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Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with Shared Properties
Article de revue   Open Access   Avec comité de lecture

Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with Shared Properties

Barbara Lonetti, Steve Bourgault, Joseph Chamieh, Hervé Cottet, François Couderc, Christophe Mingotaud, Patricia Vicendo, Anne-Françoise Mingotaud et Fabrice Collin
Biomacromolecules
19/01/2026
PMID: 41552839

Résumé

Polymer self-assembly proteins peptides neurodegenerative
This publication constitutes a comparison of two apparently different communities, namely that of synthetic polymer self-assemblies and that of amyloid aggregates to cross-fertilize each other. The starting point is shared recognized issues in reproducibility of fabrication of the aggregates for each community. Based on this, this publication compares the underlying mechanistic principles of self-assembly, the methods for the preparation of assemblies, and the techniques used for their characterization. This highlights some common practices but also different ones. Interestingly, some techniques may be used by both communities but with different perspectives and aims, whereas others are preferably employed by one community. The article finally suggests possible cross-advice for each one.

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