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Rational design of a new series of mixed anti-HIV pronucleotides
Article de revue   Avec comité de lecture

Rational design of a new series of mixed anti-HIV pronucleotides

Nathalie Schlienger, Thierry Beltran, Christian Périgaud, Isabelle Lefebvre, Alain Pompon, Anne-Marie Aubertin, Gilles Gosselin et Jean-Louis Imbach
Bioorganic & medicinal chemistry letters, Vol.8(21), pp.3003-3006
03/11/1998
DOI: https://doi.org/10.1016/S0960-894X(98)00535-6
PMID: 9873664

Résumé

Antivirals Nucleotides Phosphoric acids and derivatives
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5′-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.

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