Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

Gema Ruiz-Hurtado; Linwei Li; María Fernández-Velasco; Angélica Rueda; Florence Lefebvre; Yueyi Wang; Philippe Mateo; Cécile Cassan; Barnabas Gellen; Jean Pierre Benitah; Ana María Gómez

doi:10.1085/jgp.201511366

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Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

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Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

Gema Ruiz-Hurtado, Linwei Li, María Fernández-Velasco, Angélica Rueda, Florence Lefebvre, Yueyi Wang, Philippe Mateo, Cécile Cassan, Barnabas Gellen, Jean Pierre Benitah, …

Journal of General Physiology, Vol.146(4), pp.295-306

01/10/2015

DOI: https://doi.org/10.1085/jgp.201511366

PMCID: PMC4586588

PMID: 26371209

Résumé

NCX

excitation-contraction

FDHM

full duration at half-maximum

FWHM

full width at half-maximum

heart failure

sodium-calcium exchanger

PLB

phospholamban

PMI

post-myocardial infarction

SERCA

sarco-endoplasmic reticulum Ca 2+ ATPase

NCX

Cardiovascular disease is the leading cause of death in the world (Dahlöf, 2010; Lloyd-Jones, 2010). Heart failure (HF) supports an important percentage of the cardiovascular diseases with serious clinical complications including cardiac arrhythmias, in many cases derived from calcium (Ca 2+)-handling impairment. Among others, Ca 2+ is a key factor of electrical activation, ion channel gating, and excitation-contraction (EC) coupling in the cardiac muscle. During cardiac EC coupling, Ca 2+ influx via sarcolemmal L-type Ca 2+ channels triggers Ca 2+

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Détails

Titre: Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes
Créateurs - sans rôle: Gema Ruiz-Hurtado - Research Institute Hospital 12 de Octubre
Linwei Li - Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
María Fernández-Velasco - Hospital Universitario La Paz
Angélica Rueda - Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
Florence Lefebvre - Inserm
Yueyi Wang - Inserm
Philippe Mateo - Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
Cécile Cassan - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Barnabas Gellen - Inserm
Jean Pierre Benitah - Signalisation et physiopathologie cardiaque
Ana María Gómez - Inserm
Détails de publication: Journal of General Physiology, Vol.146(4), pp.295-306
Identifiants: 99161049909311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03095795