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Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.
Journal article   Peer reviewed

Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness.

María P Jiménez de Bagüés, Antoine Gross, Annie Terraza and Jacques Dornand
Infection and Immunity, Vol.73(5), pp.3178-83
05/2005
DOI: https://doi.org/10.1128/IAI.73.5.3178-3183.2005
PMCID: PMC1087367
PMID: 15845529

Abstract

Animals Brucella Mice, Inbred BALB C Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Phenotype Virulence p38 Mitogen-Activated Protein Kinases Brucellosis Cell Line Enzyme Activation Gene Expression Regulation Lipopolysaccharides Macrophage Activation Macrophages Mice
By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of immune mediators that regulate host defense. We conclude that the MAPKs are a target for immune intervention by virulent smooth Brucella.
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