Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Antoine Vasseur; Luc Cabel; Olivier Trédan; Marion Chevrier; Coraline Dubot; Veronique Lorgis; William Jacot; Anthony Gonçalves; Marc Debled; Christelle Lévy; Jean-Marc Ferrero; Christelle G Jouannaud; Elisabeth Luporsi; Marie-Ange Mouret-Reynier; Florence Dalenc; Jérôme Lemonnier; Alexia Savignoni; Marie-Laure Tanguy; François-Clément Bidard; Jean-Yves Pierga

doi:10.1007/s10456-019-09697-7

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Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

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Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Antoine Vasseur, Luc Cabel, Olivier Trédan, Marion Chevrier, Coraline Dubot, Veronique Lorgis, William Jacot, Anthony Gonçalves, Marc Debled, Christelle Lévy, …

Angiogenesis, Vol.23(2), pp.193-202

05/2020

DOI: https://doi.org/10.1007/s10456-019-09697-7

PMID: 31773439

Abstract

Bevacizumab

Breast cancer

Circulating endothelial cells

Proof of concept studies has reported that circulating endothelial cell (CEC) count may be associated with the outcome of HER2-negative metastatic breast cancer (mBC) patients treated by chemotherapy and the anti-VEGF antibody bevacizumab. We report the results obtained in an independent prospective validation cohort (COMET study, NCT01745757).

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Title: Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)
Creators - without role: Antoine Vasseur - Université Paris Sciences et Lettres
Luc Cabel - Université Paris Sciences et Lettres
Olivier Trédan - Centre Léon Bérard
Marion Chevrier - Institut Curie
Coraline Dubot - Université Paris Sciences et Lettres
Veronique Lorgis - Centre Georges François Leclerc
William Jacot - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Anthony Gonçalves - Centre National de la Recherche Scientifique
Marc Debled - Institut Bergonié
Christelle Lévy - Centre François Baclesse
Jean-Marc Ferrero - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
Christelle G Jouannaud - Institut Jean Godinot
Elisabeth Luporsi - Institut de Cancérologie de Lorraine
Marie-Ange Mouret-Reynier - Imagerie Moléculaire et Stratégies Théranostiques
Florence Dalenc - Institut Claudius Regaud
Jérôme Lemonnier - UniCancer Group
Alexia Savignoni - Université Paris Sciences et Lettres
Marie-Laure Tanguy - Charmo University
François-Clément Bidard - Service d'Oncologie Médicale
Jean-Yves Pierga - Service d'Oncologie Médicale
Publication Details: Angiogenesis, Vol.23(2), pp.193-202
Identifiers: 9940874009311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM
Language: English
Resource Type: Journal article
Local Fields: hal-02888436