Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

C.E. Geyer; J.E. Garber; R.D. Gelber; G. Yothers; M. Taboada; L. Ross; P. Rastogi; K. Cui; A. Arahmani; G. Aktan; A.C. Armstrong; M. Arnedos; J. Balmaña; J. Bergh; J. Bliss; S. Delaloge; S.M. Domchek; A. Eisen; F. Elsafy; L.E. Fein; A. Fielding; J.M. Ford; S. Friedman; K.A. Gelmon; L. Gianni; M. Gnant; S.J. Hollingsworth; S.-A. Im; A. Jager; Ó. Þ Jóhannsson; S.R. Lakhani; W. Janni; B. Linderholm; T.-W. Liu; N. Loman; L. Korde; S. Loibl; P.C. Lucas; F. Marmé; E. Martinez de Dueñas; R. McConnell; K.-A. Phillips; M. Piccart; G. Rossi; R. Schmutzler; E. Senkus; Z. Shao; P. Sharma; C.F. Singer; T. Španić; E. Stickeler; M. Toi; T.A. Traina; G. Viale; G. Zoppoli; Y.H. Park; R. Yerushalmi; H. Yang; D. Pang; K.H. Jung; A. Mailliez; Z. Fan; I. Tennevet; J. Zhang; T. Nagy; G.S. Sonke; Q. Sun; M. Parton; M.A. Colleoni; M. Schmidt; A.M. Brufsky; W. Razaq; B. Kaufman; D. Cameron; C. Campbell; A.N.J. Tutt; Paul Sevelda; Ferdinand Haslbauer; Monika Penzinger; Leopold Öhler; Christoph Tinchon; Richard Greil; Sonja Heibl; Rupert Bartsch; Viktor Wette; Christian F. Singer; Claudia Pasterk; Ruth Helfgott; Gunda Pristauz-Telsnigg; Herbert Stöger; Angsar Weltermann; Daniel Egle; Irene Thiel; David Fuchs; Holger Rumpold; Kathrin Strasser-Weippl; Beate Rautenberg; Volkmar Müller; Marcus Schmidt; Stefan Paepke; Mustafa Aydogdu; Christoph Thomssen; Joachim Rom; Christine Mau; Peter Fasching; Uwe-Jochen Göhring; Thorsten Kühn; Stefanie Noeding; Sherko Kümmel; John Hackmann; Elmar Stickeler; Abhishek Joshi; Joanna Dewar; Michael Friedlander; Kelly-Anne Phillips; Yoland Antill; Natasha Woodward; Ehtesham Abdi; Susan Tiley; Mathew George; David Boadle; Annabel Goodwin; Andre van der Westhuizen; George Kannourakis; Nicholas Murray; Nicole McCarthy; Judith Kroep; Maaike de Boer; Joan Heijns; Agnes Jager; Franciscus Erdkamp; Sandra Bakker; Gabe S. Sonke; Amer Sami; John Mackey; Catherine Prady; Andrea Eisen; Christine Desbiens; Erica Patocskai; Cristiano Ferrario; Karen Gelmon; Louise Bordeleau; Haji Chalchal; Saroj Niraula; ido wolf; Elżbieta Senkus; François Duhoux; Randal d’Hondt; Sylvie Luce; Daphné t’Kint de Roodenbeke; Konstantinos Papadimitriou; Marleen Borms; Claire Quaghebeur; William Jacot; Etienne Brain; Laurence Venat-Bouvet; Alain Lortholary; Zbigniew Nowecki; Fátima Cardoso; Richard Hayward; Santiago Bella; Mauricio Fernández Lazzaro; Norma Pilnik; Luis E. Fein; Cesar Blajman; Guillermo Lerzo; Mirta Varela; Juan Jose Zarba; Diego Kaen; Maria Victoria Constanzo; Joke Tio; Wulf Siggelkow; Christian Jackisch; Eva Maria Grischke; Dirk Zahm; Sara Tato-Varela; Sabine Schmatloch; Peter Klare; Andrea Stefek; Kerstin Rhiem; Oliver Hoffmann; Mustafa Deryal; Isolde Gröll; Peter Ledwon; Christoph Uleer; Petra Krabisch; Jochem Potenberg; Maren Darsow; Tjoung-Won Park-Simon; Heinz-Gert Höffkes; Till-Oliver Emde; Gerd Graffunder; Oliver Tomé; Dirk Forstmeyer; Jürgen Terhaag; Christoph Salat; Karin Kast; Steffi Weniger; Carsten Schreiber; Bernhard Heinrich; Max Dieterich; Michaela Penelope Wüllner; Raquel Andrés Conejero; José Ángel García Sáenz; Lourdes Calvo Martinez; Angels Arcusa Lanza; Serafín Morales Murillo; Fernando Henao Carrasco; Salvador Blanch Tormo; Isabel Álvarez López; Juan Ignacio Delgado Mingorance; Elena Álvarez Gomez; Marta Santisteban; Josefina Cruz Jurado; Vanesa Quiroga; Manuel Ruiz Borrego; Eduardo Martínez de Dueñas; Jose Enrique Alés Martínez; Juan De la Haba; Noelia Martínez Jañez; Álvaro Rodríguez Lescure; Antonio Antón Torres; Gema Llort Crusades; Santiago González-Santiago; Antonia Marquez Aragones; Ana Laura Ortega; Agusti Barnadas Molins; José Ignacio Chacón López-Muñiz; Miguel Martín Jiménez; Ana Santaballa Bertrán; César Rodríguez; Lucía González Cortijo; Elisabetta Cretella; Laura Cortesi; Enzo Maria Ruggeri; Claudio Verusio; Stefania Gori; Andrea Bonetti; Anna Maria Mosconi; Oskar Johannsson; Guy Jerusalem; Patrick Neven; Tünde Nagy; Graziella Pinotti; Marco A. Colleoni; Antonio Bernardo; Lorenzo Gianni; Eraldo Bucci; Laura Biganzoli; Konstantin Dedes; Urban Novak; Khalil Zaman; Jeremy Braybrooke; Matthew Winter; Daniel Rea; Muireann Kelleher; Sophie Barrett; Stephen Chan; Tamas Hickish; Jane Hurwitz; John Conibear; Apurna Jegannathen; Marina Parton; Andrew Tutt; Rozenn Allerton; Annabel Borley; Anne Armstrong; Ellen Copson; Nicola Levitt; Jean Abraham; Timothy Perren; Rebecca Roylance; Kazushige Ishida; Tatsuya Toyama; Norikazu Masuda; Junichiro Watanabe; Eriko Tokunaga; Takayuki Kinoshita; Yoshiaki Rai; Masahiro Takada; Yasuhiro Yanagita; Rikiya Nakamura; Takahiro Nakayama; Yasuto Naoi; Hiroji Iwata; Seigo Nakamura; Masato Takahashi; Kenjiro Aogi; Koichiro Tsugawa; Hirofumi Mukai; Toshimi Takano; Akihiko Osaki; Nobuaki Sato; Hideko Yamauchi; Yutaka Tokuda; Mitsuya Ito; Takeki Sugimoto; Shakeela W. Bahadur; Patricia A. Ganz; Min J. Lu; Monica M. Mita; James Waisman; Jonathan A. Polikoff; Melinda L. Telli; Samantha A. Seaward; J. Marie Suga; Lara N. Durna; Jennifer Fu Carney; Alex Menter; Ajithkumar Puthillath; Nitin Rohatgi; James H. Feusner; Kristie A. Bobolis; Peter D. Eisenberg; Derrick Wong; Virginia F. Borges; Alexander T. Urquhart; Erin W. Hofstatter; Edward C. McCarron; Claudine Isaacs; Pia Herbolsheimer; Ramya Varadarajan; Adam Raben; Ruby Anne E. Deveras; Frances Valdes-Albini; Reshma L. Mahtani; Jane L. Meisel; Bradley T. Sumrall; Cheryl F. Jones; Samuel N. Ofori; Kenneth N.M. Sumida; Mark Karwal; Deborah W. Wilbur; (Joe) Singh; David M. Spector; John Schallenkamp; Douglas E. Merkel; Shelly S. Lo; Pam G. Khosla; Massimo Cristofanilli; Lisa Flaum; Kent F. Hoskins; Melody A. Cobleigh; Elyse A. Lambiase; Olwen M. Hahn; Ira A. Oliff; Bryan A. Faller; James L. Wade; Nafisa D. Burhani; Amaryllis Gil; Harvey E. Einhorn; Anna M.V. Storniolo; Brian K. Chang; Maitri Kalra; Erwin L. Robin; Bilal Ansari; Priyanka Sharma; Shaker R. Dakhil; Richard L. Deming; John T. Cole; David S. Hanson; Augusto C. Ochoa; Judy E. Garber; Harvey Zimbler; Deborah K. Armstrong; Katherine H.R. Tkaczuk; David A. Riseberg; Brian M. O'Connor; Thomas H. Openshaw; Dana Zakalik; Cynthia M. Vakhariya; Anne F. Schott; Michael S. Simon; Thomas J. Doyle; Tareq Al Baghdadi; Amy VanderWoude; Patrick J. Flynn; Richard T. Zera; Bret E.B. Friday; Kathryn J. Ruddy; Ron Smith; Ademuyiwa; Foluso Olabisi; Robert Ellis; Jay W. Carlson; Marchello; Benjamin T; Edward A. Levine; Paul K. Marcom; Cameron B. Harkness; Antoinette R. Tan; William J. Charles; Charles S. Kuzma; Shonda Asaad; James E. Radford; Preston D. Steen; Madhu Unnikrishnan; Grant R. Seeger; Kirsten M.H. Leu; Mehmet S. Copur; Ralph J. Hauke; Gamini S. Soori; Bradley A. Arrick; Jennifer G. Reeder; Deborah L. Toppmeyer; Zoneddy R. Dayao; Sylvia Adams; Eleni Andreopoulou; Magnuson Allison; Jesus D. Anampa Mesias; Ruby Sharma; Bhuvaneswari Ramaswamy; Aaron T. Gerds; Robert R. Shenk; Howard M. Gross; Shruti Trehan; Wajeeha Razaq; Abdul H. Mansoor; Christie J. Hilton; Adam M. Brufsky; Chanh Huynh; Nabila Chowdhury; Susan M. Domchek; Elin R. Sigurdson; Terrence P. Cescon; Marc A. Rovito; Albert S. DeNittis; Victor G. Vogel; Thomas B. Julian; L.E. Boyle; Luis Baez-Diaz; Frank J. Brescia; John E. Doster; Robert D. Siegel; Lucas Wong; Tejal Patel; Julie R. Nangia; Catherine A. Jones; George M. Cannon; Harry D. Bear; Hetal Vachhani; Mary Wilkinson; Marie E. Wood; Fengting Yan; Xingwei Sui; Carol M. van Haelst; Jennifer M. Specht; Ying Zhuo; Rubina Qamar; Matthew L. Ryan; Abigail Stockham; Shamsuddin Virani; Arlene A. Gayle; Steven J. Jubelirer; Sobha Kurian; Mohamad A. Salkeni; Niklas Loman; Barbro Linderholm; Gustav Silander; Anna-Lotta Hallbeck; Anna von Wachenfeldt Väppling; Elsa Curtit; Catarina Cardoso; Sofia Braga; Miguel Abreu; Mafalda Casa-Nova; Mónica Nave; Eva María Ciruelos Gil; Judith Balmaña Gelpi; Adela Fernández Ortega; Josep Gumà Padró; Begoña Bermejo de las Heras; María González Cao; Juan Cueva Bañuelos; Jesús Alarcon Company; Gemma Viñas Villaró; Laura García Estevez; Jens Huober; Steffi Busch; Tanja Fehm; Antje Hahn; Andrea Grafe; Thomas Noesselt; Thomas Dewitz; Harald Wagner; Christina Bechtner; Michael Weigel; Hans-Christian Kolberg; Thomas Decker; Jörg Thomalla; Tobias Hesse; Nadia Harbeck; Jan Schröder Jens-Uwe Blohmer; Marc Wolf Sütterlin; Renske Altena; Chang-Fang Chiu; Shin-Cheh Chen; Ming-Feng Hou; Yuan-Ching Chang; Shang-Hung Chen; Shou-Tung Chen; Chiun-Sheng Huang; Dah-Cherng Yeh; Jyh-Cherng Yu; Ling-Ming Tseng; Wei-Pang Chung; Audrey Mailliez; Thierry Petit; Suzette Delaloge; Christelle Lévy; Philippe Dalivoust; Jean-Marc Extra; Marie-Ange Mouret-Reynier; Anne-Claire Hardy-Bessard; Hélène Simon; Tiffenn L'Haridon; Alice Mege; Sylvie Giacchetti; Camille Chakiba-Brugere; Alain Gratet; Virginie Pottier; Jean-Marc Ferrero; Isabelle Tennevet; Christophe Perrin; Jean-Luc Canon; Sofie Joris; OlympiA Clinical Trial Steering Committee and Investigators; Zhimin Shao; Binghe Xu; ZeFei Jiang; Qiang Sun; Kunwei Shen; Da Pang; Jin Zhang; Shui Wang; Hongjian Yang; Ning Liao; Hong Zheng; Peifen Fu; Chuangui Song; Yongsheng Wang; Zhimin Fan; Cuizhi Geng; Olivier Tredan; László Landherr; Bella Kaufman; Rinat Yerushalmi; Beatrice Uziely; Pierfranco Conte; Claudio Zamagni; Giampaolo Bianchini; Michelino De Laurentiis; Carlo Tondini; Vittorio Gebbia; Mariangela Ciccarese; Tomasz Sarosiek; Jacek Mackiewicz; Anna Słowińska; Ewa Kalinka; Tomasz Huzarski; Seock-Ah Im; Kyung Hae Jung; Joo Hyuk Sohn; Jee Hyun Kim; Keun Seok Lee; Yeon Hee Park; Kyoung Eun Lee; Yee Soo Chae; Eun Kyung Cho

doi:10.1016/j.annonc.2022.09.159

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Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

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Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

C.E. Geyer, J.E. Garber, R.D. Gelber, G. Yothers, M. Taboada, L. Ross, P. Rastogi, K. Cui, A. Arahmani, G. Aktan, …

Annals of oncology, Vol.33(12), pp.1250-1268

01/12/2022

DOI: https://doi.org/10.1016/j.annonc.2022.09.159

PMID: 36228963

Résumé

adjuvant therapy

BRCA1/2

breast cancer

olaparib

PARP inhibition

The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewer deaths than the placebo group, but the difference did not reach statistical significance for overall survival (OS). We now report the pre-specified second IA of OS with updates of IDFS, DDFS, and safety. One thousand eight hundred and thirty-six patients were randomly assigned to olaparib or placebo following (neo)adjuvant chemotherapy, surgery, and radiation therapy if indicated. Endocrine therapy was given concurrently with study medication for hormone receptor-positive cancers. Statistical significance for OS at this IA required P < 0.015. With a median follow-up of 3.5 years, the second IA of OS demonstrated significant improvement in the olaparib group relative to the placebo group [hazard ratio 0.68; 98.5% confidence interval (CI) 0.47-0.97; P = 0.009]. Four-year OS was 89.8% in the olaparib group and 86.4% in the placebo group (Δ 3.4%, 95% CI −0.1% to 6.8%). Four-year IDFS for the olaparib group versus placebo group was 82.7% versus 75.4% (Δ 7.3%, 95% CI 3.0% to 11.5%) and 4-year DDFS was 86.5% versus 79.1% (Δ 7.4%, 95% CI 3.6% to 11.3%), respectively. Subset analyses for OS, IDFS, and DDFS demonstrated benefit across major subgroups. No new safety signals were identified including no new cases of acute myeloid leukemia or myelodysplastic syndrome. With 3.5 years of median follow-up, OlympiA demonstrates statistically significant improvement in OS with adjuvant olaparib compared with placebo for gBRCA1/2pv-associated EBC and maintained improvements in the previously reported, statistically significant endpoints of IDFS and DDFS with no new safety signals. •Adjuvant olaparib versus placebo significantly improved OS in gBRCA1/2pv-associated human epidermal growth factor receptor 2-negative EBC (4-year OS 90% versus 86%).•Adjuvant olaparib versus placebo improved 4-year IDFS (83% versus 75%) and 4-year DDFS (87% versus 79%).•Adjuvant olaparib demonstrated benefit across major subgroups for OS, IDFS, and DDFS, including by hormone receptor status.•With 3.5 years of median follow-up there were two acute myeloid leukemia/myelodysplastic syndrome cases (0.2%) with olaparib and three (0.3%) with placebo.•With 1-year of additional follow-up, no new safety signals were identified with adjuvant olaparib compared to placebo.

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Titre: Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
Créateurs - sans rôle: C.E. Geyer - NRG Oncology/NSABP Foundation, Pittsburgh
J.E. Garber - Dana-Farber Cancer Institute
R.D. Gelber - Dana-Farber Cancer Institute
G. Yothers - NRG Oncology/NSABP Foundation, Pittsburgh
M. Taboada - Oncology Biometrics Department, AstraZeneca, Macclesfield
L. Ross - Department of Data Management, Frontier Science (Scotland), Kincraig, Scotland, UK
P. Rastogi - NRG Oncology/NSABP Foundation, Pittsburgh
K. Cui - Department of Oncology R&D, AstraZeneca, Gaithersburg, USA
A. Arahmani - Research Operations Department, Breast International Group, Brussels, Belgium
G. Aktan - Global Oncology Clinical Development, Merck and Co. Inc., Rahway, USA
A.C. Armstrong - Department of Medical Oncology, The Christie Hospital NHS Foundation Trust Manchester, UK
M. Arnedos - European Organisation for Research and Treatment (EORTC), Brussels, Belgium
J. Balmaña - Medical Oncology Department, Vall d’Hebron Institute of Oncology and Vall d’Hebron University Hospital, Barcelona, Spain
J. Bergh - Department of Oncology-Pathology, Swedish Breast Cancer Group, Karolinska Institute and Breast Cancer Center, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden
J. Bliss - Department of Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK
S. Delaloge - Department of Cancer Medicine, Institute Gustave Roussy and Unicancer Breast Group, Paris, France
S.M. Domchek - University of Pennsylvania
A. Eisen - Odette Cancer Centre, Department of Medicine, University of Toronto, Toronto, Canada
F. Elsafy - Oncology Biometrics Department, AstraZeneca, Macclesfield
L.E. Fein - Department of Clinical Research, Instituto de Oncologia De Rosario, Santa Fe, Argentina
A. Fielding - Department of Oncology R&D, AstraZeneca, Gaithersburg, USA
J.M. Ford - Department of Medicine/Oncology, Stanford University School of Medicine, Stanford
S. Friedman - Facing Our Risk of Cancer Empowered, Tampa, USA
K.A. Gelmon - Department of Medical Oncology, BC Cancer, Vancouver, Canada
L. Gianni - Department of Oncology, International Breast Cancer Study Group, Bern, Switzerland
M. Gnant - Medical University of Vienna
S.J. Hollingsworth - Department of Late Development Oncology, AstraZeneca, Cambridge, UK
S.-A. Im - Department of Internal Medicine, Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
A. Jager - Department of Medical Oncology, Dutch Breast Cancer Research Group, Utrecht, the Netherlands
Ó. Þ Jóhannsson - Department of Medical Oncology, Landspítali University Hospital of Iceland, Icelandic Breast Cancer Group, Reykjavik, Iceland
S.R. Lakhani - Department of Anatomical Pathology, The University of Queensland Centre for Clinical Research and Pathology Queensland, Brisbane, Australia
W. Janni - Department for Obstetrics and Gynecology, Universitaetsklinikum, University of Ulm, Ulm, Germany
B. Linderholm - Department of Oncology, Sahlgrenska University Hospital, Gothenburg
T.-W. Liu - Division of Cancer Research, National Health Research Institutes, Taiwan Cooperative Oncology Group, Taipei City, Taiwan
N. Loman - Department of Hematology, Oncology, and Radiation Physics, Swedish Association of Breast Oncologists, Skåne University Hospital, Lund, Sweden
L. Korde - Clinical Investigations Branch, Division of Cancer Treatment and Diagnosis, The National Cancer Institute, Rockville, USA
S. Loibl - German Breast group
P.C. Lucas - NRG Oncology/NSABP Foundation, Pittsburgh
F. Marmé - Medical Faculty Mannheim, Heidelberg University, Mannheim Germany and the German Breast Group, Neu-Isenburg, Germany
E. Martinez de Dueñas - Médica Consorcio Hospitalario Provincial de Castellón, Servicio de Oncología, Castellón, Spain
R. McConnell - Department of Data Management, Frontier Science (Scotland), Kincraig, Scotland, UK
K.-A. Phillips - Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne
M. Piccart - Department of Scientific Direction, Institut Jules Bordet, l’Université Libre de Bruxelles, Brussels
G. Rossi - Department of Research and Development, Breast International Group, Brussels, Belgium
R. Schmutzler - The Center for Familial Breast and Ovarian Cancer and the Center for Integrated Oncology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
E. Senkus - Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland
Z. Shao - Fudan University Shanghai Cancer Center, Shanghai, China
P. Sharma - Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, USA
C.F. Singer - Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
T. Španić - Department of Patient Advocacy, Europa Donna-The European Breast Cancer Coalition, Milan, Italy
E. Stickeler - Department of Obstetrics and Gynecology, University Hospital Aachen, Aachen, Germany
M. Toi - Department of Breast Surgery Kyoto University Hospital, Kyoto, Japan
T.A. Traina - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
G. Viale - Department of Pathology, University of Milan, European Institute of Oncology IRCCS, Milan
G. Zoppoli - Internal Medicine Oncology Unit, Gruppo Oncologico Italiano di Ricerca Clinica, Parma
Y.H. Park - Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
R. Yerushalmi - Department of Oncology, Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petach Tikva
H. Yang - Department of Breast Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou
D. Pang - Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China
K.H. Jung - Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
A. Mailliez - Department of Medical Oncology, Breast Cancer Unit, Oscar Lambret Center, Lillie, France
Z. Fan - Department of Breast Surgery, First Hospital of Jilin University, Jilin, China
I. Tennevet - Department of Medical Oncology, Centre Henri Becquerel, Rouen, France
J. Zhang - Breast Cancer Center, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China
T. Nagy - Chemotherapy Department B, Országos Onkológiai Intézet, National Institute of Oncology, Budapest, Hungary
G.S. Sonke - Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands
Q. Sun - Department of Breast Surgery, Peking Union Medical College Hospital, Peking, China
M. Parton - Breast Unit, Royal Marsden Hospital, London, UK
M.A. Colleoni - Division of Medical Senology, European Institute of Oncology (IEO), IRCCS, Milan
M. Schmidt - Department of Obstetrics and Gynecology, University Medical Center Mainz, Mainz, Germany
A.M. Brufsky - NRG Oncology/NSABP Foundation, Pittsburgh
W. Razaq - Department of Internal Medicine, Section of Hematology/Oncology, Oklahoma University Health, Oklahoma City, USA
B. Kaufman - The Breast Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel
D. Cameron - University of Edinburgh
C. Campbell - Department of Statistics and Programming, Frontier Science (Scotland), Kincraig, Scotland
A.N.J. Tutt - The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London
Paul Sevelda
Ferdinand Haslbauer
Monika Penzinger
Leopold Öhler
Christoph Tinchon
Richard Greil
Sonja Heibl
Rupert Bartsch
Viktor Wette
Christian F. Singer
Claudia Pasterk
Ruth Helfgott
Gunda Pristauz-Telsnigg
Herbert Stöger
Angsar Weltermann
Daniel Egle
Irene Thiel
David Fuchs
Holger Rumpold
Kathrin Strasser-Weippl
Beate Rautenberg
Volkmar Müller
Marcus Schmidt
Stefan Paepke
Mustafa Aydogdu
Christoph Thomssen
Joachim Rom
Christine Mau
Peter Fasching
Uwe-Jochen Göhring
Thorsten Kühn
Stefanie Noeding
Sherko Kümmel
John Hackmann
Elmar Stickeler
Abhishek Joshi
Joanna Dewar
Michael Friedlander
Kelly-Anne Phillips
Yoland Antill
Natasha Woodward
Ehtesham Abdi
Susan Tiley
Mathew George
David Boadle
Annabel Goodwin
Andre van der Westhuizen
George Kannourakis
Nicholas Murray
Nicole McCarthy
Judith Kroep
Maaike de Boer
Joan Heijns
Agnes Jager
Franciscus Erdkamp
Sandra Bakker
Gabe S. Sonke
Amer Sami
John Mackey
Catherine Prady
Andrea Eisen
Christine Desbiens
Erica Patocskai
Cristiano Ferrario
Karen Gelmon
Louise Bordeleau
Haji Chalchal
Saroj Niraula
ido wolf
Elżbieta Senkus
François Duhoux
Randal d’Hondt
Sylvie Luce
Daphné t’Kint de Roodenbeke
Konstantinos Papadimitriou
Marleen Borms
Claire Quaghebeur
William Jacot
Etienne Brain
Laurence Venat-Bouvet
Alain Lortholary
Zbigniew Nowecki
Fátima Cardoso
Richard Hayward
Santiago Bella
Mauricio Fernández Lazzaro
Norma Pilnik
Luis E. Fein
Cesar Blajman
Guillermo Lerzo
Mirta Varela
Juan Jose Zarba
Diego Kaen
Maria Victoria Constanzo
Joke Tio
Wulf Siggelkow
Christian Jackisch
Eva Maria Grischke
Dirk Zahm
Sara Tato-Varela
Sabine Schmatloch
Peter Klare
Andrea Stefek
Kerstin Rhiem
Oliver Hoffmann
Mustafa Deryal
Isolde Gröll
Peter Ledwon
Christoph Uleer
Petra Krabisch
Jochem Potenberg
Maren Darsow
Tjoung-Won Park-Simon
Heinz-Gert Höffkes
Till-Oliver Emde
Gerd Graffunder
Oliver Tomé
Dirk Forstmeyer
Jürgen Terhaag
Christoph Salat
Karin Kast
Steffi Weniger
Carsten Schreiber
Bernhard Heinrich
Max Dieterich
Michaela Penelope Wüllner
Raquel Andrés Conejero
José Ángel García Sáenz
Lourdes Calvo Martinez
Angels Arcusa Lanza
Serafín Morales Murillo
Fernando Henao Carrasco
Salvador Blanch Tormo
Isabel Álvarez López
Juan Ignacio Delgado Mingorance
Elena Álvarez Gomez
Marta Santisteban
Josefina Cruz Jurado
Vanesa Quiroga
Manuel Ruiz Borrego
Eduardo Martínez de Dueñas
Jose Enrique Alés Martínez
Juan De la Haba
Noelia Martínez Jañez
Álvaro Rodríguez Lescure
Antonio Antón Torres
Gema Llort Crusades
Santiago González-Santiago
Antonia Marquez Aragones
Ana Laura Ortega
Agusti Barnadas Molins
José Ignacio Chacón López-Muñiz
Miguel Martín Jiménez
Ana Santaballa Bertrán
César Rodríguez
Lucía González Cortijo
Elisabetta Cretella
Laura Cortesi
Enzo Maria Ruggeri
Claudio Verusio
Stefania Gori
Andrea Bonetti
Anna Maria Mosconi
Oskar Johannsson
Guy Jerusalem
Patrick Neven
Tünde Nagy
Graziella Pinotti
Marco A. Colleoni
Antonio Bernardo
Lorenzo Gianni
Eraldo Bucci
Laura Biganzoli
Konstantin Dedes
Urban Novak
Khalil Zaman
Jeremy Braybrooke
Matthew Winter
Daniel Rea
Muireann Kelleher
Sophie Barrett
Stephen Chan
Tamas Hickish
Jane Hurwitz
John Conibear
Apurna Jegannathen
Marina Parton
Andrew Tutt
Rozenn Allerton
Annabel Borley
Anne Armstrong
Ellen Copson
Nicola Levitt
Jean Abraham
Timothy Perren
Rebecca Roylance
Kazushige Ishida
Tatsuya Toyama
Norikazu Masuda
Junichiro Watanabe
Eriko Tokunaga
Takayuki Kinoshita
Yoshiaki Rai
Masahiro Takada
Yasuhiro Yanagita
Rikiya Nakamura
Takahiro Nakayama
Yasuto Naoi
Hiroji Iwata
Seigo Nakamura
Masato Takahashi
Kenjiro Aogi
Koichiro Tsugawa
Hirofumi Mukai
Toshimi Takano
Akihiko Osaki
Nobuaki Sato
Hideko Yamauchi
Yutaka Tokuda
Mitsuya Ito
Takeki Sugimoto
Shakeela W. Bahadur
Patricia A. Ganz
Min J. Lu
Monica M. Mita
James Waisman
Jonathan A. Polikoff
Melinda L. Telli
Samantha A. Seaward
J. Marie Suga
Lara N. Durna
Jennifer Fu Carney
Alex Menter
Ajithkumar Puthillath
Nitin Rohatgi
James H. Feusner
Kristie A. Bobolis
Peter D. Eisenberg
Derrick Wong
Virginia F. Borges
Alexander T. Urquhart
Erin W. Hofstatter
Edward C. McCarron
Claudine Isaacs
Pia Herbolsheimer
Ramya Varadarajan
Adam Raben
Ruby Anne E. Deveras
Frances Valdes-Albini
Reshma L. Mahtani
Jane L. Meisel
Bradley T. Sumrall
Cheryl F. Jones
Samuel N. Ofori
Kenneth N.M. Sumida
Mark Karwal
Deborah W. Wilbur
(Joe) Singh
David M. Spector
John Schallenkamp
Douglas E. Merkel
Shelly S. Lo
Pam G. Khosla
Massimo Cristofanilli
Lisa Flaum
Kent F. Hoskins
Melody A. Cobleigh
Elyse A. Lambiase
Olwen M. Hahn
Ira A. Oliff
Bryan A. Faller
James L. Wade
Nafisa D. Burhani
Amaryllis Gil
Harvey E. Einhorn
Anna M.V. Storniolo
Brian K. Chang
Maitri Kalra
Erwin L. Robin
Bilal Ansari
Priyanka Sharma
Shaker R. Dakhil
Richard L. Deming
John T. Cole
David S. Hanson
Augusto C. Ochoa
Judy E. Garber
Harvey Zimbler
Deborah K. Armstrong
Katherine H.R. Tkaczuk
David A. Riseberg
Brian M. O'Connor
Thomas H. Openshaw
Dana Zakalik
Cynthia M. Vakhariya
Anne F. Schott
Michael S. Simon
Thomas J. Doyle
Tareq Al Baghdadi
Amy VanderWoude
Patrick J. Flynn
Richard T. Zera
Bret E.B. Friday
Kathryn J. Ruddy
Ron Smith
Ademuyiwa
Foluso Olabisi
Robert Ellis
Jay W. Carlson
Marchello
Benjamin T
Edward A. Levine
Paul K. Marcom
Cameron B. Harkness
Antoinette R. Tan
William J. Charles
Charles S. Kuzma
Shonda Asaad
James E. Radford
Preston D. Steen
Madhu Unnikrishnan
Grant R. Seeger
Kirsten M.H. Leu
Mehmet S. Copur
Ralph J. Hauke
Gamini S. Soori
Bradley A. Arrick
Jennifer G. Reeder
Deborah L. Toppmeyer
Zoneddy R. Dayao
Sylvia Adams
Eleni Andreopoulou
Magnuson Allison
Jesus D. Anampa Mesias
Ruby Sharma
Bhuvaneswari Ramaswamy
Aaron T. Gerds
Robert R. Shenk
Howard M. Gross
Shruti Trehan
Wajeeha Razaq
Abdul H. Mansoor
Christie J. Hilton
Adam M. Brufsky
Chanh Huynh
Nabila Chowdhury
Susan M. Domchek
Elin R. Sigurdson
Terrence P. Cescon
Marc A. Rovito
Albert S. DeNittis
Victor G. Vogel
Thomas B. Julian
L.E. Boyle
Luis Baez-Diaz
Frank J. Brescia
John E. Doster
Robert D. Siegel
Lucas Wong
Tejal Patel
Julie R. Nangia
Catherine A. Jones
George M. Cannon
Harry D. Bear
Hetal Vachhani
Mary Wilkinson
Marie E. Wood
Fengting Yan
Xingwei Sui
Carol M. van Haelst
Jennifer M. Specht
Ying Zhuo
Rubina Qamar
Matthew L. Ryan
Abigail Stockham
Shamsuddin Virani
Arlene A. Gayle
Steven J. Jubelirer
Sobha Kurian
Mohamad A. Salkeni
Niklas Loman
Barbro Linderholm
Gustav Silander
Anna-Lotta Hallbeck
Anna von Wachenfeldt Väppling
Elsa Curtit
Catarina Cardoso
Sofia Braga
Miguel Abreu
Mafalda Casa-Nova
Mónica Nave
Eva María Ciruelos Gil
Judith Balmaña Gelpi
Adela Fernández Ortega
Josep Gumà Padró
Begoña Bermejo de las Heras
María González Cao
Juan Cueva Bañuelos
Jesús Alarcon Company
Gemma Viñas Villaró
Laura García Estevez
Jens Huober
Steffi Busch
Tanja Fehm
Antje Hahn
Andrea Grafe
Thomas Noesselt
Thomas Dewitz
Harald Wagner
Christina Bechtner
Michael Weigel
Hans-Christian Kolberg
Thomas Decker
Jörg Thomalla
Tobias Hesse
Nadia Harbeck
Jan Schröder Jens-Uwe Blohmer
Marc Wolf Sütterlin
Renske Altena
Chang-Fang Chiu
Shin-Cheh Chen
Ming-Feng Hou
Yuan-Ching Chang
Shang-Hung Chen
Shou-Tung Chen
Chiun-Sheng Huang
Dah-Cherng Yeh
Jyh-Cherng Yu
Ling-Ming Tseng
Wei-Pang Chung
Audrey Mailliez
Thierry Petit
Suzette Delaloge
Christelle Lévy
Philippe Dalivoust
Jean-Marc Extra
Marie-Ange Mouret-Reynier
Anne-Claire Hardy-Bessard
Hélène Simon
Tiffenn L'Haridon
Alice Mege
Sylvie Giacchetti
Camille Chakiba-Brugere
Alain Gratet
Virginie Pottier
Jean-Marc Ferrero
Isabelle Tennevet
Christophe Perrin
Jean-Luc Canon
Sofie Joris
OlympiA Clinical Trial Steering Committee and Investigators
Zhimin Shao
Binghe Xu
ZeFei Jiang
Qiang Sun
Kunwei Shen
Da Pang
Jin Zhang
Shui Wang
Hongjian Yang
Ning Liao
Hong Zheng
Peifen Fu
Chuangui Song
Yongsheng Wang
Zhimin Fan
Cuizhi Geng
Olivier Tredan
László Landherr
Bella Kaufman
Rinat Yerushalmi
Beatrice Uziely
Pierfranco Conte
Claudio Zamagni
Giampaolo Bianchini
Michelino De Laurentiis
Carlo Tondini
Vittorio Gebbia
Mariangela Ciccarese
Tomasz Sarosiek
Jacek Mackiewicz
Anna Słowińska
Ewa Kalinka
Tomasz Huzarski
Seock-Ah Im
Kyung Hae Jung
Joo Hyuk Sohn
Jee Hyun Kim
Keun Seok Lee
Yeon Hee Park
Kyoung Eun Lee
Yee Soo Chae
Eun Kyung Cho
Détails de publication: Annals of oncology, Vol.33(12), pp.1250-1268
Éditeur: Elsevier Ltd
Nombre de pages: 19
Identifiants: 99140163209311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM
Langue: English
Type de ressource: Journal article