Résumé
Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O-2(center dot-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O-2(center dot-) determinants in this population. O-2(center dot) production was evaluated using chemiluminescence method in 136 CKD patients (79M/57F, median age: 69.5 [27.4-94.6]). Renal function (evaluated by the glomerular filtration rate using modification of diet in renal disease (MDRD)), inflammation, lipids, nutritional and bone mineral as well as clinical parameters were evaluated. Potential relationships between O-2(center dot) and these clinico-biological parameters were investigated to identify main determinants of such a pathological process. Enhanced O-2(center dot-) production has been observed at the pre-dialysis phase: stages 4 and 5 of CKD (p = 0.0065). In multivariate analysis, low eGFR (MDRD < 30 mL/min/1.73 m(2); p = 0.046), high fibrinogen (>= 3.7 g/L; p = 0.044) and abnormal HDL cholesterol (< 1.42 mmol/L and >= 1.75 mmol/L; p = 0.042) were the main determinants of O-2(center dot-) production in CKD patients.