Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients

Flavia K Borges; Mohit Bhandari; Ameen Patel; Victoria Avram; Ernesto Guerra-Farfán; Alben Sigamani; Masood Umer; Maria Tiboni; Anthony Adili; John Neary; Vikas Tandon; Parag K Sancheti; AbdelRahman Lawendy; Richard Jenkinson; Mmampapatla Ramokgopa; Bruce M Biccard; Wojciech Szczeklik; Chew Yin Wang; Giovanni Landoni; Patrice Forget; Ekaterine Popova; Gavin Wood; Aamer Nabi Nur; Bobby John; Paweł Ślęczka; Robert J Feibel; Mariano Balaguer-Castro; Benjamin Deheshi; Mitchell Winemaker; Justin de Beer; Richard Kolesar; Jordi Teixidor-Serra; Jordi Tomas-Hernandez; Michael McGillion; Harsha Shanthanna; Iain Moppett; Jessica Vincent; Shirley Pettit; Valerie Harvey; Leslie Gauthier; Kim Alvarado; P J Devereaux

doi:10.1136/bmjopen-2018-028537

$Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients$

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Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients

Flavia K Borges, Mohit Bhandari, Ameen Patel, Victoria Avram, Ernesto Guerra-Farfán, Alben Sigamani, Masood Umer, Maria Tiboni, Anthony Adili, John Neary, …

BMJ open, Vol.9(4), p.e028537

01/05/2019

DOI: https://doi.org/10.1136/bmjopen-2018-028537

PMID: 31048449

Résumé

IntroductionAnnually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%–10% at 30 days and 10%–20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial—HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications.Methods and analysisHIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients ≥45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients.Ethics and disseminationAll centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources.Trial registration number NCT02027896; Pre-results.

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Titre: Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients
Créateurs - sans rôle: Flavia K Borges - Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada
Mohit Bhandari - Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Ameen Patel - Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Victoria Avram - Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Ernesto Guerra-Farfán - Department of Orthopaedic Surgery and Traumatology, Vall d’Hebron University Hospital, Barcelona, Spain
Alben Sigamani - Department of Clinical Research, Narayana Health, Bangalore, India
Masood Umer - Department of Orthopaedic Surgery, Aga Khan University, Karachi, Pakistan
Maria Tiboni - Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Anthony Adili - Department of Surgery, McMaster University, Hamilton, Ontario, Canada
John Neary - Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Vikas Tandon - Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Parag K Sancheti - Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation, Pune, India
AbdelRahman Lawendy - Department of Surgery, London Health Sciences Centre, London, Ontario, Canada
Richard Jenkinson - Department of Surgery and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
Mmampapatla Ramokgopa - University of the Witwatersrand, Johannesburg, South Africa
Bruce M Biccard - Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa
Wojciech Szczeklik - Department of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland
Chew Yin Wang - Department of Anaesthesiology, University of Malaya, Kuala Lumpur, Malaysia
Giovanni Landoni - Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy
Patrice Forget - Department of Anesthesiology and Perioperative Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium
Ekaterine Popova - Biomedical Research Institute (IIB – SANT PAU), Barcelona, Spain
Gavin Wood - Department of Surgery, Queen’s University, Kingston, Ontario, Canada
Aamer Nabi Nur - Shifa International Hospital, Islamabad, Pakistan
Bobby John - Department of Orthopaedic Surgery, Christian Medical College, Ludhiana, India
Paweł Ślęczka - Orthopaedics, SPZOZ, Myslenice, Poland
Robert J Feibel - Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada
Mariano Balaguer-Castro - Department of Orthopaedic Surgery and Traumatology, Parc Taulí Hospital Universitari, Barcelona, Spain
Benjamin Deheshi - Department of Orthopaedics, Sharif Surgical Oncology, Fort Worth, Texas, USA
Mitchell Winemaker - Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Justin de Beer - Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Richard Kolesar - Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
Jordi Teixidor-Serra - Department of Orthopaedic Surgery and Traumatology, Vall d’Hebron University Hospital, Barcelona, Spain
Jordi Tomas-Hernandez - Department of Orthopaedic Surgery and Traumatology, Vall d’Hebron University Hospital, Barcelona, Spain
Michael McGillion - McMaster University
Harsha Shanthanna - Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
Iain Moppett - Department of Anaesthesia & Critical Care, University of Nottingham, Nottingham, UK
Jessica Vincent - Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada
Shirley Pettit - Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada
Valerie Harvey - Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada
Leslie Gauthier - Hamilton Health Sciences, Hamilton, Ontario, Canada
Kim Alvarado - School of Nursing, McMaster University, Hamilton, Canada
P J Devereaux - McMaster University
Détails de publication: BMJ open, Vol.9(4), p.e028537
Identifiants: 99153954209311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article