Résumé
Introduction: New-onset diabetes mellitus (NODM) has important implications for long-term outcome following liver transplantation.
Aim: To evaluate the impact of conversion from tacrolimus to cyclosporine in liver transplant patients presenting NODM.
Method: In a 12-month pilot study, 39 liver transplant patients with NODM were converted from tacrolimus to cyclosporine. Most patients (59%) were receiving antidiabetic therapy (18% insulin, 41% oral) and all patients had received dietary advice prior to the study.
Results: At month 12, NODM had significantly resolved (FBG < 7 mmol/L without treatment) in 36% of patients (95% CI 20.8-51.0%). In the 16 patients not receiving antidiabetic drugs at baseline, mean FBG decreased from 8.1 mmol/L to 6.6 mmol/L (P = 0.008) and mean HbA(1c) decreased from 6.4 to 6.0% (P = 0.05). Steroids were stopped rapidly in the nine patients receiving steroids at inclusion but NODM resolution was observed in only one of these nine patients. No significant factors were identified that could have affected NODM resolution. There were three episodes of biopsy-proven acute rejection (7.7%), no graft losses and one death. Overall, cyclosporine tolerance was good with no significant change in creatinine clearance at month 12. Total cholesterol increased from 4.6 mmol/L to 5.1 mmol/L (P < 0.001).