PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis

Luca Bartesaghi; Yiqiao Wang; Paula Fontanet; Simone Wanderoy; Finja Berger; Haohao Wu; Natalia Akkuratova; Filipa Boucanova; Jean-Jacques Medard; Charles Petitpre; Mark A. Landy; Ming-Dong Zhang; Philip Harrer; Claudia Stendel; Rolf Stucka; Marina Dusl; Maria Eleni Kastriti; Laura Croci; Helen C. Lai; Gian Giacomo Consalez; Alexandre Pattyn; Patrik Ernfors; Jan Senderek; Igor Adameyko; Francois Lallemend; Saida Hadjab; Roman Chrast

doi:10.1016/j.celrep.2019.02.098

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PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis

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PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis

Luca Bartesaghi, Yiqiao Wang, Paula Fontanet, Simone Wanderoy, Finja Berger, Haohao Wu, Natalia Akkuratova, Filipa Boucanova, Jean-Jacques Medard, Charles Petitpre, …

Cell reports (Cambridge), Vol.26(13), pp.3484-3492.e4

26/03/2019

DOI: https://doi.org/10.1016/j.celrep.2019.02.098

PMID: 30917305

Résumé

Cell Biology

Life Sciences & Biomedicine

Science & Technology

The sensation of pain is essential for the preservation of the functional integrity of the body. However, the key molecular regulators necessary for the initiation of the development of pain-sensing neurons have remained largely unknown. Here, we report that, in mice, inactivation of the transcriptional regulator PRDM12, which is essential for pain perception in humans, results in a complete absence of the nociceptive lineage, while proprioceptive and touch-sensitive neurons remain. Mechanistically, our data reveal that PRDM12 is required for initiation of neurogenesis and activation of a cascade of downstream pro-neuronal transcription factors, including NEUROD1, BRN3A, and ISL1, in the nociceptive lineage while it represses alternative fates other than nociceptors in progenitor cells. Our results thus demonstrate that PRDM12 is necessary for the generation of the entire lineage of pain-initiating neurons.

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Titre: PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
Créateurs - sans rôle: Luca Bartesaghi - Karolinska Institutet
Yiqiao Wang - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Paula Fontanet - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Simone Wanderoy - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Finja Berger - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Haohao Wu - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Natalia Akkuratova - Karolinska Inst, Dept Physiol & Pharmacol, S-17165 Stockholm, Sweden
Filipa Boucanova - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Jean-Jacques Medard - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Charles Petitpre - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Mark A. Landy - UT Southwestern Med Ctr, Dept Neurosci, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
Ming-Dong Zhang - Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, S-17165 Stockholm, Sweden
Philip Harrer - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurol, Friedrich Baur Inst, Munich, Germany
Claudia Stendel - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurol, Friedrich Baur Inst, Munich, Germany
Rolf Stucka - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurol, Friedrich Baur Inst, Munich, Germany
Marina Dusl - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurol, Friedrich Baur Inst, Munich, Germany
Maria Eleni Kastriti - Karolinska Inst, Dept Physiol & Pharmacol, S-17165 Stockholm, Sweden
Laura Croci - Med Univ Vienna, Ctr Brain Res, Vienna, Austria
Helen C. Lai - UT Southwestern Med Ctr, Dept Neurosci, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
Gian Giacomo Consalez - Univ Vita Salute San Raffaele, I-20132 Milan, Italy
Alexandre Pattyn - Hop St Eloi, Inst Neurosci Montpellier, UMR1051, INSERM, F-34000 Montpellier, France
Patrik Ernfors - Karolinska Institutet
Jan Senderek - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurol, Friedrich Baur Inst, Munich, Germany
Igor Adameyko - Karolinska Inst, Dept Physiol & Pharmacol, S-17165 Stockholm, Sweden
Francois Lallemend - Karolinska Institutet
Saida Hadjab - Karolinska Inst, Dept Neurosci, S-17165 Stockholm, Sweden
Roman Chrast - Karolinska Institutet
Détails de publication: Cell reports (Cambridge), Vol.26(13), pp.3484-3492.e4
Éditeur: Elsevier
Nombre de pages: 13
Note de subvention: Swedish Brain Foundation 01GM1511B / German Federal Ministry of Education and Research (BMBF); Federal Ministry of Education & Research (BMBF) 19-15-13023 / Russian Science Foundation; Russian Science Foundation (RSF) Az.10.15.1.021MN / Fritz-Thyssen-Stiftung Swedish Research Council Ake Wiberg Foundation 36/2014 / LMU FoeFoLe program StratNeuro 16-15-10273 / Russian Science Foundation; Russian Science Foundation (RSF) Knut and Alice Wallenberg Foundation (Wallenberg Academy Fellow)
Identifiants: 99155025009311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article