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Prognostic Value of Trop-2 Expression in Nonmetastatic Triple-Negative Breast Cancer and Correlation With Emerging Biomarkers.
Journal article   Open access   Peer reviewed

Prognostic Value of Trop-2 Expression in Nonmetastatic Triple-Negative Breast Cancer and Correlation With Emerging Biomarkers.

William Jacot, Marie-Christine Chateau, Simon Thezenas, Séverine Guiu, Nelly Firmin, Virginie Lafont, Charles Theillet and Florence Boissière-Michot
Cancer Medicine, Vol.14(5)
01/03/2025
DOI: https://doi.org/10.1002/cam4.70615
PMID: 40059728

Abstract

Trop‐2 basal‐like expression molecular apocrine prognosis triple‐negative breast cancer Humans Triple Negative Breast Neoplasms Biomarkers, Tumor Prognosis Middle Aged Adult Aged Retrospective Studies Immunohistochemistry Animals Aged, 80 and over Mice Cell Adhesion Molecules Female Antigens, Neoplasm
Triple-Negative Breast Cancer (TNBC) is an aggressive breast cancer subtype, in which targeting the Trophoblast cell-surface antigen-2 (Trop-2), using antibody-drug conjugates (ADC), results in significant clinical improvement. However, clinicopathological correlations with Trop-2 protein expression levels remain limited in TNBC patients.
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