Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

Andrea Mascitti; Massimiliano Lupacchini; Ruben Guerra; Ilya Taydakov; Lucia Tonucci; Nicola D’alessandro; Frédéric Lamaty; Jean Martinez; Evelina Colacino

doi:10.3762/bjoc.13.3

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Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

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Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

Andrea Mascitti, Massimiliano Lupacchini, Ruben Guerra, Ilya Taydakov, Lucia Tonucci, Nicola D’alessandro, Frédéric Lamaty, Jean Martinez et Evelina Colacino

Beilstein Journal of Organic Chemistry, Vol.13, pp.19 - 25

04/01/2017

DOI: https://doi.org/10.3762/bjoc.13.3

Résumé

poly(ethylene) glycols (PEGs)

liquid-assisted grinding (LAG)

mechanochemistry

hydantoins

1'-carbonyldiimidazole (CDI)

ball-milling

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under drygrinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.

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Titre: Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
Créateurs - sans rôle: Andrea Mascitti - Centre National de la Recherche Scientifique
Massimiliano Lupacchini - École Nationale Supérieure de Chimie de Montpellier
Ruben Guerra
Ilya Taydakov - P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Lucia Tonucci - University of Chieti-Pescara
Nicola D’alessandro - University of Chieti-Pescara
Frédéric Lamaty - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Jean Martinez - Institut des Biomolécules Max Mousseron
Evelina Colacino - Institut des Biomolécules Max Mousseron
Détails de publication: Beilstein Journal of Organic Chemistry, Vol.13, pp.19 - 25
Identifiants: 99153374609311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03079220