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Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions
Journal article   Peer reviewed

Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions

A. Lassaux, Marc Sitbon and Jean-Luc Battini
Journal of Virology, Vol.79(10), pp.6560--4
2005
PMCID: PMC1091700

Abstract

Amino Acid Sequence Animals Capsid Proteins/chemistry/*genetics Cell Line DNA-(Apurinic or Apyrimidinic Site) Lyase/*genetics Genes Molecular Molecular Sequence Data Proteins/*genetics Restriction Mapping Retroviridae Infections/*virology Sequence Alignment Transfection Tumor Virus Infections/*virology Murine/*genetics Mice Models Viral/genetics Humans Leukemia Virus
We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.
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