Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study

Florian Reizine; Nicolas Massart; Alexandre Mansour; Yannick Fedun; Anaïs Machut; Charles-Hervé Vacheron; Anne Savey; Arnaud Friggeri; Alain Lepape; Serge Alfandari; Alexandra Allaire; Antonio Alvarez; Ammenouche Nacim; Laurent Argaus; Gérard Audibert; Caroline Aurel; Odile Bajolet; Frédéric Barbut; Genevieve Barjon; Patricia Baune; Sébastien Beague; Bassam Beilouny; Nicolas Bele; Nicolas Belin; Cécile Bernerd; Yasmina Berrouane; Aziz Berrouba; Julie Bertrand; Claire Bianchi; Sandrine Biangoma; Fabienne Birot Jaulin; Severine Bonjean; Stéphanie Bordes-Couecou; Abdenour Bouhara; Philippe Bouillard; Céline Bourigault; Sylvie Bourzeix; Sébastien Boutreux; Hanene Bouzidi; Julie Brochart; Stéphanie Bulyez; Marie Callanquin; Nathalie Canu; Matthieu Capron; Daniel Carbognani; Vincent Castelain; Vincent Catanese; Isabelle Cattaneo; Vanessa Chartier; Guillaume Chassaing; Robert Chausset; Mélanie Chauvet; Fabrice Chopin; Catherine Chubilleau; Céline Clayer; Agnès Cohen; Sylvie Comparot; Philippe Corne; Marie-Elisabeth Cornesse; Gaelle Corno; Esther Cortes; Patricia Courouble; Christian Crombe; Véronique Curnier; Monzer Dabbachi; Cédric Dananché; Abla Daroukh; Damien Dassant; Martine Daumas; Aurélien Daurat; Dominique Deffarges; Fanny Delanghe; Olivier Delastre; Joel Delhomme; Jean Paul Délias; Martine Delorme; Fabienne Derramond; Frédérique Diaw; Isabelle Dijols; Kamel Djedaini; Loic Dopeux; Sophie Duhoo; Thierry Dulac; Clarisse Dupin; Laurène Dupont; Michel Durand; Isabelle Durand Joly; Jean-Yves Dusseau; Pierre Yves Egreteau; Carole Eldin; Florence Espinasse; Eric Farfour; Abdelhamid Fatah; Luis Ferreira; Pierre Fillatre; Toufic Finge; Véronique Fleurial; Arnaud Florentin; Agnès Fribourg; Severine Gallais-Hoff; Claude Galland; Richard Galliot; Sylvain Garnier; Gaelle Gasan; Julien Gaubert-Duclos; Valérie Gauzere; Thomas Geffriaud; Isabelle Geneau; Hughes Georges; Solweig Gerbier Colomban; Christophe Giacardi; Sebastien Gibot; Audrey Glanard; Marion Gleize; Marieline Goret; Michele Gourgues; Delphine Grau; Béatrice Grisi; Clotilde Groleau; Liliane Grolier-Bois; Catherine Guignabert; Fethi Hadj-Slimane; Emmanuelle Hammad; Catherine Haond; Marie Hélène Hausermann; Francoise Hayo; Christophe Henry; Alexandre Herbland; Julien Huntzinger; Hervé Hyvernat; Alexandre Jean; Boris Jolibois; Sylvie Joron; Gauthier Julien; Jean Kempf; Lyes Knani; Béatrice La Combe; Marie Labruyere; Sandrine Lacroix; Bruno Lafon; Katia Lamant; Peggy Larroudé; Anne Launoy; Bernadette Laurent; Thierry Lavigne; Christine Lawrence; Quoc Vien Le; Muriel Le Coq; Anne-Sophie Le Floch; Fanny Le Fall; Brigitte Le Tallec; Lucie Lecoutre; Stanislas Ledochowski; Rusel Leon; Claire Lepouse; Thomas Lescot; Mélanie Levrard; Marie Laure Lier; Anne Lignereux; Benjamin Louart; Claire Maheu; Aurélie Maindron; Francois Mallard; Marie Reine Mallaret; Bernard Mankikian; Christiane Manzon; Philippe Mardrus; Jacques Mariot; Audry Martin; Emmanuelle Martin; Maelle Martin; Pascale Martres; Virginie Maxime; Olivier Meunier; Ella-Pauline Meyer; Ferhat Meziani; Sébastien Moschietto; Céline Muller; Elodie Munier-Marion; Caroline Neulier; François Nicolas; Jacques-Yves Nizou; Christine Palitta; Michel Pascal; Olivier Passouant; René-Gilles Patrigeon; Frédérique Pavillard; Sabine Peghaire; Christophe Perdrix; Jean-Sebastien Petit; Judith Pibre; Walter Picard; Sylvie Picault; Santiago Picos Gil; Jérôme Pillot; Patrick Pina; Rémi Plattier; Laurent Poiron; Christian Pommier; Gaël Pradel; Cristian Prelipcean; Paul-Simon Pugliesi; Vincent Quenee; Olga Raposo; Eve Remy; Sabine Reynaud Deforges; Jean-Christophe Richard; Sylvie Ricome; Thomas Rimmele; Adrien Robine; Anne-Claude Roche; Laetitia Rohr; Gwenaël Rolland-Jacob; Adrien Roques; Catherine Rougier; Jérôme Roustan; Mélanie Saint-Leger; Faouzi Saliba; Dominique Sechaud; Amine Si-Ali; Catherine Simac; Georges Simon; Michel Sirodot; Vincent Stoeckel; Philippe Tagawa; Marine Tasle; Fabrice Thiollière; Benoit Thiphagne; Aurélie Thomas-Hervieu; François Tinturier; Alexandre Tonnelier; Alexandre Toro; David Tranvan; Dominique Trivier; Gilles Troché; Rémi Trusson; Lionel Ursulet; Marie Laure Valdeyron; Catherine Vallet; Vanessa van Rossem; Laurence Vasse; Myriam Venelle; Christine Venot; Antoine Vieillard-Baron; Jean-François Vincent; Michel Vitris; Hussein Yassine; Lassane Zanre; Cecile Zylberfajn

doi:10.1186/s13054-024-05104-w

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Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study

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Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study

Florian Reizine, Nicolas Massart, Alexandre Mansour, Yannick Fedun, Anaïs Machut, Charles-Hervé Vacheron, Anne Savey, Arnaud Friggeri, Alain Lepape, Serge Alfandari, …

Critical Care, Vol.28(1)

27/09/2024

DOI: https://doi.org/10.1186/s13054-024-05104-w

Abstract

Candidaemia

COVID-19

ICU

Healthcare associated infection

BackgroundWhile SARS-CoV2 infection has been shown to be a significant risk-factor for several secondary bacterial, viral and Aspergillus infections, its impact on intensive care unit (ICU)-acquired candidemia (ICAC) remains poorly explored.MethodUsing the REA-REZO network (French surveillance network of ICU-acquired infections), we included all adult patients hospitalized for a medical reason of admission in participating ICUs for at least 48 h from January 2020 to January 2023. To account for confounders, a non-parsimonious propensity score matching was performed. Rates of ICAC according to SARS-CoV2 status were compared in matched patients. Factors associated with ICAC in COVID-19 patients were also assessed using a Fine-Gray model.ResultsA total of 55,268 patients hospitalized at least 48 h for a medical reason in 101 ICUs were included along the study period. Of those, 13,472 were tested positive for a SARS-CoV2 infection while 284 patients developed an ICAC. ICAC rate was higher in COVID-19 patients in both the overall population and the matched patients’ cohort (0.8% (107/13,472) versus 0.4% (173/41,796); p < 0.001 and 0.8% (93/12,241) versus 0.5% (57/12,241); p = 0.004, respectively). ICAC incidence rate was also higher in those patients (incidence rate 0.51 per 1000 patients-days in COVID-19 patients versus 0.32 per 1000 patients-days; incidence rate ratio: 1.58 [95% CI:1.08–2.35]; p = 0.018). Finally, patients with ICAC had a higher ICU mortality rate (49.6% versus 20.2%; p < 0.001).ConclusionIn this large multicenter cohort of ICU patients, although remaining low, the rate of ICAC was higher among COVID-19 patients.

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Title: Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study
Creators - without role: Florian Reizine - Centre hospitalier Bretagne Atlantique
Nicolas Massart - Centre Hospitalier de Saint-Brieuc
Alexandre Mansour - Centre Hospitalier Universitaire de Rennes
Yannick Fedun - Centre hospitalier Bretagne Atlantique
Anaïs Machut
Charles-Hervé Vacheron
Anne Savey - Centre International de Recherche en Infectiologie
Arnaud Friggeri - Hôpital Lyon Sud
Alain Lepape - Hospices Civils de Lyon
Serge Alfandari
Alexandra Allaire
Antonio Alvarez
Ammenouche Nacim
Laurent Argaus
Gérard Audibert
Caroline Aurel
Odile Bajolet
Frédéric Barbut
Genevieve Barjon
Patricia Baune
Sébastien Beague
Bassam Beilouny
Nicolas Bele
Nicolas Belin
Cécile Bernerd
Yasmina Berrouane
Aziz Berrouba
Julie Bertrand
Claire Bianchi
Sandrine Biangoma
Fabienne Birot Jaulin
Severine Bonjean
Stéphanie Bordes-Couecou
Abdenour Bouhara
Philippe Bouillard
Céline Bourigault
Sylvie Bourzeix
Sébastien Boutreux
Hanene Bouzidi
Julie Brochart
Stéphanie Bulyez
Marie Callanquin
Nathalie Canu
Matthieu Capron
Daniel Carbognani
Vincent Castelain
Vincent Catanese
Isabelle Cattaneo
Vanessa Chartier
Guillaume Chassaing
Robert Chausset
Mélanie Chauvet
Fabrice Chopin
Catherine Chubilleau
Céline Clayer
Agnès Cohen
Sylvie Comparot
Philippe Corne
Marie-Elisabeth Cornesse
Gaelle Corno
Esther Cortes
Patricia Courouble
Christian Crombe
Véronique Curnier
Monzer Dabbachi
Cédric Dananché
Abla Daroukh
Damien Dassant
Martine Daumas
Aurélien Daurat
Dominique Deffarges
Fanny Delanghe
Olivier Delastre
Joel Delhomme
Jean Paul Délias
Martine Delorme
Fabienne Derramond
Frédérique Diaw
Isabelle Dijols
Kamel Djedaini
Loic Dopeux
Sophie Duhoo
Thierry Dulac
Clarisse Dupin
Laurène Dupont
Michel Durand
Isabelle Durand Joly
Jean-Yves Dusseau
Pierre Yves Egreteau
Carole Eldin
Florence Espinasse
Eric Farfour
Abdelhamid Fatah
Yannick Fedun - Centre hospitalier Bretagne Atlantique
Luis Ferreira
Pierre Fillatre
Toufic Finge
Véronique Fleurial
Arnaud Florentin
Agnès Fribourg
Severine Gallais-Hoff
Claude Galland
Richard Galliot
Sylvain Garnier
Gaelle Gasan
Julien Gaubert-Duclos
Valérie Gauzere
Thomas Geffriaud
Isabelle Geneau
Hughes Georges
Solweig Gerbier Colomban
Christophe Giacardi
Sebastien Gibot
Audrey Glanard
Marion Gleize
Marieline Goret
Michele Gourgues
Delphine Grau - Université de Montpellier, Hydrosciences Montpellier - HSM
Béatrice Grisi
Clotilde Groleau
Liliane Grolier-Bois
Catherine Guignabert
Fethi Hadj-Slimane
Emmanuelle Hammad
Catherine Haond
Marie Hélène Hausermann
Francoise Hayo
Christophe Henry
Alexandre Herbland
Julien Huntzinger
Hervé Hyvernat
Alexandre Jean
Boris Jolibois
Sylvie Joron
Gauthier Julien
Jean Kempf
Lyes Knani
Béatrice La Combe
Marie Labruyere
Sandrine Lacroix
Bruno Lafon
Katia Lamant
Peggy Larroudé
Anne Launoy
Bernadette Laurent
Thierry Lavigne
Christine Lawrence
Quoc Vien Le
Muriel Le Coq
Anne-Sophie Le Floch
Fanny Le Fall
Brigitte Le Tallec
Lucie Lecoutre
Stanislas Ledochowski
Rusel Leon
Claire Lepouse
Thomas Lescot
Mélanie Levrard
Marie Laure Lier
Anne Lignereux
Benjamin Louart
Claire Maheu
Aurélie Maindron
Francois Mallard
Marie Reine Mallaret
Bernard Mankikian
Christiane Manzon
Philippe Mardrus
Jacques Mariot
Audry Martin
Emmanuelle Martin
Maelle Martin
Pascale Martres
Virginie Maxime
Olivier Meunier
Ella-Pauline Meyer
Ferhat Meziani
Sébastien Moschietto
Céline Muller
Elodie Munier-Marion
Caroline Neulier
François Nicolas
Jacques-Yves Nizou
Christine Palitta
Michel Pascal
Olivier Passouant
René-Gilles Patrigeon
Frédérique Pavillard
Sabine Peghaire
Christophe Perdrix
Jean-Sebastien Petit
Judith Pibre
Walter Picard
Sylvie Picault
Santiago Picos Gil
Jérôme Pillot
Patrick Pina
Rémi Plattier
Laurent Poiron
Christian Pommier
Gaël Pradel
Cristian Prelipcean
Paul-Simon Pugliesi
Vincent Quenee
Olga Raposo
Eve Remy
Sabine Reynaud Deforges
Jean-Christophe Richard
Sylvie Ricome
Thomas Rimmele
Adrien Robine
Anne-Claude Roche
Laetitia Rohr
Gwenaël Rolland-Jacob
Adrien Roques
Catherine Rougier
Jérôme Roustan
Mélanie Saint-Leger
Faouzi Saliba
Dominique Sechaud
Amine Si-Ali
Catherine Simac
Georges Simon
Michel Sirodot
Vincent Stoeckel
Philippe Tagawa
Marine Tasle
Fabrice Thiollière
Benoit Thiphagne
Aurélie Thomas-Hervieu
François Tinturier
Alexandre Tonnelier
Alexandre Toro
David Tranvan
Dominique Trivier
Gilles Troché
Rémi Trusson
Lionel Ursulet
Marie Laure Valdeyron
Catherine Vallet
Vanessa van Rossem
Laurence Vasse
Myriam Venelle
Christine Venot
Antoine Vieillard-Baron
Jean-François Vincent
Michel Vitris
Hussein Yassine
Lassane Zanre
Cecile Zylberfajn
Publication Details: Critical Care, Vol.28(1)
Identifiers: 9934957609311
Academic Unit: Hydrosciences Montpellier - HSM
Language: English
Resource Type: Journal article
Local Fields: hal-04927359