Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

Ivana Acimovic; Marwan Refaat; Adrien Moreau; Anton Salykin; Steve Reiken; Yvonne Sleiman; Monia Souidi; Jan Přibyl; Andrey Kajava; Sylvain Richard; Jonathan Lu; Philippe Chevalier; Petr Skladal; Petr Dvořak; Vladimir Rotrekl; Andrew Marks; Melvin Scheinman; Alain Lacampagne; Albano C Meli

doi:10.3390/jcm7110423

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Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

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Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

Ivana Acimovic, Marwan Refaat, Adrien Moreau, Anton Salykin, Steve Reiken, Yvonne Sleiman, Monia Souidi, Jan Přibyl, Andrey Kajava, Sylvain Richard, …

Journal of Clinical Medicine Research, Vol.7(11)

2018

DOI: https://doi.org/10.3390/jcm7110423

PMID: 30413023

Abstract

calcium

flecainide

hiPSC-derived cardiomyocytes

post-translational modifications

ryanodine receptor

β-adrenergic receptor blockade

CPVT

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Title: Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes
Creators - without role: Ivana Acimovic - Masaryk University
Marwan Refaat - American University of Beirut
Adrien Moreau - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Anton Salykin - Masaryk University
Steve Reiken - Columbia University
Yvonne Sleiman - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Monia Souidi - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Jan Přibyl - Masaryk University
Andrey Kajava - Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Sylvain Richard - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Jonathan Lu - Columbia University
Philippe Chevalier - Institut NeuroMyoGène
Petr Skladal - Masaryk University
Petr Dvořak - Masaryk University
Vladimir Rotrekl - Masaryk University
Andrew Marks - Columbia University
Melvin Scheinman - University of California, San Francisco
Alain Lacampagne - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Albano C Meli - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Publication Details: Journal of Clinical Medicine Research, Vol.7(11)
Identifiers: 9935171009311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp; Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Language: English
Resource Type: Journal article
Local Fields: hal-01918447