Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Sebastian Sattui; Richard Conway; Michael Putman; Andrea Seet; Milena Gianfrancesco; Kaley Beins; Catherine Hill; David Liew; Sarah Mackie; Puja Mehta; Lorna Neill; Gimena Gomez; Maria Isabel Haye Salinas; Federico Nicolas Maldonado; Henrique Ataide Mariz; Samia Araujo de Sousa Studart; Nafice Costa Araujo; Ann Knight; Davide Rozza; Luca Quartuccio; Maxime Samson; Stéphane Bally; Alexandre Tj Maria; Pascal Chazerain; Rebecca Hasseli; Ulf Müller-Ladner; Bimba Hoyer; Reinhard Voll; Rita Pinheiro Torres; Mariana Luis; Sandra Lucia Euzebio Ribeirio; Samar Al-Emadi; Jeffrey Sparks; Tiffany Y-T Hsu; Kristin d'Silva; Naomi Patel; Leanna Wise; Emily Gilbert; Maria Valenzuela Almada; Alí Duarte-García; Manuel Ugarte-Gil; Lindsay Jacobsohn; Zara Izadi; Anja Strangfeld; Elsa Mateus; Kimme Hyrich; Laure Gossec; Loreto Carmona; Saskia Lawson-Tovey; Lianne Kearsley-Fleet; Martin Schaefer; Emily Sirotich; Jonathan Hausmann; Paul Sufka; Suleman Bhana; Jean Liew; Rebecca Grainger; Pedro Machado; Zachary Wallace; Jinoos Yazdany; Philip Robinson; Brahim Dahou; Eva Rath; Yves Piette; Mieke Devinck; Bea Maeyaert; Francinne Machado Ribeiro; Sandra Lucia Euzebio Ribeiro; Marcelo Pinheiro; Rosana Quintana; Karen Roberts; Roberto Miguel Baez; Vanessa Castro Coello; María Haye Salinas; Alvaro Andres Reyes Torres; Gelsomina Alle; Romina Tanten; Hernán Maldonado Ficco; Romina Nieto; Carla Gobbi; Yohana Tissera; Cecilia Pisoni; Alba Paula; Juan Alejandro Albiero; Maria Marcela Schmid; Micaela Cosatti; Maria Julieta Gamba; Carlevaris Leandro; María Alejandra Cusa; Noelia German; Veronica Bellomio; Lorena Takashima; Mariana Pera; Karina Cogo; Maria Soledad Gálvez Elkin; María Alejandra Medina; Veronica Savio; Ivana Romina Rojas Tessel; Rodolfo Perez Alamino; Marina Laura Werner; Sofía Ornella; Luciana Casalla; Maria de La Vega; María Severina; Mercedes García; Luciana Gonzalez Lucero; Cecilia Romeo; Sebastián Moyano; Tatiana Barbich; Ana Bertoli; Andrea Baños; Sandra Petruzzelli; Carla Matellan; Silvana Conti; Ma. Alicia Lazaro; Gustavo Fabián Rodriguez Gil; Fabian Risueño; Maria Isabel Quaglia; Julia Scafati; Natalia Lili Cuchiaro; Jonathan Eliseo Rebak; Susana Isabel Pineda; María Elena Calvo; Eugenia Picco; Josefina Gallino Yanzi; Pablo Maid; Debora Guaglianone; Julieta Silvana Morbiducci; Sabrina Porta; Natalia Herscovich; José Luis Velasco Zamora; Boris Kisluk; Maria Sol Castaños Menescardi; Rosana Gallo; María Victoria Martire; Carla Maldini; Cecilia Goizueta; Sabrina Solange de La Vega Fernandez; Carolina Aeschlimann; Gisela Subils; Sebastián Ibáñez; Anne-Marie Chassin-Trubert; Lingli Dong; Lui Cajas; Marko Barešic; Branimir Anic; Melanie-Ivana Culo; Tea Ahel Pavelic; Kristina Kovacevic Stranski; Boris Karanovic; Jiri Vencovsky; Marta Píchová; Maria Filkova; Hesham Hamoud; Dimitrios Vassilopoulos; Gabriela Maria Guzman Melgar; Ho So; Márta Király; Mahdi Vojdanian; Alexandra Balbir-Gurman; Fatemah Abutiban; Julija Zepa; Inita Bulina; Loreta Bukauskiene; Beatriz Zaueta; Angel Alejandro Castillo Ortiz; Erick Zamora Tehozol; David Vega; Diana Cervántes Rosete; Eduardo Martín Nares; Tatiana Sofia Rodriguez-Reyna; Marina Rull Gabayet; Deshiré Alpízar-Rodríguez; Fedra Irazoque; Xochitl Jimenez; Lenny Geurts-van Bon; Theo Zijlstra; Monique Hoekstra; Nasra Al-Adhoubi; Babur Salim; Enrique Giraldo; Ariel Salinas; Jaroslaw Nowakowski; Rachael Flood; Geraldine Mccarthy; Ioana Felea; Ileana Filipescu; Simona Rednic; Laura Groseanu; Maria Magdelena Tamas; Vanda Mlynarikova; Martina Skamlova; Martin Zlnay; Dagmar Miceková; Lubica Capova; Zelmira Macejova; Emoke Štenová; Helena Raffayova; Gabriela Belakova; Eva Strakova; Marieta Sencarová; Sona Žlnayová; Anna Anna Sabová; Daniela Spisakova; Mária Oetterová; Olga Lukacova; Martina Bakosova; Alojzija Hocevar; Natalia de La Torre-Rubio; Juan José Alegre Sancho; Montserrat Corteguera Coro; Juan Carlos Cobeta Garcia; Maria Carmen Torres Martin; Jose Campos; Jose Gomez Puerta; Gozd Kubra Yardimci; Servet Akar; Ozan Cemal Icacan; Selda Çelik; Viktoriia Vasylets; Su-Ann Yeoh; Claire Vandevelde; Sasha Dunt; Jane Leeder; Elizabeth Macphie; Rosaria Salerno; Christine Graver; Katie Williams; Sheila O'Reilly; Kirsty Devine; Jennifer Tyler; Elizabeth Warner; James Pilcher; Samir Patel; Elena Nikiphorou; Laura Chadwick; Caroline Mulvaney Jones; Beverley Harrison; Lucy Thornton; Diana O'Kane; Lucia Fusi; Audrey Low; Sarah Horton; Shraddha Jatwani; Sara Baig; Hammad Bajwa; Vernon Berglund; Angela Dahle; Walter Dorman; Jody Hargrove; Maren Hilton; Nicholas Lebedoff; Susan Leonard; Jennifer Morgan; Emily Pfeifer; Archibald Skemp; Jeffrey Wilson; Anne Wolff; Eduardo Cepeda; Tiffany Hsu; Derrick Todd; Denise Hare; Cassandra Calabrese; Christopher Adams; Arezou Khosroshahi; Adam Kilian; Douglas White; Melanie Winter; Theodore Fields; Caroline Siegel; Nicole Daver; Melissa Harvey; Neil Kramer; Concetta Lamore; Suneya Hogarty; Karen Yeter; Faizah Siddique; Byung Ban; Tamar Tanner; Eric Ruderman; William Davis; Robert Quinet; Evangeline Scopelitis; Karen Toribio Toribio; Tameka Webb-Detiege; Jerald Zakem; Khurram Abbass; Gilbert Kepecs; Lilliam Miranda; Michael Guma; Ammar Haikal; Sushama Mody; Daric Mueller; Arundathi Jayatilleke; Joann Zell; Alison Bays; Kathryn Dao; Ezzati Fatemeh; Deborah Parks; David Karp; Guillermo Quiceno

doi:10.1016/S2665-9913(21)00316-7

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Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

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Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Sebastian Sattui, Richard Conway, Michael Putman, Andrea Seet, Milena Gianfrancesco, Kaley Beins, Catherine Hill, David Liew, Sarah Mackie, Puja Mehta, …

The Lancet Rheumatology, Vol.3(12), pp.e855-e864

12/2021

DOI: https://doi.org/10.1016/S2665-9913(21)00316-7

PMCID: PMC8570701

PMID: 34778843

Abstract

Background: Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.Methods: In this retrospective cohort study, adult patients (aged ≥18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behçet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.Findings: Of 1202 eligible patients identified in the registry, 733 (61·0%) were women and 469 (39·0%) were men, and their mean age was 63·8 years (SD 17·1). A total of 374 (31·1%) patients had polymyalgia rheumatica, 353 (29·4%) had ANCA-associated vasculitis, 183 (15·2%) had giant cell arteritis, 112 (9·3%) had Behçet's syndrome, and 180 (15·0%) had other vasculitis. Of 1020 (84·9%) patients with outcome data, 512 (50·2%) were not hospitalised, 114 (11·2%) were hospitalised and did not receive supplemental oxygen, 239 (23·4%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15·2%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1·44 [95% CI 1·31-1·57]), were male compared with female (1·38 [1·05-1·80]), had more comorbidities (per each additional comorbidity 1·39 [1·23-1·58]), were taking 10 mg/day or more of prednisolone compared with none (2·14 [1·50-3·04]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2·12 [1·49-3·02]). Risk factors varied among different disease subtypes.Interpretation: Among patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.

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Title: Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study
Creators - without role: Sebastian Sattui - University of Pittsburgh
Richard Conway - St. James's Hospital
Michael Putman - Medical College of Wisconsin
Andrea Seet - University of California, San Francisco
Milena Gianfrancesco - University of California, San Francisco
Kaley Beins - Vasculitis Foundation
Catherine Hill - Queen Elizabeth Hospital
David Liew - Austin Health
Sarah Mackie - University of Leeds
Puja Mehta - University College London Hospitals NHS Foundation Trust
Lorna Neill
Gimena Gomez - Argentine Water and Sanitation
Maria Isabel Haye Salinas - National University of La Rioja
Federico Nicolas Maldonado - Helios Salud
Henrique Ataide Mariz - Universidade Federal de Pernambuco
Samia Araujo de Sousa Studart - Hospital Geral de Fortaleza
Nafice Costa Araujo - Hospital do Servidor Público Estadual
Ann Knight - Uppsala University
Davide Rozza - Società Italiana di Reumatologia
Luca Quartuccio - University of Udine
Maxime Samson - Maison des Sciences de l’Homme de Dijon
Stéphane Bally - Centre Hospitalier Métropole Savoie
Alexandre Tj Maria - Centre Hospitalier Universitaire de Montpellier
Pascal Chazerain - Groupe Hospitalier Diaconesses Croix Saint-Simon
Rebecca Hasseli - University of Giessen
Ulf Müller-Ladner - University of Giessen
Bimba Hoyer - University Hospital Schleswig-Holstein
Reinhard Voll - University of Freiburg
Rita Pinheiro Torres - Universidade Nova de Lisboa
Mariana Luis - University of Coimbra
Sandra Lucia Euzebio Ribeirio - Universidade Federal do Amazonas
Samar Al-Emadi - Hamad Medical Corporation
Jeffrey Sparks - Brigham and Women's Hospital
Tiffany Y-T Hsu - Brigham and Women's Hospital
Kristin d'Silva - Massachusetts General Hospital
Naomi Patel - Massachusetts General Hospital
Leanna Wise - Los Angeles Medical Center
Emily Gilbert - Mayo Clinic Health System
Maria Valenzuela Almada - Mayo Clinic Health System
Alí Duarte-García - Mayo Clinic Health System
Manuel Ugarte-Gil - Universidad Científica del Sur
Lindsay Jacobsohn - University of California, San Francisco
Zara Izadi - University of California, San Francisco
Anja Strangfeld - German Rheumatism Research Centre
Elsa Mateus - Portuguese League Against Epilepsy
Kimme Hyrich - Massachusetts General Hospital
Laure Gossec - Sorbonne Université
Loreto Carmona - Instituto de Salud Musculoesquelética
Saskia Lawson-Tovey - Manchester Academic Health Science Centre
Lianne Kearsley-Fleet - Versus Arthritis
Martin Schaefer - German Rheumatism Research Centre
Emily Sirotich - McMaster University
Jonathan Hausmann - Boston Children's Hospital
Paul Sufka - HealthPartners
Suleman Bhana - Crystal Run Healthcare
Jean Liew - Boston University School of Medicine
Rebecca Grainger - University of Otago
Pedro Machado - London North West Healthcare NHS Trust
Zachary Wallace - Harvard University
Jinoos Yazdany - University of California, San Francisco
Philip Robinson - University of Queensland
Brahim Dahou
Eva Rath
Yves Piette
Mieke Devinck
Bea Maeyaert
Francinne Machado Ribeiro
Sandra Lucia Euzebio Ribeiro
Marcelo Pinheiro
Rosana Quintana
Karen Roberts
Roberto Miguel Baez
Vanessa Castro Coello
María Haye Salinas
Alvaro Andres Reyes Torres
Gelsomina Alle
Romina Tanten
Hernán Maldonado Ficco
Romina Nieto
Carla Gobbi
Yohana Tissera
Cecilia Pisoni
Alba Paula
Juan Alejandro Albiero
Maria Marcela Schmid
Micaela Cosatti
Maria Julieta Gamba
Carlevaris Leandro
María Alejandra Cusa
Noelia German
Veronica Bellomio
Lorena Takashima
Mariana Pera
Karina Cogo
Maria Soledad Gálvez Elkin
María Alejandra Medina
Veronica Savio
Ivana Romina Rojas Tessel
Rodolfo Perez Alamino
Marina Laura Werner
Sofía Ornella
Luciana Casalla
Maria de La Vega
María Severina
Mercedes García
Luciana Gonzalez Lucero
Cecilia Romeo
Sebastián Moyano
Tatiana Barbich
Ana Bertoli
Andrea Baños
Sandra Petruzzelli
Carla Matellan
Silvana Conti
Ma. Alicia Lazaro
Gustavo Fabián Rodriguez Gil
Fabian Risueño
Maria Isabel Quaglia
Julia Scafati
Natalia Lili Cuchiaro
Jonathan Eliseo Rebak
Susana Isabel Pineda
María Elena Calvo
Eugenia Picco
Josefina Gallino Yanzi
Pablo Maid
Debora Guaglianone
Julieta Silvana Morbiducci
Sabrina Porta
Natalia Herscovich
José Luis Velasco Zamora
Boris Kisluk
Maria Sol Castaños Menescardi
Rosana Gallo
María Victoria Martire
Carla Maldini
Cecilia Goizueta
Sabrina Solange de La Vega Fernandez
Carolina Aeschlimann
Gisela Subils
Sebastián Ibáñez
Anne-Marie Chassin-Trubert
Lingli Dong
Lui Cajas
Marko Barešic
Branimir Anic
Melanie-Ivana Culo
Tea Ahel Pavelic
Kristina Kovacevic Stranski
Boris Karanovic
Jiri Vencovsky
Marta Píchová
Maria Filkova
Hesham Hamoud
Dimitrios Vassilopoulos
Gabriela Maria Guzman Melgar
Ho So - University of California, San Francisco
Márta Király
Mahdi Vojdanian
Alexandra Balbir-Gurman
Fatemah Abutiban
Julija Zepa
Inita Bulina
Loreta Bukauskiene
Beatriz Zaueta
Angel Alejandro Castillo Ortiz
Erick Zamora Tehozol
David Vega
Diana Cervántes Rosete
Eduardo Martín Nares
Tatiana Sofia Rodriguez-Reyna
Marina Rull Gabayet
Deshiré Alpízar-Rodríguez
Fedra Irazoque
Xochitl Jimenez
Lenny Geurts-van Bon
Theo Zijlstra
Monique Hoekstra
Nasra Al-Adhoubi
Babur Salim
Enrique Giraldo
Ariel Salinas
Jaroslaw Nowakowski
Rachael Flood
Geraldine Mccarthy
Ioana Felea
Ileana Filipescu
Simona Rednic
Laura Groseanu
Maria Magdelena Tamas
Vanda Mlynarikova
Martina Skamlova
Martin Zlnay
Dagmar Miceková
Lubica Capova
Zelmira Macejova
Emoke Štenová
Helena Raffayova
Gabriela Belakova
Eva Strakova
Marieta Sencarová
Sona Žlnayová
Anna Anna Sabová
Daniela Spisakova
Mária Oetterová
Olga Lukacova
Martina Bakosova
Alojzija Hocevar
Natalia de La Torre-Rubio
Juan José Alegre Sancho
Montserrat Corteguera Coro
Juan Carlos Cobeta Garcia
Maria Carmen Torres Martin
Jose Campos
Jose Gomez Puerta
Gozd Kubra Yardimci
Servet Akar
Ozan Cemal Icacan
Selda Çelik
Viktoriia Vasylets
Su-Ann Yeoh
Claire Vandevelde
Sasha Dunt
Jane Leeder
Elizabeth Macphie
Rosaria Salerno
Christine Graver
Katie Williams
Sheila O'Reilly
Kirsty Devine
Jennifer Tyler
Elizabeth Warner
James Pilcher
Samir Patel
Elena Nikiphorou
Laura Chadwick
Caroline Mulvaney Jones
Beverley Harrison
Lucy Thornton
Diana O'Kane
Lucia Fusi
Audrey Low
Sarah Horton
Shraddha Jatwani
Sara Baig
Hammad Bajwa
Vernon Berglund
Angela Dahle
Walter Dorman
Jody Hargrove
Maren Hilton
Nicholas Lebedoff
Susan Leonard
Jennifer Morgan
Emily Pfeifer
Archibald Skemp
Jeffrey Wilson
Anne Wolff
Eduardo Cepeda
Tiffany Hsu - Brigham and Women's Hospital
Derrick Todd
Denise Hare
Cassandra Calabrese
Christopher Adams
Arezou Khosroshahi
Adam Kilian
Douglas White
Melanie Winter
Theodore Fields
Caroline Siegel
Nicole Daver
Melissa Harvey
Neil Kramer
Concetta Lamore
Suneya Hogarty
Karen Yeter
Faizah Siddique
Byung Ban
Tamar Tanner
Eric Ruderman
William Davis
Robert Quinet
Evangeline Scopelitis
Karen Toribio Toribio
Tameka Webb-Detiege
Jerald Zakem
Khurram Abbass
Gilbert Kepecs
Lilliam Miranda
Michael Guma
Ammar Haikal
Sushama Mody
Daric Mueller
Arundathi Jayatilleke
Joann Zell
Alison Bays
Kathryn Dao
Ezzati Fatemeh
Deborah Parks
David Karp
Guillermo Quiceno
Publication Details: The Lancet Rheumatology, Vol.3(12), pp.e855-e864
Identifiers: 9934328109311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Language: English
Resource Type: Journal article
Local Fields: hal-03640587