Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

Behnood Bikdeli; Mahesh Madhavan; Aakriti Gupta; David Jimenez; John Burton; Caroline Der Nigoghossian; Taylor Chuich; Shayan Nabavi Nouri; Isaac Dreyfus; Elissa Driggin; Sanjum Sethi; Kartik Sehgal; Saurav Chatterjee; Walter Ageno; Mohammad Madjid; Yutao Guo; Liang Tang; Yu Hu; Laurent Bertoletti; Jay Giri; Mary Cushman; Isabelle Quéré; Evangelos Dimakakos; C Michael Gibson; Giuseppe Lippi; Emmanuel Favaloro; Jawed Fareed; Alfonso Tafur; Dominic Francese; Jaya Batra; Anna Falanga; Kevin Clerkin; Nir Uriel; Ajay Kirtane; Claire Mclintock; Beverley Hunt; Alex Spyropoulos; Geoffrey Barnes; John Eikelboom; Ido Weinberg; Sam Schulman; Marc Carrier; Gregory Piazza; Joshua Beckman; Martin Leon; Gregg Stone; Stephan Rosenkranz; Samuel Goldhaber; Sahil Parikh; Manuel Monreal; Harlan Krumholz; Stavros Konstantinides; Jeffrey Weitz; Gregory Lip; The Global COVID-19 Thrombosis Collaborative Group

doi:10.1055/s-0040-1713152

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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

Behnood Bikdeli, Mahesh Madhavan, Aakriti Gupta, David Jimenez, John Burton, Caroline Der Nigoghossian, Taylor Chuich, Shayan Nabavi Nouri, Isaac Dreyfus, Elissa Driggin, …

Thrombosis and haemostasis, Vol.120(7), pp.1004-1024

01/07/2020

DOI: https://doi.org/10.1055/s-0040-1713152

PMID: 32473596

Résumé

Animals

Anti-Inflammatory Agents

Anticoagulants

Antiviral Agents

Betacoronavirus

Coronavirus Infections

COVID-19

Emerging diseases

Fibrinolytic Agents

Glycosaminoglycans

Hemostasis

Human health and pathology

Humans

Infectious diseases

Inflammation

Life Sciences

Pandemics

Platelet Aggregation Inhibitors

Pneumonia, Viral

Santé publique et épidémiologie

SARS-CoV-2

Thrombosis

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct antithrombotic effects, other mechanisms of action, including anti-inflammatory or antiviral effects, have been postulated. Based on survey results from this group of authors, we suggest research priorities for specific agents and subgroups of patients with COVID-19. Further, we review other agents, including immunomodulators, that may have antithrombotic properties. It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.

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Détails

Titre: Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
Créateurs - sans rôle: Behnood Bikdeli - New York Presbyterian Hospital
Mahesh Madhavan - New York Presbyterian Hospital
Aakriti Gupta - New York Presbyterian Hospital
David Jimenez - Hospital Universitario Ramón y Cajal [Madrid]
John Burton - New York Presbyterian Hospital
Caroline Der Nigoghossian - New York Presbyterian Hospital
Taylor Chuich - New York Presbyterian Hospital
Shayan Nabavi Nouri - New York Presbyterian Hospital
Isaac Dreyfus - New York Presbyterian Hospital
Elissa Driggin - New York Presbyterian Hospital
Sanjum Sethi - New York Presbyterian Hospital
Kartik Sehgal - Beth Israel Deaconess Medical Center [Boston]
Saurav Chatterjee - North Shore University Hospital and Long Island Jewish Medical Center & The Feinstein Institute for Medical Research
Walter Ageno - University of Insubria
Mohammad Madjid - McGovern Medical School [Houston, Texas]
Yutao Guo - Chinese PLA General Hospital
Liang Tang - Tongji Medical College [HUST]
Yu Hu - Tongji Medical College [HUST]
Laurent Bertoletti - Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
Jay Giri - Hospital of the University of Pennsylvania
Mary Cushman - Larner College of Medicine [University of Vermont, Burlington]
Isabelle Quéré - Centre Hospitalier Régional Universitaire [Montpellier]
Evangelos Dimakakos - Sotiria Thoracic Diseases Hospital of Athens
C Michael Gibson - Harvard Medical School
Giuseppe Lippi - University Hospital of Verona
Emmanuel Favaloro - Westmead Hospital
Jawed Fareed - Loyola University Medical Center
Alfonso Tafur - The Pritzker School of Medicine
Dominic Francese - Cardiovascular Research Foundation
Jaya Batra - New York Presbyterian Hospital
Anna Falanga - Hospital Papa Giovanni XXIII
Kevin Clerkin - New York Presbyterian Hospital
Nir Uriel - New York Presbyterian Hospital
Ajay Kirtane - New York Presbyterian Hospital
Claire Mclintock - Auckland City Hospital
Beverley Hunt - Guy's and St Thomas' Hospital [London]
Alex Spyropoulos - Donald and Barbara Zucker School of Medicine at Hofstra/Northwell [Hempstead, NY, USA]
Geoffrey Barnes - University of Michigan
John Eikelboom - McMaster University
Ido Weinberg - Harvard Medical School
Sam Schulman - Sechenov First Moscow State Medical University
Marc Carrier - Brigham & Women’s Hospital [Boston]
Gregory Piazza - Harvard Medical School
Joshua Beckman - Vanderbilt University School of Medicine
Martin Leon - New York Presbyterian Hospital
Gregg Stone - Cardiovascular Research Foundation
Stephan Rosenkranz - University Hospital Cologne
Samuel Goldhaber - Harvard Medical School
Sahil Parikh - New York Presbyterian Hospital
Manuel Monreal - Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute
Harlan Krumholz - Yale School of Medicine
Stavros Konstantinides - University Medical Center of the Johannes Gutenberg University Mainz
Jeffrey Weitz - McMaster University
Gregory Lip - Liverpool Heart & Chest Hospital
The Global COVID-19 Thrombosis Collaborative Group
Détails de publication: Thrombosis and haemostasis, Vol.120(7), pp.1004-1024
Éditeur: Schattauer
Nombre de pages: 21
Identifiants: 99139063209311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article