Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study *

Gonzague Jourdain; Antoni Soriano-Arandes; Intira Collins; Laura Marqués; Elena Chiappini; Luisa Galli; Lars Naver; Diana Gibb; Magdalena Marczynska; Marc Lallemant; Nicole Ngo-Giang-Huong; Ruslan Malyuta; Alla Volokha; Tessa Goetghebuer; Marc Hainaut; Marc Delforge; Josiane Warszawski; Jérôme Le Chenadec; Elisa Ramos; Olivia Dialla; Thierry Wack; Corine Laurent; Lamya Ait Si Selmi; Isabelle Leymarie; Fazia Ait Benali; Maud Brossard; Leila Boufassa; Corinne Floch-Tudal; Ghislaine Firtion; Isabelle Hau; Anne Chace; Pascal Bolot; Stephane Blanche; Martine Levine; Le Kremlin Bicëtre; Corinne Fourcade; Brigitte Heller-Roussin; Camille Runel-Belliard; Joëlle Tricoire; Catherine Chirouze; Véronique Reliquet; Jacques Brouard; Kamila Kebaili; Pascale Fialaire; Muriel Lalande; Stephan Schultze-Strasser; U Baumann; T Niehues; J Neubert; R Kobbe; Charite Berlin; C Feiterna-Sperling; Christoph Königs; B Buchholz; G Notheis; Vana Spoulou; Maurizio de Martino; Pier Angelo Tovo; Osimani Patrizia; Domenico Larovere; Maurizio Ruggeri; Giacomo Faldella; Francesco Baldi; Raffaele Badolato; Carlotta Montagnani; Elisabetta Venturini; Catiuscia Lisi; Antonio Di Biagio; Lucia Taramasso; Vania Giacomet; Paola Erba; Susanna Esposito; Rita Lipreri; Filippo Salvini; Claudia Tagliabue; Monica Cellini; Eugenia Bruzzese; Andrea Lo Vecchio; Osvalda Rampon; Daniele Donà; Amelia Romano; Icilio Dodi; Anna Maccabruni; Rita Consolini; Stefania Bernardi; Hyppolite Tchidjou Kuekou; Orazio Genovese; Paolina Olmeo; Letizia Cristiano; Antonio Mazza; Clara Gabiano; Silvia Garazzino; Antonio Pellegatta; D Pajkrt; Henriette Scherpbier; A Weijsenfeld; C. de Boer; S Jurriaans; N Back; H Zaaijer; B. Berkhout; M Cornelissen; C Schinkel; K Wolthers; P Fraaij; A van Rossum; L van Der Knaap; E Visser; M. Koopmans; J van Kampen; S Pas; S. Henriet; M van de Flier; K van Aerde; R Strik-Albers; J Rahamat-Langendoen; F Stelma; E Schölvinck; H de Groot-de Jonge; H Niesters; C van Leer-Buter; M Knoester; L Bont; S Geelen; T Wolfs; N Nauta; C Ang; R van Houdt; A Pettersson; C Vandenbroucke-Grauls; P. Reiss; D Bezemer; A van Sighem; Colette Smit; F Wit; T Boender; S Zaheri; M Hillebregt; A de Jong; D Bergsma; S Grivell; A Jansen; M Raethke; R Meijering; L de Groot; M van den Akker; Y Bakker; E Claessen; A El Berkaoui; J Koops; E Kruijne; C Lodewijk; L Munjishvili; B Peeck; C Ree; R Regtop; Y Ruijs; T Rutkens; M Schoorl; A Timmerman; E Tuijn; L Veenenberg; S van Der Vliet; A Wisse; T Woudstra; B Tuk; Jolanta Popielska; Maria Pokorska-Śpiewak; Agnieszka Ołdakowska; Konrad Zawadka; Urszula Coupland; Małgorzata Dorobalaura Marques; Carla Teixeira; Alexandre Fernandes; Filipa Prata; Luminita Ene; Liubov Okhonskaia; Evgeny Voronin; Milana Miloenko; Svetlana Labutina; José Tomás Ramos; Luis Prieto; Sara Guillén; María Luisa Navarro; Jesús Saavedra; Mar Santos; Mª Angeles Muñoz; Beatriz Ruiz; Carolina Fernandez Mc Phee; Santiago Jimenez de Ory; Susana Alvarez; Miguel Ángel Roa; José Beceiro; Jorge Martinez; Katie Badillo; Miren Apilanez; Itziar Pocheville; Elisa Garrote; Elena Colino; Jorge Gómez Sirvent; Mónica Garzón; Vicente Román; Abián Montesdeoca; Mercedes Mateo; María José Muñoz; Raquel Angulo; Olaf Neth; Lola Falcón; Pedro Terol; Juan J. Luis Santos; David Moreno; Francisco Lendínez; Ana Grande; Francisco José Romero; Miguel Lillo; Begoña Losada; Mercedes Herranz; Matilde Bustillo; Carmelo Guerrero; Pilar Collado; José Antonio Couceiro; Amparo Pérez; Ana Isabel Piqueras; Rafael Bretón; Inmaculada Segarra; César Gavilán; Enrique Jareño; Elena Montesinos; Marta Dapena; Cristina Álvarez; Ana Gloria Andrés; Víctor Marugán; Carlos Ochoa; Santiago Alfayate; Ana Isabel Menasalvas; Elisa de Miguel; K Aebi-Popp; S Asner; V. Aubert; M Battegay; M Baumann; E Bernasconi; J Böni; P Brazzola; H Bucher; A. Calmy; M Cavassini; A Ciuffi; A Duppenthaler; G Dollenmaier; M Egger; L Elzi; J Fehr; J Fellay; K Francini; H Furrer; C Fux; C Grawe; H Günthard; D Haerry; B Hasse; H Hirsch; M Hoffmann; I Hösli; C Kahlert; L. Kaiser; O Keiser; Thomas Klimkait; H Kovari; R Kouyos; B Ledergerber; G Martinetti; B Martinez de Tejada; K Metzner; N Müller; D Nicca; P Paioni; G Pantaleo; Ch Polli; K Posfay-Barbe; A Rauch; C Rudin; P Schmid; A Scherrer; R Speck; P Tarr; M Thanh Lecompte; A Trkola; P. Vernazza; N. Wagner; G Wandeler; R. Weber; C Wyler; S Yerly; Pornchai Techakunakorn; Rawiwan Hansudewechakul; Chiang Kham; Vanichaya Wanchaitanawong; Sookchai Theansavettrakul; Mae Sai; Sirisak Nanta; Chaiwat Ngampiyaskul; Siriluk Phanomcheong; Suchat Hongsiriwon; Warit Karnchanamayul; Ratchanee Kwanchaipanich; Suparat Kanjanavanit; Nareerat Kamonpakorn; Maneeratn Nantarukchaikul; Prapaisri Layangool; Jutarat Mekmullica; Paiboon Lucksanapisitkul; Sudarat Watanayothin; Narong Lertpienthum; Boonyarat Warachit; Sansanee Hanpinitsak; Sathit Potchalongsin; Pimpraphai Thanasiri; Sawitree Krikajornkitti; Pornsawan Attavinijtrakarn; Sakulrat Srirojana; Suthunya Bunjongpak; Achara Puangsombat; Sathaporn Na-Rajsima; Pornchai Ananpatharachai; Noppadon Akarathum; Vachira Phuket; Weerasak Lawtongkum; Prapawan Kheunjan; Thitiporn Suriyaboon; Airada Saipanya; Kanchana Than-In-At; Nirattiya Jaisieng; Rapeepan Suaysod; Sanuphong Chailoet; Naritsara Naratee; Suttipong Kawilapat; T Kaleeva; Y Baryshnikova; S Soloha; N Bashkatova; I Raus; O Glutshenko; Z Ruban; N Prymak; Galyna Kiseleva; H Bailey; Alasdair Bamford; Conor Doherty; Caroline Foster; Kate Francis; Ian Harrison; Julia Kenny; Gillian Letting; Fungai Murau; Edith Nsangi; Anna Turkova; Claire Cook; Siobhan Crichton; Donna Dobson; Keith Fairbrother; Diana M Gibb; Lynda Harper; Marthe Le Prevost; Nadine van Looy; Helen Peters; Karina Butler; A. Walsh; L Thrasyvoulou; Steve Welch; J Bernatoniene; F Manyika; G Sharpe; B Subramaniam; K Sloper; K Fidler; R Hague; V Price; M Clapson; J Flynn; A Cardoso; M Abou-Rayyah; Nigel Klein; Delane Shingadia; D Gurtin; S Yeadon; S Segalc Ball; S Hawkins; M Dowie; S Bandi; E Percival; M Eisenhut; K Duncan; S Clough; L Anguvaa; S. Conway; T Flood; A Pickering; C Murphy; J. E. Daniels; Y Lees; F Thompson; B. Williams; S Pope; L Cliffe; A Smyth; S Southall; A. Freeman; H Freeman; S Christie; A Gordon; D Rogahn; L Clarke; L Jones; B Offerman; M Greenberg; C Benson; Andrew Riordan; L Ibberson; Fiona Shackley; S Faust; J Hancock; Katja Doerholt; Katia Prime; M. Sharland; Sharon Storey; H Lyall; C Monrose; P Seery; Gareth Tudor-Williams; E Menson; A Callaghan; A Bridgwood; Paddy Mcmaster; J. Evans; E Blake; A Yannoulias; Elizabeth Chappell; Siobhan Critchton; Intira Jeannie Collins; Charlotte Duff; Carlo Giaquinto; Ruth Goodall; Daniel Gomezpena; Ali Judd; Rebecca Lundin; Laura Mangiarini; Alessandra Nardone; Claire Thorne

doi:10.1093/cid/ciz253

Back

Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study *

Journal article

Open access

Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study *

Gonzague Jourdain, Antoni Soriano-Arandes, Intira Collins, Laura Marqués, Elena Chiappini, Luisa Galli, Lars Naver, Diana Gibb, Magdalena Marczynska, Marc Lallemant, …

Clinical Infectious Diseases, Vol.70(3), pp.404-415

28/03/2019

DOI: https://doi.org/10.1093/cid/ciz253

PMID: 30919882

Abstract

HIV

antiretroviral therapy

children

poor immune response

viral suppression

In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART.

Files and links (2)

url

Find in HALView

url

https://doi.org/10.1093/cid/ciz253View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with human immunodeficiency virus in Europe and Thailand: cohort study *
Creators - without role: Gonzague Jourdain
Antoni Soriano-Arandes
Intira Collins - UK Centre for Ecology & Hydrology
Laura Marqués - Universidad de Alcalá
Elena Chiappini - University of Florence
Luisa Galli - University of Florence
Lars Naver
Diana Gibb
Magdalena Marczynska
Marc Lallemant - Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est
Nicole Ngo-Giang-Huong - Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est
Ruslan Malyuta
Alla Volokha
Tessa Goetghebuer
Marc Hainaut
Marc Delforge
Josiane Warszawski - Centre de recherche en Epidémiologie et Santé des Populations
Jérôme Le Chenadec - Centre de recherche en Epidémiologie et Santé des Populations
Elisa Ramos
Olivia Dialla - Centre de recherche en Epidémiologie et Santé des Populations
Thierry Wack - Centre de recherche en Epidémiologie et Santé des Populations
Corine Laurent
Lamya Ait Si Selmi
Isabelle Leymarie
Fazia Ait Benali
Maud Brossard
Leila Boufassa
Corinne Floch-Tudal
Ghislaine Firtion
Isabelle Hau
Anne Chace
Pascal Bolot - Centre Hospitalier Saint-Denis
Stephane Blanche - Hôpital Necker-Enfants Malades
Martine Levine
Le Kremlin Bicëtre
Corinne Fourcade
Brigitte Heller-Roussin
Camille Runel-Belliard
Joëlle Tricoire
Catherine Chirouze - Centre Hospitalier Universitaire de Besançon
Véronique Reliquet - Service des maladies infectieuses et tropicales [CHU Nantes]
Jacques Brouard - Centre Hospitalier Universitaire de Caen
Kamila Kebaili - Institut d’Hématologie et d’Oncologie Pédiatrique
Pascale Fialaire
Muriel Lalande - Centre Hospitalier Universitaire de Montpellier
Stephan Schultze-Strasser - University Hospital Frankfurt
U Baumann
T Niehues
J Neubert
R Kobbe
Charite Berlin
C Feiterna-Sperling
Christoph Königs - Goethe University Frankfurt
B Buchholz
G Notheis
Vana Spoulou
Maurizio de Martino - University of Florence
Pier Angelo Tovo
Osimani Patrizia
Domenico Larovere
Maurizio Ruggeri
Giacomo Faldella
Francesco Baldi
Raffaele Badolato
Carlotta Montagnani
Elisabetta Venturini
Catiuscia Lisi
Antonio Di Biagio - Infectious Diseases
Lucia Taramasso - Infectious Diseases
Vania Giacomet
Paola Erba
Susanna Esposito - Department of Maternal and Pediatric Sciences
Rita Lipreri
Filippo Salvini
Claudia Tagliabue
Monica Cellini
Eugenia Bruzzese
Andrea Lo Vecchio
Osvalda Rampon
Daniele Donà
Amelia Romano
Icilio Dodi - Maternal-Infantile Department, Unit of Paediatrics and Oncohematology
Anna Maccabruni - University of Pavia
Rita Consolini
Stefania Bernardi
Hyppolite Tchidjou Kuekou
Orazio Genovese - Department of Paediatrics
Paolina Olmeo
Letizia Cristiano
Antonio Mazza - Dipartimento di Ingegneria [Benevento]
Clara Gabiano
Silvia Garazzino
Antonio Pellegatta
D Pajkrt
Henriette Scherpbier
A Weijsenfeld
C. de Boer - University of Twente
S Jurriaans
N Back
H Zaaijer
B. Berkhout - Université de Montpellier, Institut de Génétique Humaine - IGH
M Cornelissen
C Schinkel
K Wolthers
P Fraaij
A van Rossum
L van Der Knaap
E Visser
M. Koopmans - Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control
J van Kampen
S Pas
S. Henriet - Architecture et Réactivité de l'arN
M van de Flier
K van Aerde
R Strik-Albers
J Rahamat-Langendoen
F Stelma
E Schölvinck
H de Groot-de Jonge
H Niesters
C van Leer-Buter
M Knoester
L Bont
S Geelen
T Wolfs
N Nauta
C Ang
R van Houdt
A Pettersson
C Vandenbroucke-Grauls
P. Reiss - CEA Grenoble
D Bezemer
A van Sighem
Colette Smit - Stichting HIV Monitoring
F Wit
T Boender
S Zaheri
M Hillebregt
A de Jong
D Bergsma
S Grivell
A Jansen
M Raethke
R Meijering
L de Groot
M van den Akker
Y Bakker
E Claessen
A El Berkaoui
J Koops
E Kruijne
C Lodewijk
L Munjishvili
B Peeck
C Ree
R Regtop
Y Ruijs
T Rutkens
M Schoorl
A Timmerman
E Tuijn
L Veenenberg
S van Der Vliet
A Wisse
T Woudstra
B Tuk
Jolanta Popielska
Maria Pokorska-Śpiewak
Agnieszka Ołdakowska
Konrad Zawadka
Urszula Coupland
Małgorzata Dorobalaura Marques
Carla Teixeira
Alexandre Fernandes - Universidade Federal do Ceará
Filipa Prata
Luminita Ene
Liubov Okhonskaia
Evgeny Voronin
Milana Miloenko
Svetlana Labutina
José Tomás Ramos
Luis Prieto
Sara Guillén
María Luisa Navarro
Jesús Saavedra
Mar Santos
Mª Angeles Muñoz
Beatriz Ruiz
Carolina Fernandez Mc Phee
Santiago Jimenez de Ory
Susana Alvarez - Universidade de Vigo
Miguel Ángel Roa
José Beceiro
Jorge Martinez - Universitat Politècnica de València
Katie Badillo
Miren Apilanez
Itziar Pocheville
Elisa Garrote
Elena Colino
Jorge Gómez Sirvent
Mónica Garzón
Vicente Román
Abián Montesdeoca
Mercedes Mateo
María José Muñoz
Raquel Angulo
Olaf Neth
Lola Falcón
Pedro Terol
Juan J. Luis Santos - Fac Biol, Dept Genet
David Moreno
Francisco Lendínez
Ana Grande
Francisco José Romero
Miguel Lillo
Begoña Losada - University of the Basque Country
Mercedes Herranz
Matilde Bustillo
Carmelo Guerrero
Pilar Collado
José Antonio Couceiro
Amparo Pérez
Ana Isabel Piqueras
Rafael Bretón
Inmaculada Segarra
César Gavilán
Enrique Jareño
Elena Montesinos
Marta Dapena
Cristina Álvarez
Ana Gloria Andrés
Víctor Marugán
Carlos Ochoa
Santiago Alfayate
Ana Isabel Menasalvas
Elisa de Miguel
K Aebi-Popp
S Asner
V. Aubert
M Battegay
M Baumann
E Bernasconi
J Böni
P Brazzola
H Bucher
A. Calmy - Service des maladies infectieuses
M Cavassini
A Ciuffi
A Duppenthaler
G Dollenmaier
M Egger
L Elzi
J Fehr
J Fellay
K Francini
H Furrer
C Fux
C Grawe
H Günthard
D Haerry
B Hasse
H Hirsch
M Hoffmann
I Hösli
C Kahlert
L. Kaiser
O Keiser
Thomas Klimkait - University of Basel
H Kovari
R Kouyos
B Ledergerber
G Martinetti
B Martinez de Tejada
K Metzner
N Müller
D Nicca
P Paioni
G Pantaleo
Ch Polli
K Posfay-Barbe
A Rauch
C Rudin
P Schmid
A Scherrer
R Speck
P Tarr
M Thanh Lecompte
A Trkola
P. Vernazza
N. Wagner - Dysfonctions métaboliques et diabètes: Mécanismes et approches thérapeutiques
G Wandeler
R. Weber - Universitäts-Herzzentrum Freiburg-Bad Krozingen
C Wyler
S Yerly
Pornchai Techakunakorn
Rawiwan Hansudewechakul
Chiang Kham
Vanichaya Wanchaitanawong
Sookchai Theansavettrakul
Mae Sai
Sirisak Nanta
Chaiwat Ngampiyaskul - Prapokklao Hospital
Siriluk Phanomcheong
Suchat Hongsiriwon
Warit Karnchanamayul
Ratchanee Kwanchaipanich
Suparat Kanjanavanit - Nakornping Hospital
Nareerat Kamonpakorn
Maneeratn Nantarukchaikul
Prapaisri Layangool
Jutarat Mekmullica
Paiboon Lucksanapisitkul
Sudarat Watanayothin
Narong Lertpienthum
Boonyarat Warachit
Sansanee Hanpinitsak
Sathit Potchalongsin
Pimpraphai Thanasiri
Sawitree Krikajornkitti - Samutsakhon Hospital [Samutsakhon, Thailand]
Pornsawan Attavinijtrakarn
Sakulrat Srirojana - Kalasin University
Suthunya Bunjongpak
Achara Puangsombat
Sathaporn Na-Rajsima
Pornchai Ananpatharachai
Noppadon Akarathum - SanPaTong Hospital
Vachira Phuket
Weerasak Lawtongkum
Prapawan Kheunjan
Thitiporn Suriyaboon
Airada Saipanya
Kanchana Than-In-At
Nirattiya Jaisieng
Rapeepan Suaysod
Sanuphong Chailoet
Naritsara Naratee
Suttipong Kawilapat - Chiang Mai University
T Kaleeva
Y Baryshnikova
S Soloha
N Bashkatova
I Raus
O Glutshenko
Z Ruban
N Prymak
Galyna Kiseleva
H Bailey
Alasdair Bamford
Conor Doherty
Caroline Foster
Kate Francis
Ian Harrison
Julia Kenny
Gillian Letting
Fungai Murau
Edith Nsangi
Anna Turkova
Claire Cook
Siobhan Crichton
Donna Dobson
Keith Fairbrother
Diana M Gibb
Lynda Harper
Marthe Le Prevost
Nadine van Looy
Helen Peters
Karina Butler
A. Walsh - Microbiology Department
L Thrasyvoulou
Steve Welch - University of Edinburgh
J Bernatoniene
F Manyika
G Sharpe
B Subramaniam
K Sloper
K Fidler
R Hague
V Price
M Clapson
J Flynn
A Cardoso
M Abou-Rayyah
Nigel Klein - Infectious Diseases and Microbiology Unit
Delane Shingadia
D Gurtin
S Yeadon
S Segalc Ball
S Hawkins
M Dowie
S Bandi
E Percival
M Eisenhut
K Duncan
S Clough
L Anguvaa
S. Conway
T Flood
A Pickering
C Murphy
J. E. Daniels - European Synchrotron Radiation Facility
Y Lees
F Thompson
B. Williams - Centre for Ecology and Hydrology [Bangor]
S Pope
L Cliffe
A Smyth
S Southall
A. Freeman - Jet Propulsion Laboratory
H Freeman
S Christie
A Gordon
D Rogahn
L Clarke
L Jones
B Offerman
M Greenberg
C Benson
Andrew Riordan
L Ibberson
Fiona Shackley
S Faust
J Hancock
Katja Doerholt
Katia Prime
M. Sharland - University College London
Sharon Storey
H Lyall
C Monrose
P Seery
Gareth Tudor-Williams
E Menson
A Callaghan
A Bridgwood
Paddy Mcmaster
J. Evans - London South Bank University
E Blake
A Yannoulias
Elizabeth Chappell
Siobhan Critchton
Intira Jeannie Collins
Charlotte Duff
Carlo Giaquinto - University of Padua
Ruth Goodall
Daniel Gomezpena
Ali Judd
Rebecca Lundin
Laura Mangiarini
Alessandra Nardone
Claire Thorne - Université Grenoble Alpes
Publication Details: Clinical Infectious Diseases, Vol.70(3), pp.404-415
Identifiers: 9933810209311
Academic Unit: Institut de Génétique Humaine - IGH
Language: English
Resource Type: Journal article
Local Fields: hal-02549056