Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Javier Villacieros-Álvarez; Carmen Espejo; Georgina Arrambide; Alessandro Dinoto; Patricia Mulero; Laura Rubio-Flores; Pablo Nieto; Carmen Alcalá; Jose E Meca-Lallana; Jorge Millan-Pascual; Pedro Martínez-García; Raphael Bernard-Valnet; Inés González-Suárez; Aída Orviz; Raquel Téllez; Laura Navarro Cantó; Silvia Presas-Rodríguez; Sergio Martínez-Yélamos; Juan Pablo Cuello; Ana Alonso; Raquel Piñar Morales; Gary Álvarez Bravo; Lakhdar Benyahya; Sophie Trouillet-Assant; Virginie Dyon-Tafan; Caroline Froment Tilikete; Aurélie Ruet; Bertrand Bourre; Romain Deschamps; Caroline Papeix; Elisabeth Maillart; Philippe Kerschen; Xavier Ayrignac; Àlex Rovira; Cristina Auger; Bertrand Audoin; Xavier Montalban; Mar Tintore; Sara Mariotto; Alvaro Cobo-Calvo; Romain Marignier

doi:10.1212/NXI.0000000000200362

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Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Javier Villacieros-Álvarez, Carmen Espejo, Georgina Arrambide, Alessandro Dinoto, Patricia Mulero, Laura Rubio-Flores, Pablo Nieto, Carmen Alcalá, Jose E Meca-Lallana, Jorge Millan-Pascual, …

Neurology : neuroimmunology & neuroinflammation, Vol.12(2), p.e200362

01/03/2025

DOI: https://doi.org/10.1212/NXI.0000000000200362

PMID: 39752619

Résumé

Adolescent

Adult

Autoantibodies - blood

Cytokines - blood

Demyelinating Autoimmune Diseases, CNS - blood

Demyelinating Autoimmune Diseases, CNS - diagnosis

Demyelinating Autoimmune Diseases, CNS - immunology

Female

Follow-Up Studies

Humans

Male

Middle Aged

Multiple Sclerosis - blood

Multiple Sclerosis - immunology

Myelin-Oligodendrocyte Glycoprotein - immunology

Prognosis

Retrospective Studies

Young Adult

To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability. This retrospective multicentric cohort study included patients aged 16 years and older meeting MOGAD 2023 criteria, with serum samples collected at baseline (≤3 months from disease onset) and follow-up (≥6 months from the baseline), and age-matched and time to sampling-matched patients with multiple sclerosis (MS). Eleven cytokines were assessed using the ELLA system. Data comparisons and statistical analyses between cytokine levels and clinical outcomes were performed. Eighty-eight patients with MOGAD and 32 patients with MS were included. Patients with MOGAD showed higher IL6 ( = 0.036), IL8 ( = 0.012), and IL18 ( = 0.026) baseline levels compared with those with MS, in non-optic neuritis (ON) presentations. BAFF values increased over time, especially in patients with MOGAD treated with anti-CD20 ( = 0.002). Baseline BAFF, CXCL10, IL10, and IL8 levels correlated with disease severity at MOGAD onset (all < 0.05). Finally, higher baseline BAFF levels predicted lower risk of relapses (hazard ratio 0.41 [0.19; 0.89], = 0.024). This study suggests a proinflammatory Th17-dominant profile in non-ON MOGAD patients, with a novel finding of a potential protective role of BAFF on relapses. These results shed new light on the pathogenesis of MOGAD, potentially guiding therapeutic decisions.

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Titre: Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Créateurs - sans rôle: Javier Villacieros-Álvarez - Universitat Autònoma de Barcelona, Spain
Carmen Espejo - Universitat Autònoma de Barcelona, Spain
Georgina Arrambide - Universitat Autònoma de Barcelona
Alessandro Dinoto - Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy
Patricia Mulero - Hospital Clínico Universitario de Valladolid
Laura Rubio-Flores - Servicio de Neurología, Hospital Universitario Rey Juan Carlos, Madrid, Spain
Pablo Nieto - Servicio de Neurología, Hospital Universitario Rey Juan Carlos, Madrid, Spain
Carmen Alcalá - Unidad de Neuroinmunología, Hospital Universitari i Politècnic La Fe
Jose E Meca-Lallana - Multiple Sclerosis CSUR. Clinical Neuroimmunology Unit, Neurology Department, "Virgen de la Arrixaca" Clinical University Hospital, IMIB-Arrixaca, and NICEM Cathedra, UCAM-San Antonio Catholic University, Murcia, Spain
Jorge Millan-Pascual - Multiple Sclerosis CSUR. Clinical Neuroimmunology Unit, Neurology Department, "Virgen de la Arrixaca" Clinical University Hospital, IMIB-Arrixaca, and NICEM Cathedra, UCAM-San Antonio Catholic University, Murcia, Spain
Pedro Martínez-García - Immunology Department, "Virgen de la Arrixaca" Clinical University Hospital, IMIB-Arrixaca, Murcia, Spain
Raphael Bernard-Valnet - Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland
Inés González-Suárez - Hospital Álvaro Cunqueiro, Vigo
Aída Orviz - Hospital Universitario Fundación Jiménez Díaz, Madrid
Raquel Téllez - Hospital Universitario Fundación Jiménez Díaz, Madrid
Laura Navarro Cantó - Neurología. Hospital General Universitario de Elche, Alicante
Silvia Presas-Rodríguez - MS-Neuroimmunology Unit, Neurosciences Department, Germans Trias i Pujol Hospital
Sergio Martínez-Yélamos - Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge, Neurology and Neurogenetics Group, Neuroscience Program, Department of Clinical Sciences, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)
Juan Pablo Cuello - Hospital General Universitario Gregorio Marañón
Ana Alonso - Hospital Regional Universitario de Málaga
Raquel Piñar Morales - Servicio de Neurologia. Hospital Universitario Clinico San Cecilio, Granada, Spain
Gary Álvarez Bravo - Unitat de Neuroimmunologia i Esclerosi Múltiple Territorial Girona (UNIEMTG), Hospital Universitari de Girona Dr. Josep Trueta | Hospital Santa Caterina, Girona, Spain
Lakhdar Benyahya - Hospices Civils de Lyon
Sophie Trouillet-Assant - Hospices Civils de Lyon
Virginie Dyon-Tafan - Joint Research Unit Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Bénite
Caroline Froment Tilikete - Hospices Civils de Lyon, Service de Neuro-Ophtalmologie-Hôpital Neurologique Pierre Wertheimer, Bron Cedex
Aurélie Ruet - Centre Hospitalier Universitaire de Bordeaux
Bertrand Bourre - CHU-Hôpitaux de Rouen
Romain Deschamps - Foundation Adolphe de Rothschild Hospital
Caroline Papeix
Elisabeth Maillart
Philippe Kerschen - Centre Hospitalier de Luxembourg, Luxembourg-Ville
Xavier Ayrignac - Montpellier University Hospital
Àlex Rovira - Vall d'Hebron Institut de Recerca
Cristina Auger - Section of Neuroradiology, Department of Radiology (IDI), Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Bertrand Audoin
Xavier Montalban - Universitat de Vic, Spain
Mar Tintore - Universitat Autònoma de Barcelona
Sara Mariotto - University of Verona
Alvaro Cobo-Calvo - Universitat Autònoma de Barcelona, Spain
Romain Marignier - Hospices Civils de Lyon, Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation-Hôpital Neurologique Pierre Wertheimer, Bron Cedex
Détails de publication: Neurology : neuroimmunology & neuroinflammation, Vol.12(2), p.e200362
Identifiants: 99155136309311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article