Résumé
Because the entire genome of Caenorhabditis elegans (C. elegans) is available for exploration since 1998, several information have been retrieved about the global interest of this organism when it became apparent that the similarity of genes in this I nun length nematode and those in humans is remarkable. with approximately 67% of genes that are associated with human disease having homologues in the worm genome. C. elegans worms call be easily maintained on various food-sources and culture media allowing testing for molecules or treatments in combination with different genetic mutants backgrounds as well as RNA interference (RNAi). Because of regulatory pathways conservation between humans and worms, several interesting strategies can be developed to facilitate drugs screenings oil specific targets as well as to decipher complex physiological programmed traits with potential identification of new therapeutic targets interesting for human health. By using specific examples, we propose to introduce how to use the already available C elegans data-cross that can be used as it basis for developing new therapeutic targets, identification strategies. (C) 2008 Elsevier Masson SAS. Tous droits reserves.