REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Petra Seibold; Adam Webb; Miguel Aguado-Barrera; David Azria; Celine Bourgier; Muriel Brengues; Erik Briers; Renée Bultijnck; Patricia Calvo-Crespo; Ana Carballo; Ananya Choudhury; Alessandro Cicchetti; Johannes Claßen; Elena Delmastro; Alison Dunning; Rebecca Elliott; Laura Fachal; Marie-Pierre Farcy-Jacquet; Pietro Gabriele; Elisabetta Garibaldi; Antonio Gómez-Caamaño; Sara Gutiérrez-Enríquez; Daniel Higginson; Kerstie Johnson; Ramón Lobato-Busto; Meritxell Mollà; Anusha Müller; Debbie Payne; Paula Peleteiro; Giselle Post; Tiziana Rancati; Tim Rattay; Victoria Reyes; Barry Rosenstein; Dirk de Ruysscher; Maria Carmen de Santis; Jörg Schäfer; Thomas Schnabel; Elena Sperk; R Paul Symonds; Hilary Stobart; Begoña Taboada-Valladares; Christopher Talbot; Riccardo Valdagni; Ana Vega; Liv Veldeman; Tim Ward; Christian Weißenberger; Catharine West; Jenny Chang-Claude; R. Paul Symonds; Catharine M.L. West; Yolande Lievens; Marc van Eijkeren; Katrien Vandecasteele; Elhaseen Elhamin; Piet Ost; Valérie Fonteyne; Martijn Swimberghe; Pieter Deseyne; Wilfried de Neve; Fréderic Duprez; Marcus Mareel; Chris Monten; Annick van Greveling; Tom Vercauteren; Leen Paelinck; Gilles Defraene; Rita Aerts; Soumia Arredouani; Maarten Lambrecht; Ben Vanneste; Roxana Draghici; Frank Giordano; Carsten Herskind; Marlon Veldwijk; Irmgard Helmbold; Ulrich Giesche; Petra Stegmaier; Christian Weiß; Thomas Blaschke; Burkhard Neu; Laura Lozza; Barbara Avuzzi; Sara Morlino; Claudia Sangalli; Marzia Franceschini; Belina Rodriguez-Lage; Juan Fernández-Tajes; Olivia Fuentes-Rios; Isabel Domínguez-Rios; Irene Fajardo-Paneque; Paloma Sosa-Fajardo; Laura Torrado-Moya; Mónica Ramos-Albiac; Alexandra Giraldo; Manolo Altabas; Bibiana Piqué-Leiva; David García-Relancio; Alejandro Seoane-Ramallo; Samuel Lavers; Simon Wright; Hannah Dobbelaere; Donna Appleton; Monika Kaushik; Frances Kenny; Hazem Khout; Jaroslaw Krupa; Kelly Lambert; Simon Pilgrim; Sheila Shokuhi; Kalliope Valassiadou; Luis Aznar-Garcia; Ion Boiangui; Kiran Kancherla; Christopher Kent; Kufre Sampson; Ahmed Osman; Thiagarajan Sridhar; Subramaniam Vasanthan; Corinne Faivre-Finn; Victoria Harrop; Manjusha Keni; Karen Foweraker; Abigail Pascoe; Claire Esler; Richard Stock; Sheryl Green; Ava Golchin; William Li

doi:10.1016/j.radonc.2019.04.034

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REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Journal article

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REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Petra Seibold, Adam Webb, Miguel Aguado-Barrera, David Azria, Celine Bourgier, Muriel Brengues, Erik Briers, Renée Bultijnck, Patricia Calvo-Crespo, Ana Carballo, …

Radiotherapy & Oncology, Vol.138, pp.59-67

09/2019

DOI: https://doi.org/10.1016/j.radonc.2019.04.034

PMID: 31146072

Abstract

Biomarkers

Breast cancer

Late radiotherapy side effects

Lung cancer

Prediction models

Prostate cancer

Adult

Aged

Prospective Studies

Prostatic Neoplasms

Aged, 80 and over

Breast Neoplasms

Cohort Studies

Female

Humans

Lung Neoplasms

Male

Middle Aged

Purpose: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data.Methods: An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated.Results: The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician- (47,025 forms) and patient- (54,901) reported outcomes; 11,563 breast photos; 17,107 DICOMs and 12,684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA (n = 4409) and PAXgene tubes (n = 3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade ≥2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung).Conclusion: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers.

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Title: REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer
Creators - without role: Petra Seibold - German Cancer Research Center
Adam Webb - University of Leicester
Miguel Aguado-Barrera - Fundación Pública Galega de Medicina Xenómica
David Azria - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Celine Bourgier - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Muriel Brengues - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Erik Briers
Renée Bultijnck - Ghent University
Patricia Calvo-Crespo
Ana Carballo - Complejo Hospitalario Universitario de Santiago
Ananya Choudhury - Manchester Academic Health Science Centre
Alessandro Cicchetti - Fondazione IRCCS Istituto Nazionale dei Tumori
Johannes Claßen - St. Vincentius-Kliniken
Elena Delmastro - Candiolo Cancer Institute
Alison Dunning - MRC Epidemiology Unit
Rebecca Elliott - Manchester Academic Health Science Centre
Laura Fachal - MRC Epidemiology Unit
Marie-Pierre Farcy-Jacquet
Pietro Gabriele - Candiolo Cancer Institute
Elisabetta Garibaldi - Candiolo Cancer Institute
Antonio Gómez-Caamaño - Instituto de Investigación Sanitaria de Santiago
Sara Gutiérrez-Enríquez - Vall d'Hebron Institute of Oncology
Daniel Higginson - Memorial Sloan Kettering Cancer Center
Kerstie Johnson - University of Leicester
Ramón Lobato-Busto - Complejo Hospitalario Universitario de Santiago
Meritxell Mollà - Vall d'Hebron Hospital Universitari
Anusha Müller - German Cancer Research Center
Debbie Payne - University of Manchester
Paula Peleteiro - Complejo Hospitalario Universitario de Santiago
Giselle Post - Ghent University
Tiziana Rancati - Fondazione IRCCS Istituto Nazionale dei Tumori
Tim Rattay - University of Leicester
Victoria Reyes - Vall d'Hebron Hospital Universitari
Barry Rosenstein - Icahn School of Medicine at Mount Sinai
Dirk de Ruysscher - Maastro Clinic
Maria Carmen de Santis - Fondazione IRCCS Istituto Nazionale dei Tumori
Jörg Schäfer
Thomas Schnabel - Klinikum Ludwigshafen
Elena Sperk - Heidelberg University
R Paul Symonds - University of Leicester
Hilary Stobart - The Patients Association
Begoña Taboada-Valladares - Complejo Hospitalario Universitario de Santiago
Christopher Talbot
Riccardo Valdagni - Fondazione IRCCS Istituto Nazionale dei Tumori
Ana Vega - Fundación Pública Galega de Medicina Xenómica
Liv Veldeman - Ghent University Hospital
Tim Ward
Christian Weißenberger
Catharine West - Manchester Academic Health Science Centre
Jenny Chang-Claude - German Cancer Research Center
R. Paul Symonds - University of Leicester
Catharine M.L. West
Yolande Lievens
Marc van Eijkeren
Katrien Vandecasteele
Elhaseen Elhamin
Piet Ost - Ghent University
Valérie Fonteyne
Martijn Swimberghe
Pieter Deseyne
Wilfried de Neve
Fréderic Duprez
Marcus Mareel
Chris Monten
Annick van Greveling
Tom Vercauteren
Leen Paelinck
Gilles Defraene
Rita Aerts
Soumia Arredouani
Maarten Lambrecht
Ben Vanneste
Roxana Draghici
Frank Giordano
Carsten Herskind
Marlon Veldwijk
Irmgard Helmbold
Ulrich Giesche
Petra Stegmaier - German Cancer Research Center
Christian Weiß
Thomas Blaschke - Klinikum Ludwigshafen
Burkhard Neu
Laura Lozza - MRC Epidemiology Unit
Barbara Avuzzi
Sara Morlino - Vall d'Hebron Institute of Oncology
Claudia Sangalli
Marzia Franceschini
Belina Rodriguez-Lage
Juan Fernández-Tajes
Olivia Fuentes-Rios
Isabel Domínguez-Rios
Irene Fajardo-Paneque
Paloma Sosa-Fajardo
Laura Torrado-Moya - MRC Epidemiology Unit
Mónica Ramos-Albiac
Alexandra Giraldo
Manolo Altabas
Bibiana Piqué-Leiva
David García-Relancio - Institut de Recherche en Cancérologie de Montpellier
Alejandro Seoane-Ramallo
Samuel Lavers
Simon Wright
Hannah Dobbelaere
Donna Appleton
Monika Kaushik
Frances Kenny
Hazem Khout
Jaroslaw Krupa
Kelly Lambert
Simon Pilgrim
Sheila Shokuhi
Kalliope Valassiadou
Luis Aznar-Garcia
Ion Boiangui
Kiran Kancherla
Christopher Kent - University of Leicester
Kufre Sampson
Ahmed Osman
Thiagarajan Sridhar
Subramaniam Vasanthan
Corinne Faivre-Finn
Victoria Harrop - Vall d'Hebron Hospital Universitari
Manjusha Keni
Karen Foweraker
Abigail Pascoe
Claire Esler
Richard Stock
Sheryl Green
Ava Golchin - Complejo Hospitalario Universitario de Santiago
William Li - Ghent University Hospital
Publication Details: Radiotherapy & Oncology, Vol.138, pp.59-67
Identifiers: 9941750609311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM
Language: English
Resource Type: Journal article
Local Fields: hal-05070686