Résumé
Fundamental transformations in organic synthesis, such as the Wittig, Staudinger, Appel and Mitsunobu reactions, have traditionally relied on stoichiometric amounts of phosphine, leading to phosphine oxide by-products. Due to their high stability and polarity, these oxides complicate purification processes and diminish overall reaction efficiency. In 2015, members of the American Chemical Society emphasized the need to develop methodologies that minimize or eliminate phosphine oxide waste. This call to action has since spurred widespread innovation and driven numerous research groups to reassess their synthetic approaches. This review highlights recent advances over the past two decades in phosphorus-based redox organocatalysis, which represent a promising direction for expanding the scope and sustainability of phosphorus-mediated transformations.
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