Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

Jeffrey Milbrandt; Frederic J de Sauvage; Timothy J Fahrner; Robert H Baloh; Melanie L Leitner; Malú G Tansey; Patricia A Lampe; Robert O Heuckeroth; Paul T Kotzbauer; Kelli S Simburger; Judith P Golden; Jamie A Davies; Richard Vejsada; Ann C Kato; Mary Hynes; Daniel Sherman; Merry Nishimura; Li-Chong Wang; Richard Vandlen; Barbara Moffat; Robert D Klein; Kris Poulsen; Christa Gray; Alain Garces; Christopher E Henderson; Heidi S Phillips; Eugene M Johnson

doi:10.1016/S0896-6273(00)80453-5

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Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

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Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

Jeffrey Milbrandt, Frederic J de Sauvage, Timothy J Fahrner, Robert H Baloh, Melanie L Leitner, Malú G Tansey, Patricia A Lampe, Robert O Heuckeroth, Paul T Kotzbauer, Kelli S Simburger, …

Neuron (Cambridge, Mass.), Vol.20(2), pp.245-253

01/02/1998

DOI: https://doi.org/10.1016/S0896-6273(00)80453-5

PMID: 9491986

Résumé

A novel neurotrophic factor named Persephin that is ∼40% identical to glial cell line–derived neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR. Persephin, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. Persephin also supports the survival of motor neurons in culture and in vivo after sciatic nerve axotomy and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and NTN, persephin does not support any of the peripheral neurons that were examined. Fibroblasts transfected with Ret and one of the coreceptors GFRα-1 or GFRα-2 do not respond to persephin, suggesting that persephin utilizes additional, or different, receptor components than GDNF and NTN.

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Détails

Titre: Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin
Créateurs - sans rôle: Jeffrey Milbrandt - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Frederic J de Sauvage - Genentech, South San Francisco, California 94080, USA
Timothy J Fahrner - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Robert H Baloh - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Melanie L Leitner - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Malú G Tansey - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Patricia A Lampe - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Robert O Heuckeroth - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Paul T Kotzbauer - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Kelli S Simburger - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Judith P Golden - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Jamie A Davies - University of Edinburgh Medical School, Edinburgh, EH8 9AG, United Kingdom
Richard Vejsada - Geneva University Medical School, CH-1211 Geneva 4, Switzerland
Ann C Kato - Geneva University Medical School, CH-1211 Geneva 4, Switzerland
Mary Hynes - Genentech, South San Francisco, California 94080, USA
Daniel Sherman - Genentech, South San Francisco, California 94080, USA
Merry Nishimura - Genentech, South San Francisco, California 94080, USA
Li-Chong Wang - Genentech, South San Francisco, California 94080, USA
Richard Vandlen - Genentech, South San Francisco, California 94080, USA
Barbara Moffat - Genentech, South San Francisco, California 94080, USA
Robert D Klein - Genentech, South San Francisco, California 94080, USA
Kris Poulsen - Genentech, South San Francisco, California 94080, USA
Christa Gray - Genentech, South San Francisco, California 94080, USA
Alain Garces - Inserm
Christopher E Henderson - INSERM U.382 IBDM (INSERM-CNRS-Univ. Mediterranee)Marseille 09, France
Heidi S Phillips - Genentech, South San Francisco, California 94080, USA
Eugene M Johnson - Washington University School of Medicine, St. Louis, Missouri 63110, USA
Détails de publication: Neuron (Cambridge, Mass.), Vol.20(2), pp.245-253
Éditeur: Elsevier Inc
Nombre de pages: 9
Identifiants: 99155014209311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article