Predicting the Long-Term Course of Asthma in Wheezing Infants Is Still a Challenge

Flore Amat; Amandine Vial; Bruno Pereira; Isabelle Petit; André Labbe; Jocelyne Just

doi:10.5402/2011/493624

Retour

Predicting the Long-Term Course of Asthma in Wheezing Infants Is Still a Challenge

Article de revue

Avec comité de lecture

Predicting the Long-Term Course of Asthma in Wheezing Infants Is Still a Challenge

Flore Amat, Amandine Vial, Bruno Pereira, Isabelle Petit, André Labbe et Jocelyne Just

ISRN allergy, Vol.2011(2011), pp.1-5

2011

DOI: https://doi.org/10.5402/2011/493624

PMID: 23724229

Résumé

Clinical Study

Background. In recurrent wheezing infants, it is important to identify those likely to remain asthmatic in order to propose appropriate long-term management. Objective. To establish predictive factors for persistent asthma at adolescence in a population of recurrent wheezing infants. Methods. Retrospective study of 227 infants. Inclusion criteria were age under 36 months, a history of at least three wheezing episodes assessed via a doctor-led ISAAC questionnaire and a standardized allergy testing programme. At 13 years, active asthma was assessed by questionnaire. Results. Risk factors for asthma persisting into adolescence were allergic sensitization to multiple airborne allergens (OR 4.6, CI-95% (1.9–11.2) P = 0.001), initial atopic dermatitis (OR 3.4, CI-95% (1.9–6.3) P < 0.001), severe recurrent wheezing (OR 2.3, CI-95% (1.3–4.2) P = 0.007), and hypereosinophilia ≥470/mm3 (OR 2.2, CI-95% (1.07–4.7) P = 0.033). Conclusion. While it is still difficult to predict the long-term course of asthma, atopy remains the major risk factor for persistent asthma.

Indicateurs

1 Consultations de la notice

Détails

Titre: Predicting the Long-Term Course of Asthma in Wheezing Infants Is Still a Challenge
Créateurs - sans rôle: Flore Amat - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
Amandine Vial - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
Bruno Pereira - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
Isabelle Petit - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
André Labbe - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
Jocelyne Just - Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France
Détails de publication: ISRN allergy, Vol.2011(2011), pp.1-5
Éditeur: International Scholarly Research Network
Identifiants: 99150135909311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article