Past and current routes to β-hydroperoxy alcohols: A functional group with high potential in organic synthesis

Corentin Bordier; Vincent Escande; Christophe Darcel

doi:10.1016/j.tet.2021.132379

Retour

Past and current routes to β-hydroperoxy alcohols: A functional group with high potential in organic synthesis

Article de revue

Avec comité de lecture

Past and current routes to β-hydroperoxy alcohols: A functional group with high potential in organic synthesis

Corentin Bordier, Vincent Escande et Christophe Darcel

Tetrahedron, Vol.97, p.132379

24/09/2021

DOI: https://doi.org/10.1016/j.tet.2021.132379

Résumé

1,2,4-trioxanes

Hydrogen peroxide

Perhydrolysis

Singlet oxygen

β-hydroxy hydroperoxides

This review aims to showcase the high potential of β-hydroperoxy alcohols (HPA) as intermediates in molecular chemistry in both academic and industrial areas. In particular, these are crucial intermediates for the synthesis of 1,2,4-trioxanes, essential motifs in numerous anti-malarial drugs including the lead artemisinin. The aim of this review is to report the main pathways of preparation of HPAs, more particularly highlighting the selective opening of epoxides by hydrogen peroxide solutions or the use of singlet oxygen for the photooxygenation of allylic alcohols. © 2021 Elsevier Science. All rights reserved. [Display omitted]

Indicateurs

1 Consultations de la notice

Détails

Titre: Past and current routes to β-hydroperoxy alcohols: A functional group with high potential in organic synthesis
Créateurs - sans rôle: Corentin Bordier - Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000, Rennes, France
Vincent Escande - Labcom GreenCARE, Demeta-Université de Rennes 1-CNRS joint laboratory, France
Christophe Darcel - Université de Rennes
Détails de publication: Tetrahedron, Vol.97, p.132379
Éditeur: Elsevier Ltd
Identifiants: 99139197409311
Unité académique: Institut Charles Gerhardt Montpellier - ICGM
Langue: English
Type de ressource: Journal article