Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

R. Helmy; K. Denhaerynck; L. Berben; F. Dobbels; C. L. Russell; B. D. Roza; S. de Geest; M. G. Crespo-Leiro; S. Guppies; P. de Simone; A. Groenewoud; C. Kugler; L. Ohler; J. van Cleemput; A. J. Poncelet; L. Sebbag; M. Michel; A. Bernard; A. Doesch; U. Livi; L. Potena; V. Brossa-Loidi; J. Segovia-Cubero; L. Almenar-Bonet; C. S. Saint-Gerons; P. Mohacsi; E. Horvath; C. Riotto; G. Parry; A. Firouzi; S. Kozuszko; H. Haddad; A. Kaan; G. Fisher; T. Miller; M. Flattery; K. Ludrosky; N. Albert; B. Coleman; J. Trammell; F. Epstein; K. St Clair; A. Kao; M. Molina; K. R. Canales; S. S. De Almeida; A. C. Ayoub; F. Barone; M. Harkess; J. Maddicks-Law; Bright Study Team

doi:10.1016/j.clinthera.2018.11.007

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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

R. Helmy, K. Denhaerynck, L. Berben, F. Dobbels, C. L. Russell, B. D. Roza, S. de Geest, M. G. Crespo-Leiro, S. Guppies, P. de Simone, …

Clin. Ther, Vol.41(1), pp.130--136

2019

DOI: https://doi.org/10.1016/j.clinthera.2018.11.007

Résumé

Pharmacology & Pharmacy

medication adherence

international

immunosuppressants

heart transplantation

cross-sectional

co-medications

adherence

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

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Titre: Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
Créateurs - sans rôle: R. Helmy - University of Basel
K. Denhaerynck - University of Basel
L. Berben - University Hospital of Basel
F. Dobbels - University Hospital of Basel
C. L. Russell - University of Missouri–Kansas City
B. D. Roza
S. de Geest - University of Basel
M. G. Crespo-Leiro - Instituto de Investigación Biomédica de A Coruña
S. Guppies
P. de Simone - Ospedale Cisanello
A. Groenewoud - Astellas Pharma
C. Kugler - Medizinische Hochschule Hannover
L. Ohler - George Washington University
J. van Cleemput
A. J. Poncelet - Cliniques Universitaires Saint-Luc
L. Sebbag - Hôpital Louis Pradel
M. Michel - Hôpital Nord
A. Bernard - Sorbonne Université
A. Doesch - University Hospital Heidelberg
U. Livi - University of Udine
L. Potena - University of Bologna
V. Brossa-Loidi - Hospital de Sant Pau
J. Segovia-Cubero
L. Almenar-Bonet - Hospital Universitari i Politècnic La Fe
C. S. Saint-Gerons - Hospital Universitario Reina Sofía
P. Mohacsi - University Hospital of Bern
E. Horvath - University Hospital of Zurich
C. Riotto - Papworth Hospital
G. Parry - Freeman Hospital
A. Firouzi - Royal Brompton & Harefield NHS Foundation Trust
S. Kozuszko - Toronto General Hospital
H. Haddad - Laboratoire Informatique d'Avignon
A. Kaan - St. Paul's Hospital
G. Fisher - London Health Sciences Centre
T. Miller - Duke University Hospital
M. Flattery - Virginia Commonwealth University
K. Ludrosky - Cleveland Clinic
N. Albert - Cleveland Clinic
B. Coleman - Cedars-Sinai Medical Center
J. Trammell - Kaiser Permanente Santa Clara Medical Center
F. Epstein - Kaiser Permanente Santa Clara Medical Center
K. St Clair
A. Kao - St. Luke's Hospital
M. Molina - Hospital of the University of Pennsylvania
K. R. Canales - Ochsner Medical Center
S. S. De Almeida
A. C. Ayoub - Instituto Dante Pazzanese de Cardiologia
F. Barone - Hospital do Coração
M. Harkess - St Vincent's Hospital Sydney
J. Maddicks-Law - Prince Charles Hospital
Bright Study Team
Détails de publication: Clin. Ther, Vol.41(1), pp.130--136
Identifiants: 99151987809311
Unité académique: Université de Montpellier
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02466558