Résumé
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK
− cell line, which proves 5′-AZTMP delivery.
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as the nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in the TK
− cell line, which proves 5′-AZTMP delivery.