Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Céline Vanderplanck; Alexandra Tassin; Eugénie Ansseau; Sébastien Charron; Armelle Wauters; Céline Lancelot; Kelly Vancutsem; Dalila D. Laoudj-Chenivesse; Alexandra Belayew; Frédérique Coppée

doi:10.1186/s13395-017-0148-4

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Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

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Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Céline Vanderplanck, Alexandra Tassin, Eugénie Ansseau, Sébastien Charron, Armelle Wauters, Céline Lancelot, Kelly Vancutsem, Dalila D. Laoudj-Chenivesse, Alexandra Belayew and Frédérique Coppée

Skeletal Muscle, Vol.8(1)

12/01/2018

DOI: https://doi.org/10.1186/s13395-017-0148-4

PMID: 29329560

Abstract

β-catenin

Cytoskeleton

Differentiation

Proliferation

Disorganized myotubes

Myonuclear clustering

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Title: Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei
Creators - without role: Céline Vanderplanck - University of Mons
Alexandra Tassin - University of Mons
Eugénie Ansseau - University of Mons
Sébastien Charron - University of Mons
Armelle Wauters - University of Mons
Céline Lancelot - University of Mons
Kelly Vancutsem - University of Mons
Dalila D. Laoudj-Chenivesse - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Alexandra Belayew - University of Mons
Frédérique Coppée - University of Mons
Publication Details: Skeletal Muscle, Vol.8(1)
Grant note: We acknowledge the funding from the Association Belge contre les MaladiesNeuro-Musculaires (https://www.telethon.be/), the Association Française contreles Myopathies (www.afm-telethon.fr), and the FSH Society (USA) (https://www.fshsociety.org).CV successively held a doctoral fellowship from the Fonds pour la Formation àla Recherche dans l’Industrie et dans l’Agriculture (FRIA Belgium) (www.fnrs.be)and the FSHD Global Foundation (Australia) (http://fshdglobal.org/). EA and ATwere post-doctoral associates of the Fonds National de la Recherche Scientifique(http://www.fnrs.be) (Belgium)
Identifiers: 9943827809311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: inserm-01683560