elena Molinos
Brenda Molloy
Mary Mone
Agostinho Monteiro
Claudia Montes
Giorgia Montrucchio
Sarah Moore
Shona C Moore
Lina Morales Cely
Lucia Moro
Catherine Motherway
Ana Motos
Hugo Mouquet
Clara Mouton Perrot
Julien Moyet
Aisha Kalsoom Mufti
Jimmy Mullaert
Fredrik Müller
Karl Erik Müller
Daniel Munblit
Syed Muneeb
Nadeem Munir
Aisling Murphy
Lorna Murphy
Marlène Murris
Himed Musaab
Himasha Muvindi
Dimitra Melia Myrodia
Farah Nadia Mohd-Hanafiah
Dave Nagpal
Alex Nagrebetsky
Nageswaran Narayanan
Rashid Nasim Khan
Alasdair Nazerali-Maitland
Nadège Neant
Nikita Nekliudov
Raul Neto
Emily Neumann
Pauline Yeung Ng
Anthony Nghi
Duc Nguyen
Orna Ni Choileain
Niamh Ni Leathlobhair
Prompak Nitayavardhana
Stephanie Nonas
Marion Noret
Lisa Norman
Alessandra Notari
Mahdad Noursadeghi
Adam Nowinski
Saad Nseir
Jose I Nunez
Nurnaningsih Nurnaningsih
Elsa Nyamankolly
Fionnuala O Brien
Annmarie O Callaghan
Annmarie O’Callaghan
Giovanna Occhipinti
Derbrenn OConnor
Max O’Donnell
Tawnya Ogston
Takayuki Ogura
Sophie O’Halloran
Katie O’Hearn
João Oliveira
Larissa Oliveira
David S. Y Ong
Wilna Oosthuyzen
Anne Opavsky
Peter Openshaw
Saijad Orakzai
Claudia Milena Orozco-Chamorro
Jamel Ortoleva
Javier Osatnik
Linda O’Shea
Miriam O’Sullivan
Nadia Ouamara
Rachida Ouissa
Eric Oziol
Maïder Pagadoy
Justine Pages
Amanda Palacios
Mario Palacios
Massimo Palmarini
Giovanna Panarello
Hem Paneru
Mauro Panigada
Nathalie Pansu
Aurélie Papadopoulos
Rachael Parke
Melissa Parker
Briseida Parra
Taha Pasha
Jérémie Pasquier
Bruno Pastene
Fabian Patauner
Luís Patrão
Patricia Patricio
Juliette Patrier
Lisa Patterson
Rajyabardhan Pattnaik
Christelle Paul
Mical Paul
Jorge Paulos
William A Paxton
Jean-François Payen
Florent Peelman
Nathan Peiffer-Smadja
Vincent Peigne
Mare Pejkovska
Paolo Pelosi
Ithan D Peltan
Rui Pereira
Daniel Perez
Luis Periel
Thomas Perpoint
Antonio Pesenti
Vincent Pestre
Lenka Petrou
Michele Petrovic
Ventzislava Petrov-Sanchez
Frank Olav Pettersen
Gilles Peytavin
Scott Pharand
Walter Picard
Olivier Picone
Carola Pierobon
Djura Piersma
Carlos Pimentel
Raquel Pinto
Catarina Pires
Isabelle Pironneau
Lionel Piroth
Riinu Pius
Laurent Plantier
Julien Poissy
Ryadh Pokeerbux
Sergio Poli
Georgios Pollakis
Diane Ponscarme
Andra-Maris Post
Douwe F Postma
Pedro Povoa
Diana Póvoas
Jeff Powis
Sofia Prapa
Sébastien Preau
Christian Prebensen
Jean-Charles Preiser
Anton Prinssen
Mark G Pritchard
Gamage Dona Dilanthi Priyadarshani
Lucia Proença
Sravya Pudota
Oriane Puéchal
Bambang Pujo Semedi
Mathew Pulicken
Gregory Purcell
Luisa Quesada
Vilmaris Quinones-Cardona
Víctor Quirós González
Else Quist-Paulsen
Mohammed Quraishi
Christian Rabaud
Ebenezer Rabindrarajan
Aldo Rafael
Marie Rafiq
Arsalan Rahutullah
Fernando Rainieri
Pratheema Ramachandran
Nagarajan Ramakrishnan
José Ramalho
Blandine Rammaert
Grazielle Viana Ramos
Asim Rana
Rajavardhan Rangappa
Ritika Ranjan
Christophe Rapp
Aasiyah Rashan
Thalha Rashan
Ghulam Rasheed
Menaldi Rasmin
Indrek Rätsep
Cornelius Rau
Ali Raza
Andre Real
Stanislas Rebaudet
Sarah Redl
Brenda Reeve
Attaur Rehman
Liadain Reid
Dag Henrik Reikvam
Renato Reis
Jonathan Remppis
Martine Remy
Hongru Ren
Hanna Renk
Anne-Sophie Resseguier
Matthieu Revest
Oleksa Rewa
Tiago Reyes
Maria Ines Ribeiro
David Richardson
Denise Richardson
Laurent Richier
Jordi Riera
Ana L Rios
Asgar Rishu
Patrick Rispal
Karine Risso
Nicholas Rizer
Chiara Robba
André Roberto
Stephanie Roberts
David L Robertson
Olivier Robineau
Ferran Roche-Campo
Paola Rodari
Simão Rodeia
Julia Rodriguez Abreu
Bernhard Roessler
Pierre-Marie Roger
Amanda Rojek
Juliette Romaru
Roberto Roncon-Albuquerque
Mélanie Roriz
Manuel Rosa-Calatrava
Michael Rose
Dorothea Rosenberger
Andrea Rossanese
Matteo Rossetti
Bénédicte Rossignol
Patrick Rossignol
Stella Rousset
Carine Roy
Benoît Roze
Desy Rusmawatiningtyas
Clark D Russell
Maeve Ryan
Maria Ryan
Steffi Ryckaert
Aleksander Rygh Holten
Isabela Saba
Sairah Sadaf
Musharaf Sadat
Valla Sahraei
Nadia Saidani
Maximilien Saint-Gilles
Pranya Sakiyalak
Nawal Salahuddin
Leonardo Salazar
Jodat Saleem
Gabriele Sales
Stéphane Sallaberry
Charlotte Salmon Gandonniere
Hélène Salvator
Olivier Sanchez
Angel Sanchez-Miralles
Vanessa Sancho-Shimizu
Gyan Sandhu
Zulfiqar Sandhu
Pierre-François Sandrine
Oana Sandulescu
Marlene Santos
Shirley Sarfo-Mensah
Bruno Sarmento Banheiro
Benjamine Sarton
Sree Satyapriya
Rumaisah Satyawati
Egle Saviciute
Justin Schaffer
Tjard Schermer
Arnaud Scherpereel
Marion Schneider
Stephan Schroll
Michael Schwameis
Janet T Scott
James Scott-Brown
Nicholas Sedillot
Tamara Seitz
Jaganathan Selvanayagam
Caroline Semaille
Malcolm G Semple
Eric Senneville
Filipa Sequeira
Tânia Sequeira
Ary Serpa Neto
Pablo Serrano Balazote
Ellen Shadowitz
Mohammad Shamsah
Shaikh Sharjeel
Pratima Sharma
Catherine A Shaw
Victoria Shaw
Ashraf Sheharyar
Rajesh Mohan Shetty
Haixia Shi
Mohiuddin Shiekh
Keiki Shimizu
Sally Shrapnel
Shubha Kalyan Shrestha
Pramesh Sundar Shrestha
Hoi Ping Shum
Nassima Si Mohammed
Jeanne Sibiude
Atif Siddiqui
Louise Sigfrid
Piret Sillaots
Catarina Silva
Maria Joao Silva
Rogério Silva
Wai Ching Sin
Budha Charan Singh
Punam Singh
Pompini Agustina Sitompul
Vegard Skogen
Sue Smith
Benjamin Smood
Coilin Smyth
Michelle Smyth
Morgane Snacken
Dominic So
Joshua Solomon
Tom Solomon
Emily Somers
Agnès Sommet
Myung Jin Song
Rima Song
Tae Song
Jack Song Chia
Albert Sotto
Edouard Soum
Ana Chora Sousa
Marta Sousa
Maria Sousa Uva
Alexandra Sperry
Elisabetta Spinuzza
B. P. Sanka Ruwan Sri Darshana
Shiranee Sriskandan
Sarah Stabler
Thomas Staudinger
Stephanie-Susanne Stecher
Ymkje Stienstra
Birgitte Stiksrud
Eva Stolz
Amy Stone
Adrian Streinu-Cercel
Anca Streinu-Cercel
Ami Stuart
David Stuart
Gabriel Suen
Jacky Y Suen
Asfia Sultana
Charlotte Summers
Dubravka Supic
Magdalena Surovcová
Andrey Svistunov
Konstantinos Syrigos
Jaques Sztajnbok
Konstanty Szuldrzynski
Shirin Tabrizi
Lysa Tagherset
Sara Taleb
Jelmer Talsma
Maria Lawrensia Tampubolon
Hiroyuki Tanaka
Huda Taqdees
Arshad Taqi
Coralie Tardivon
Pierre Tattevin
M. Azhari Taufik
Hassan Tawfik
Richard S Tedder
João Teixeira
Sofia Tejada
Marie-Capucine Tellier
François Téoulé
Pleun Terpstra
Olivier Terrier
Nicolas Terzi
Hubert Tessier-Grenier
Adrian Tey
Anand Thakur
Vincent Thibault
Simon-Djamel Thiberville
Benoît Thill
Shaun Thompson
Emma C Thomson
Ryan S Thwaites
Paul Tierney
Vadim Tieroshyn
Peter S Timashev
Jean-François Timsit
Noémie Tissot
Maria Toki
Kristian Tonby
Marta Torre
Antoni Torres
Margarida Torres
Hernando Torres-Zevallos
Michael Towers
Tony Trapani
Théo Treoux
Cécile Tromeur
Ioannis Trontzas
Tiffany Trouillon
Jeanne Truong
Christelle Tual
Sarah Tubiana
Helen Tuite
Jean-Marie Turmel
Lance C. W Turtle
Pawel Twardowski
Makoto Uchiyama
P. G. Ishara Udayanga
Andrew Udy
Roman Ullrich
Alberto Uribe
Asad Usman
Timothy M Uyeki
Cristinava Vajdovics
Luís Val-Flores
Amélie Valran
Stijn Van de Velde
Marcel van den Berge
Job van der Palen
Paul van der Valk
Nicky Van Der Vekens
Peter Van der Voort
Sylvie Van Der Werf
Laura van Gulik
Jarne Van Hattem
Carolien van Netten
Ilonka van Veen
Noémie Vanel
Henk Vanoverschelde
Pooja Varghese
Charline Vauchy
Aurélie Veislinger
Sebastian Vencken
Sara Ventura
Annelies Verbon
James Vickers
José Ernesto Vidal
César Vieira
Deepak Vijayan
Joy Ann Villanueva
Judit Villar
Pierre-Marc Villeneuve
Andrea Villoldo
Benoit Visseaux
Hannah Visser
Chiara Vitiello
Harald Vonkeman
Fanny Vuotto
Wan Fadzlina Wan Muhd Shukeri
Chih-Hsien Wang
Steve Webb
Jia Wei
Katharina Weil
Sanne Wesselius
T. Eoin West
Murray Wham
Bryan Whelan
Nicole White
Paul Henri Wicky
Aurélie Wiedemann
Surya Otto Wijaya
Keith Wille
Suzette Willems
Virginie Williams
Evert-Jan Wils
Ng Wing Yiu
Calvin Wong
Ioannis Xynogalas
Masaki Yamazaki
Yazdan Yazdanpanah
Cécile Yelnik
Stephanie Yerkovich
Toshiki Yokoyama
Hodane Yonis
Obada Yousif
Saptadi Yuliarto
Akram Zaaqoq
Marion Zabbe
Maram Zahran
Maria Zambon
Alberto Zanella
Hiba Zayyad
Alexander Zoufaly
David Zucman
Éditeur: BioMed Central
Identifiants: 99148021609311
Unité académique: Virulence Bacterienne et Infections Chroniques - VBIC; Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article