Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

Aboud Kourieh; Tarik Gheit; Massimo Tommasino; Veronique Dalstein; Gary M. Clifford; Jean Lacau St Guily; Christine Clavel; Silvia Franceschi; Jean-Damien Combes; Sebastien Albert; Beatrix Barry; Muriel Hourseau; Annabelle Picard; Dominique Berrebi; Thierry Van Den Abbeele; Natacha Teissier; Francoise Denoyelle; Louise Galmiche-Rolland; Nicolas Leboulanger; Vincent Couloigner; Olivier de Crouy-Chanel; Marine Lefevre; Maria Lesnik; Sophie Perie; Sabine Samaha; Aurore Coulomb; Yves Denoux; Jean-Michel Badet; Olivier Mauvais; Christiane Mougin; Jean-Luc Pretet; Severine Valmary-Degano; Emmanuel Babin; Emmanuelle Lechapt-Zalchman; Elisabeth Brambilla; Sylvie Lantuejoul; Christian Righini; Jean-Pierre Bessede; Bema Coulibaly; Justine Lerat; Francoise Berger; Alexandra Traverse-Glehen; Philippe Ceruse; Alain Cosmidis; Valerie Costes; Renaud Garrel; Elisabeth Cassagnau; Olivier Malard; Heliette Chapuis; Benjamin Lallemant; Xavier Dufour; Eric Frouin; Pierre Levillain; Philippe Birembaut; Stephanie Caudroy; Marie-Daniele Diebold; Jean-Claude Merol; Emmanuelle Uro-Coste; Sebastien Vergez; Sylvain Moriniere; Cecilia Rousselot; Mihaela Onea; Philippe Schultz; Christine Bach; Sandrine McKay-Chopin; SPLIT Study Grp

doi:10.1002/jmv.25338

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Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

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Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

Aboud Kourieh, Tarik Gheit, Massimo Tommasino, Veronique Dalstein, Gary M. Clifford, Jean Lacau St Guily, Christine Clavel, Silvia Franceschi, Jean-Damien Combes, Sebastien Albert, …

Journal of medical virology, Vol.91(4), pp.687-697

04/2019

DOI: https://doi.org/10.1002/jmv.25338

PMID: 30318627

Résumé

Life Sciences & Biomedicine

Science & Technology

Virology

Objective To assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age-stratified large sample of immunocompetent children and adults. Methods Patients undergoing tonsillectomy for benign indications were recruited in 19 French hospitals. After resection, the entire outer surfaces of right and left half tonsils were extensively brushed. A highly sensitive species-specific multiplex assay was used to detect herpes simplex virus 1 (HSV1), HSV2, Epstein-Barr virus (EBV; types 1 and 2), and human cytomegalovirus (CMV) DNA in 688, as well as varicella zoster virus (VZV), HHV6A, HHV6B, HHV7, and Kaposi's sarcoma-associated herpesvirus (KSHV) DNA in a subset of 440 tonsil brushings. Results Overall 85% of tonsil brushing samples were infected with at least one HHV species. HHV7 and EBV were the most prevalent (approximate to 70%), followed by HHV6B (approximate to 50%), HSV1, CMV, VZV (approximate to 2%), and KSHV and HSV2 (<1%), while HHV6A was not detected. EBV prevalence was significantly higher in adults than in children, whereas it was opposite for HHV6B and VZV. No difference in HHV prevalence was observed by sex. In multivariate analysis, EBV detection was associated with age greater than or equal to 15 years (prevalence ratio [PR] = 1.8; 95% confidence interval [CI]: 1.5-2.3) and marginally with tobacco smoking (PR = 1.2; 95% CI: 1.1-1.3). Conclusion Differing patterns of HHV infection in tonsils in a large age-stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs.

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Titre: Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study
Créateurs - sans rôle: Aboud Kourieh - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
Tarik Gheit - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
Massimo Tommasino - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
Veronique Dalstein - CHU Reims, Hop Maison Blanche, Lab Biopathol, Reims, France
Gary M. Clifford - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
Jean Lacau St Guily - Sorbonne Univ, Fac Med, Dept Otorhinolaryngol & Head & Neck Surg, Paris, France
Christine Clavel - CHU Reims, Hop Maison Blanche, Lab Biopathol, Reims, France
Silvia Franceschi - Aviano Natl Canc Inst, Aviano, Italy
Jean-Damien Combes - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
Sebastien Albert - AP HP Bichat, Paris, France
Beatrix Barry - Assistance Publique – Hôpitaux de Paris
Muriel Hourseau - AP HP Bichat, Paris, France
Annabelle Picard - AP HP Bichat, Paris, France
Dominique Berrebi - Assistance Publique – Hôpitaux de Paris
Thierry Van Den Abbeele - AP HP Debre, Paris, France
Natacha Teissier - AP HP Debre, Paris, France
Francoise Denoyelle - Assistance Publique – Hôpitaux de Paris
Louise Galmiche-Rolland - AP HP Necker, Paris, France
Nicolas Leboulanger - AP HP Necker, Paris, France
Vincent Couloigner - Assistance Publique – Hôpitaux de Paris
Olivier de Crouy-Chanel - AP HP Tenon, Paris, France
Marine Lefevre - AP HP Tenon, Paris, France
Maria Lesnik - AP HP Tenon, Paris, France
Sophie Perie - Assistance Publique – Hôpitaux de Paris
Sabine Samaha - AP HP Tenon, Paris, France
Aurore Coulomb - AP HP Trousseau, Paris, France
Yves Denoux - CH Versailles, Le Chesnay, France
Jean-Michel Badet - CHU Besancon, Besancon, France
Olivier Mauvais - CHU Besancon, Besancon, France
Christiane Mougin - CHU Besancon, Besancon, France
Jean-Luc Pretet - CHU Besancon, Besancon, France
Severine Valmary-Degano - CHU Besancon, Besancon, France
Emmanuel Babin - Centre Hospitalier Universitaire de Caen Normandie
Emmanuelle Lechapt-Zalchman - CHU Caen, Caen, France
Elisabeth Brambilla - CHU Grenoble, Grenoble, France
Sylvie Lantuejoul - CHU Grenoble, Grenoble, France
Christian Righini - CHU Grenoble, Grenoble, France
Jean-Pierre Bessede - CHU Limoges, Limoges, France
Bema Coulibaly - CHU Limoges, Limoges, France
Justine Lerat - CHU Limoges, Limoges, France
Francoise Berger - CHU Lyon, Lyon, France
Alexandra Traverse-Glehen - CHU Lyon, Lyon, France
Philippe Ceruse - CHU Lyon, Lyon, France
Alain Cosmidis - CHU Lyon, Lyon, France
Valerie Costes - CHU Montpellier, Montpellier, France
Renaud Garrel - CHU Montpellier, Montpellier, France
Elisabeth Cassagnau - CHU Nantes, Nantes, France
Olivier Malard - Université de Nantes
Heliette Chapuis - CHU Nimes, Nimes, France
Benjamin Lallemant - CHU Nimes, Nimes, France
Xavier Dufour - CHU Poitiers, Poitiers, France
Eric Frouin - CHU Poitiers, Poitiers, France
Pierre Levillain - Centre Hospitalier Universitaire de Poitiers
Philippe Birembaut - CHU Reims, Reims, France
Stephanie Caudroy - CHU Reims, Reims, France
Marie-Daniele Diebold - CHU Reims, Reims, France
Jean-Claude Merol - CHU Reims, Reims, France
Emmanuelle Uro-Coste - CHU Toulouse, Toulouse, France
Sebastien Vergez - CHU Toulouse, Toulouse, France
Sylvain Moriniere - CHU Tours, Tours, France
Cecilia Rousselot - CHU Tours, Tours, France
Mihaela Onea - CHU Strasbourg, Strasbourg, France
Philippe Schultz - CHU Strasbourg, Strasbourg, France
Christine Bach - Hop Foch Suresnes, Suresnes, France
Sandrine McKay-Chopin - Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France
SPLIT Study Grp
Détails de publication: Journal of medical virology, Vol.91(4), pp.687-697
Éditeur: Wiley
Nombre de pages: 11
Note de subvention: 20111204169 / Association pour la Recherche sur le Cancer; Fondation ARC pour la Recherche sur le Cancer; Australian Research Council 2014/122; 2011/196 / Institut National Du Cancer; Institut National du Cancer (INCA) France
Identifiants: 99148101809311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI; Recherche hors université
Langue: English
Type de ressource: Journal article