Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17

Coline Ple; Ying Fan; Saliha Ait Yahia; Han Vorng; Laetitia Everaere; Cécile Chenivesse; Joanne Balsamelli; Imane Azzaoui; Patricia De Nadai; Benoit Wallaert; Gwendal Lazennec; Anne Tsicopoulos

doi:10.1371/journal.pone.0122372

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Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17

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Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17

Coline Ple, Ying Fan, Saliha Ait Yahia, Han Vorng, Laetitia Everaere, Cécile Chenivesse, Joanne Balsamelli, Imane Azzaoui, Patricia De Nadai, Benoit Wallaert, …

PLoS ONE, Vol.10(4)

10/04/2015

DOI: https://doi.org/10.1371/journal.pone.0122372

PMCID: PMC4393221

PMID: 25860963

Abstract

Adult

Asthma

Benzo(a)pyrene

Receptors, Aryl Hydrocarbon

Cells, Cultured

Th17 Cells

Up-Regulation

Vehicle Emissions

CD4-Positive T-Lymphocytes

Cytochrome P-450 CYP1A1

Interleukins

Down-Regulation

Leukocytes, Mononuclear

Female

Humans

Interleukin-17

JNK Mitogen-Activated Protein Kinases

Male

Polycyclic Aromatic Hydrocarbons

Middle Aged

Nuclear Receptor Subfamily 1, Group F, Member 1

Nuclear Receptor Subfamily 1, Group F, Member 3

Phosphatidylinositol 3-Kinases

RNA, Messenger

Background: Pollution, including polyaromatic hydrocarbons (PAH), may contribute to increased

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Title: Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17
Creators - without role: Coline Ple - Université Lille Nord de France
Ying Fan - Université de Lille
Saliha Ait Yahia - Université Lille Nord de France
Han Vorng - Université de Lille
Laetitia Everaere - Center for Infection and Immunity of Lille
Cécile Chenivesse - Center for Infection and Immunity of Lille
Joanne Balsamelli - Center for Infection and Immunity of Lille
Imane Azzaoui - Center for Infection and Immunity of Lille
Patricia De Nadai
Benoit Wallaert - Université de Lille
Gwendal Lazennec - Centre National de la Recherche Scientifique
Anne Tsicopoulos - Centre National de la Recherche Scientifique
Publication Details: PLoS ONE, Vol.10(4)
Identifiers: 9946833709311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Language: English
Resource Type: Journal article
Local Fields: hal-03002029