Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015

J. Bousquet; J.M. Anto; M. Akdis; C. Auffray; T. Keil; I. Momas; D.S. Postma; R. Valenta; M. Wickman; A. Cambon-Thomsen; T. Haahtela; B.N. Lambrecht; K. C. Lodrup Carlsen; G.H. Koppelman; J. Sunyer; T. Zuberbier; Isabella Annesi-Maesano; A. Arno; C. Bindslev-Jensen; G. de Carlo; F. Forastiere; J. Heinrich; M. Kowalski; D. Maier; E. Melén; S. Palkonen; H.A. Smit; M. Standl; J. Wright; A. Asarnoj; M. Benet; N. Ballardini; J. Garcia-Aymerich; U. Gehring; S. Guerra; C. Hohman; I. Kull; C. Lupinek; M. Pinart; I. Skrindo; M. Westman; D. Smagghe; C. Akdis; R. Albang; V. Anastasova; N. Anderson; C. Bachert; S. Ballereau; F. Ballester; X. Basagaña; A. Bedbrook; A. Bergstrom; A. von Berg; B. Brunekreef; E. Burte; K. Carlsen; L. Chatzi; J.M. Coquet; M. Curin; P. Demoly; E. Eller; M.P. Fantini; B. Gerhard; H. Hammad; L. von Hertzen; V. Hovland; B. Jacquemin; J. Just; T. Keller; M. Kerkhof; R. Kiss; M. Kogevinas; S. Koletzko; S. Lau; I. Lehmann; N. Lemonnier; R. Mceachan; M. Mäkelä; J. Mestres; E. Minina; P. Mowinckel; R. Nadif; M. Nawijn; S. Oddie; J. Pellet; I. Pin; D. Porta; F. Rancière; A. Rial-Sebbag; Y. Saeys; M.J. Schuijs; V. Siroux; C.G. Tischer; M. Torrent; R. Varraso; J. de Vocht; K. Wenger; S. Wieser; C. Xu

doi:10.1111/all.12880

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Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015

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Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015

J. Bousquet, J.M. Anto, M. Akdis, C. Auffray, T. Keil, I. Momas, D.S. Postma, R. Valenta, M. Wickman, A. Cambon-Thomsen, …

Allergy, Vol.71(11), pp.1513 - 1525

2016

DOI: https://doi.org/10.1111/all.12880

PMCID: PMC5248602

PMID: 26970340

Abstract

IgE

asthma

multimorbidity

polysensitization

rhinitis

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

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Title: Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
Creators - without role: J. Bousquet - Centre Hospitalier Universitaire de Montpellier
J.M. Anto - Center for Research in Environmental Epidemiology
M. Akdis - University of Zurich
C. Auffray - Centre National de la Recherche Scientifique
T. Keil - Charité - Universitätsmedizin Berlin
I. Momas - Université Paris Cité
D.S. Postma - University of Groningen
R. Valenta - Medical University of Vienna
M. Wickman - Karolinska Institutet
A. Cambon-Thomsen - Université Toulouse III - Paul Sabatier
T. Haahtela - Helsinki University Hospital
B.N. Lambrecht - VIB-UGent Center for Inflammation Research
K. C. Lodrup Carlsen
G.H. Koppelman - University of Groningen
J. Sunyer - Center for Research in Environmental Epidemiology
T. Zuberbier - Charité - Universitätsmedizin Berlin
Isabella Annesi-Maesano - Inserm
A. Arno
C. Bindslev-Jensen - Odense University Hospital
G. de Carlo - European Federation of Allergy and Airways Diseases Patients Associations
F. Forastiere - Agenzia Regionale Parchi
J. Heinrich - Helmholtz Zentrum München
M. Kowalski - Medical University of Lodz
D. Maier - Biomax Informatics
E. Melén - University of Groningen
S. Palkonen - European Federation of Allergy and Airways Diseases Patients Associations
H.A. Smit - University Medical Center Utrecht
M. Standl - Helmholtz Zentrum München
J. Wright - Bradford Royal Infirmary
A. Asarnoj - Karolinska Institutet
M. Benet - Center for Research in Environmental Epidemiology
N. Ballardini - Sachs' Children and Youth Hospital
J. Garcia-Aymerich - Center for Research in Environmental Epidemiology
U. Gehring - Utrecht University
S. Guerra - Center for Research in Environmental Epidemiology
C. Hohman - Charité - Universitätsmedizin Berlin
I. Kull - Sachs' Children and Youth Hospital
C. Lupinek - Medical University of Vienna
M. Pinart - Center for Research in Environmental Epidemiology
I. Skrindo - University of Oslo
M. Westman - Karolinska Institutet
D. Smagghe - Inserm
C. Akdis - University of Zurich
R. Albang - Biomax Informatics
V. Anastasova - Université Toulouse III - Paul Sabatier
N. Anderson - Karolinska Institutet
C. Bachert - Ghent University Hospital
S. Ballereau - Université Claude Bernard Lyon 1
F. Ballester - Universitat de València
X. Basagaña - Center for Research in Environmental Epidemiology
A. Bedbrook - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
A. Bergstrom - Karolinska Institutet
A. von Berg - Marien Hospital Wesel
B. Brunekreef - University Medical Center Utrecht
E. Burte - Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
K. Carlsen - Oslo University Hospital
L. Chatzi - University of Crete
J.M. Coquet - Ghent University
M. Curin - Medical University of Vienna
P. Demoly - Université de Montpellier
E. Eller - Odense University Hospital
M.P. Fantini - University of Bologna
B. Gerhard - Biomax Informatics
H. Hammad - VIB-UGent Center for Inflammation Research
L. von Hertzen - Helsinki University Hospital
V. Hovland - University of Oslo
B. Jacquemin - Center for Research in Environmental Epidemiology
J. Just - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
T. Keller - Charité - Universitätsmedizin Berlin
M. Kerkhof - University Medical Center Groningen
R. Kiss - Medical University of Vienna
M. Kogevinas - Center for Research in Environmental Epidemiology
S. Koletzko - Ludwig-Maximilians-Universität München
S. Lau - Charité - Universitätsmedizin Berlin
I. Lehmann - Helmholtz Centre for Environmental Research
N. Lemonnier - Université Claude Bernard Lyon 1
R. Mceachan - Bradford Royal Infirmary
M. Mäkelä - Helsinki University Hospital
J. Mestres - Pompeu Fabra University
E. Minina - Biomax Informatics
P. Mowinckel - Oslo University Hospital
R. Nadif - Inserm
M. Nawijn - University of Groningen
S. Oddie - Bradford Royal Infirmary
J. Pellet - Université Claude Bernard Lyon 1
I. Pin - Centre Hospitalier Universitaire de Grenoble
D. Porta - Agenzia Regionale Parchi
F. Rancière - Sorbonne Paris Cité
A. Rial-Sebbag - Inserm
Y. Saeys - Ghent University
M.J. Schuijs - VIB-UGent Center for Inflammation Research
V. Siroux - Inserm
C.G. Tischer - Helmholtz Zentrum München
M. Torrent - Parc de Salut
R. Varraso - Inserm
J. de Vocht - European Federation of Allergy and Airways Diseases Patients Associations
K. Wenger - Biomax Informatics
S. Wieser - Medical University of Vienna
C. Xu - University Medical Center Groningen
Publication Details: Allergy, Vol.71(11), pp.1513 - 1525
Identifiers: 9943687009311
Academic Unit: Université de Montpellier
Language: English
Resource Type: Journal article
Local Fields: hal-01872911