Abstract
Objective: This prospective cohort study examines whether purpose in life is associated with markers of immunity and inflammation and tests these markers as mediators between purpose and episodic memory.Methods: Participants from the Venous Blood Study of the Health and Retirement Study reported on their purpose in life, had their blood assayed for markers of immunity and inflammation, and were administered an episodic memory task (N=8,999). Regression analyses tested the association between purpose and each marker. Prospective mediation analyses (N=6,092) tested whether these markers measured in 2016 were mediators between purpose measured in 2012/2014 and episodic memory measured in 2018.Results: Higher purpose in life was associated with lower neutrophil counts (β=−.08, p<.001), lower ratio of neutrophils/lymphocytes (β=−.05, p<.001), and lower systemic immune inflammation index (β=−.04, p<.001); purpose was unrelated to monocyte, platelet, and lymphocyte counts or the ratio of platelets/lymphocytes (all ns). Purpose was associated negatively with c-reactive protein (β=−.07, p<.001), Interleukin-6 (β=−.08, p<.001), Interleukin-10 (β=−.07, p<.001), Interleukin-1ra (β=−.08, p<.001), and soluble Tumor Necrosis Factor Receptor 1 (sTNFR1; β=−.10, p<.001); purpose was unrelated to Transforming Growth Factor beta 1. These associations were largely not moderated by age, sex, race, ethnicity, and education. Lower neutrophils, Interleukin-6, and sTNFR1 were associated prospectively with better episodic memory and mediated the association between purpose and episodic memory.Conclusion: Purpose in life is associated with markers of immunity and inflammation, some of which are one mechanism in the pathway between purpose and healthier episodic memory.