Pathophysiology of Chylous Anasarca Caused by Lymphatic Occlusion: A Case Report and Review of the Literature

Antoine Mathivet; Martin Bertrand; Isabelle Quere; Jean-Christophe Gris; Julien Ghelfi; Julien Frandon

doi:10.3390/jpm15060216

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Pathophysiology of Chylous Anasarca Caused by Lymphatic Occlusion: A Case Report and Review of the Literature

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Pathophysiology of Chylous Anasarca Caused by Lymphatic Occlusion: A Case Report and Review of the Literature

Antoine Mathivet, Martin Bertrand, Isabelle Quere, Jean-Christophe Gris, Julien Ghelfi et Julien Frandon

Journal of personalized medicine, Vol.15(6), p.216

26/05/2025

DOI: https://doi.org/10.3390/jpm15060216

PMID: 40559079

Résumé

Case Report

Objective: The aim of this study was to propose a pathophysiological hypothesis for the occurrence of non-traumatic chylous effusions and Central Conducting Lymphatic Anomalies (CCLAs) related to lymphatic occlusion. Methods: We investigated the case of a 39-year-old woman managed at Nîmes University Hospital for chylous anasarca related to an endoluminal lymphatic occlusion. We then conducted a comprehensive review of the literature on CCLAs. Results: Lymphatic drainage is a dynamic process. Obstacles to lymphatic drainage via the thoracic duct can lead to chylous anasarca, depending on where the obstruction is. Lymphatic occlusion seems to be an explanation for certain CCLAs. Conclusions: Understanding CCLAs via the theory of lymph occlusion opens the way to new therapeutic options, but requires further investigation in order to personalize the patient’s treatment.

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Titre: Pathophysiology of Chylous Anasarca Caused by Lymphatic Occlusion: A Case Report and Review of the Literature
Créateurs - sans rôle: Antoine Mathivet - Centre Hospitalier Universitaire Nîmes, Place du Pr R. Debré, 30029 Nîmes, France Department of Medicine, Université de Montpellier, 163 Rue Auguste Broussonnet, 34090 Montpellier, France Centre Hospitalier Universitaire de Montpellier, 191 Av. Doyen Gaston Giraud, 34090 Montpellier, France Department of Radiology, Grenoble-Alpes University Hospital, 38700 Grenoble, France
Martin Bertrand - Centre Hospitalier Universitaire Nîmes, Place du Pr R. Debré, 30029 Nîmes, France Department of Medicine, Université de Montpellier, 163 Rue Auguste Broussonnet, 34090 Montpellier, France Centre Hospitalier Universitaire de Montpellier, 191 Av. Doyen Gaston Giraud, 34090 Montpellier, France Department of Radiology, Grenoble-Alpes University Hospital, 38700 Grenoble, France
Isabelle Quere - Université de Montpellier
Jean-Christophe Gris - Centre Hospitalier Universitaire Nîmes, Place du Pr R. Debré, 30029 Nîmes, France Department of Medicine, Université de Montpellier, 163 Rue Auguste Broussonnet, 34090 Montpellier, France Centre Hospitalier Universitaire de Montpellier, 191 Av. Doyen Gaston Giraud, 34090 Montpellier, France Department of Radiology, Grenoble-Alpes University Hospital, 38700 Grenoble, France
Julien Ghelfi - Centre Hospitalier Universitaire Nîmes, Place du Pr R. Debré, 30029 Nîmes, France Department of Medicine, Université de Montpellier, 163 Rue Auguste Broussonnet, 34090 Montpellier, France Centre Hospitalier Universitaire de Montpellier, 191 Av. Doyen Gaston Giraud, 34090 Montpellier, France Department of Radiology, Grenoble-Alpes University Hospital, 38700 Grenoble, France
Julien Frandon - Centre Hospitalier Universitaire Nîmes, Place du Pr R. Debré, 30029 Nîmes, France Department of Medicine, Université de Montpellier, 163 Rue Auguste Broussonnet, 34090 Montpellier, France Centre Hospitalier Universitaire de Montpellier, 191 Av. Doyen Gaston Giraud, 34090 Montpellier, France Department of Radiology, Grenoble-Alpes University Hospital, 38700 Grenoble, France
Détails de publication: Journal of personalized medicine, Vol.15(6), p.216
Éditeur: MDPI
Identifiants: 99139046809311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE; Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article