Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

Jean-François Guichou; Luc Patiny; Manfred Mutter

doi:10.1016/S0040-4039(02)00755-4

Retour

Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

Article de revue

Avec comité de lecture

Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

Jean-François Guichou, Luc Patiny et Manfred Mutter

Tetrahedron letters, Vol.43(24), pp.4389-4390

10/06/2002

DOI: https://doi.org/10.1016/S0040-4039(02)00755-4

Résumé

The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (ΨPro) derivatives by intraresidual N, S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure–activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys] 8CsA. Graphic

Indicateurs

1 Consultations de la notice

Détails

Titre: Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides
Créateurs - sans rôle: Jean-François Guichou
Luc Patiny
Manfred Mutter
Détails de publication: Tetrahedron letters, Vol.43(24), pp.4389-4390
Éditeur: Elsevier Ltd
Nombre de pages: 2
Identifiants: 99136047209311
Unité académique: Centre de Biologie Structurale - CBS
Langue: English
Type de ressource: Journal article