Population genomics reveals the origin and asexual evolution of human infective trypanosomes

William Weir; Paul Capewell; Bernardo Foth; Caroline Clucas; Andrew Pountain; Pieter Steketee; Nicola Veitch; Mathurin Koffi; Thierry De Meeûs; Jacques Kaboré; Mamadou Camara; Anneli Cooper; Andy Tait; Vincent Jamonneau; Bruno Bucheton; Matt Berriman; Annette MacLeod

doi:10.7554/eLife.11473

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Population genomics reveals the origin and asexual evolution of human infective trypanosomes

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Population genomics reveals the origin and asexual evolution of human infective trypanosomes

William Weir, Paul Capewell, Bernardo Foth, Caroline Clucas, Andrew Pountain, Pieter Steketee, Nicola Veitch, Mathurin Koffi, Thierry De Meeûs, Jacques Kaboré, …

eLife, Vol.5(2016), pp.e11473-e11473

26/01/2016

DOI: https://doi.org/10.7554/eLife.11473

PMID: 26809473

Résumé

Evolution, Molecular

Humans

Metagenomics

Mutation

Reproduction, Asexual

Trypanosoma brucei gambiense - genetics

Trypanosomiasis - parasitology

Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving independently of each other, a phenomenon termed the Meselson effect. We apply a population genomics approach to examine this effect in an important human pathogen, Trypanosoma brucei gambiense. We determine that T.b. gambiense is evolving strictly asexually and is derived from a single progenitor, which emerged within the last 10,000 years. We demonstrate the Meselson effect for the first time at the genome-wide level in any organism and show large regions of loss of heterozygosity, which we hypothesise to be a short-term compensatory mechanism for counteracting deleterious mutations. Our study sheds new light on the genomic and evolutionary consequences of strict asexuality, which this pathogen uses as it exploits a new biological niche, the human population.

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Titre: Population genomics reveals the origin and asexual evolution of human infective trypanosomes
Créateurs - sans rôle: William Weir - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Paul Capewell - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Bernardo Foth - Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
Caroline Clucas - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Andrew Pountain - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Pieter Steketee - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Nicola Veitch - West Medical Building, Office 350, University of Glasgow, Glasgow, Scotland
Mathurin Koffi - Université Jean Lorougnon Guédé
Thierry De Meeûs - Centre International de Recherche-Développement de l'Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso
Jacques Kaboré - Université Polytechnique de Bobo-Dioulasso, UFR Sciences et Techniques, Bobo-Dioulasso, Burkina Faso
Mamadou Camara - Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Conakry, Guinea
Anneli Cooper - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Andy Tait - Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Vincent Jamonneau - Centre International de Recherche-Développement de l'Elevage en zone Subhumide, Bobo-Dioulasso, Burkina Faso
Bruno Bucheton - Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Conakry, Guinea
Matt Berriman - Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
Annette MacLeod - University of Glasgow
Détails de publication: eLife, Vol.5(2016), pp.e11473-e11473
Identifiants: 99140091309311
Unité académique: Intéractions hôtes-vecteurs-parasites-environnement maladies tropicales - INTERTRYP
Langue: English
Type de ressource: Journal article