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Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa.
Journal article   Peer reviewed

Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa.

Didier Hocquet, Arno Muller, Karine Blanc, Patrick Plésiat, Daniel Talon, Dominique Louis Monnet and Xavier Bertrand
Antimicrobial Agents and Chemotherapy, Vol.52(3), pp.1173-5
03/2008
DOI: https://doi.org/10.1128/AAC.01212-07
PMCID: PMC2258510
PMID: 18180356

Abstract

Aminoglycosides Anti-Bacterial Agents Bacterial Proteins Cephalosporins Culture Media Drug Resistance, Multiple Fluoroquinolones France Hospitals, University Humans Incidence Membrane Transport Proteins Microbial Sensitivity Tests Mutation Pseudomonas Infections Pseudomonas aeruginosa Bacterial Outer Membrane Proteins
In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.
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