Outcome of infection with omicron <scp>SARS‐CoV</scp> ‐2 variant in patients with hematological malignancies: An <scp>EPICOVIDEHA</scp> survey report

Ola Blennow; Jon Salmanton-García; Piotr Nowak; Federico Itri; Jaap van Doesum; Alberto López-García; Francesca Farina; Ozren Jaksic; László Imre Pinczés; Yavuz Bilgin; Iker Falces-Romero; Moraima Jiménez; Irati Ormazabal-Vélez; Barbora Weinbergerová; Rémy Duléry; Zlate Stojanoski; Tobias Lahmer; Noemí Fernández; José‐ángel Hernández-Rivas; Verena Petzer; Nick de Jonge; Andreas Glenthøj; Cristina de Ramón; Monika Biernat; Nicola Fracchiolla; Avinash Aujayeb; Jens van Praet; Martin Schönlein; Gustavo‐adolfo Méndez; Chiara Cattaneo; Anna Guidetti; Mariarita Sciumè; Emanuele Ammatuna; Raul Cordoba; Nicole García-Poutón; Stefanie Gräfe; Alba Cabirta; Dominik Wolf; Anna Nordlander; Ramón García-Sanz; Mario Delia; Caroline Berg Venemyr; Clara Brones; Roberta Di Blasi; Elizabeth de Kort; Stef Meers; Sylvain Lamure; Laura Serrano; Maria Merelli; Nicola Coppola; Rui Bergantim; Caroline Besson; Milena Kohn; Jessica Petiti; Carolina Garcia-Vidal; Michelina Dargenio; François Danion; Marina Machado; Rebeca Bailén-Almorox; Martin Hoenigl; Giulia Dragonetti; Louis Yi Ann Chai; Chi Shan Kho; Matteo Bonanni; Raphaël Liévin; Francesco Marchesi; Oliver Cornely; Livio Pagano

doi:10.1002/ajh.26626

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Outcome of infection with omicron <scp>SARS‐CoV</scp> ‐2 variant in patients with hematological malignancies: An <scp>EPICOVIDEHA</scp> survey report

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Outcome of infection with omicron SARS‐CoV ‐2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Ola Blennow, Jon Salmanton-García, Piotr Nowak, Federico Itri, Jaap van Doesum, Alberto López-García, Francesca Farina, Ozren Jaksic, László Imre Pinczés, Yavuz Bilgin, …

American Journal of Hematology, Vol.97(8)

28/06/2022

DOI: https://doi.org/10.1002/ajh.26626

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused high mortality in patients with hematological malignancies (HM). 1 The newly emerged omicron variants of SARS-CoV-2 harbor multiple novel spike protein mutations that raise concerns about vaccine efficiency and antiviral efficacy of the available therapeutic monoclonal antibodies. 2 The first published clinical data in immunocompetent patients have found that infection with omicron variants is associated with reduced vaccine efficiency compared to the delta variants, but decreased hospital admission and mortality. 3,4 Preliminary, prepublished, data from a large case-control study have shown that the vaccine effect against omicron in immunocompromised patients, including HM patients, is even more reduced, but data regarding clinical outcomes are lacking. 5 The aim of this study was to describe risk factors, antiviral treatment and outcomes of SARS-CoV-2 omicron variant infection in 593 HM patients included in the EPICOVIDEHA registry. EPICOVIDEHA is an international open web-based registry for patients with HM infected with SARS-CoV-2. 1,6 Both hospitalized and nonhospitalized patients are eligible for inclusion. The questionnaire includes data on the HM, SARS-CoV-2 vaccination status, risk factors for severe COVID-19 infection, SARS-CoV-2 virus variant, antiviral treatment, and outcomes including mortality (eFigure 1 and eTable 4).

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Title: Outcome of infection with omicron SARS‐CoV ‐2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report
Creators - without role: Ola Blennow - Karolinska University Hospital
Jon Salmanton-García - University Hospital Cologne
Piotr Nowak - Karolinska University Hospital
Federico Itri - Ospedale San Luigi Gonzaga
Jaap van Doesum - University Medical Center Groningen
Alberto López-García - Hospital Universitario Fundación Jiménez Díaz
Francesca Farina - Gruppo Italiano per il Trapianto di Midollo Osseo
Ozren Jaksic - University Hospital Dubrava
László Imre Pinczés - University of Debrecen
Yavuz Bilgin - Admiraal De Ruyter Ziekenhuis
Iker Falces-Romero - Hospital Universitario La Paz
Moraima Jiménez - Vall d'Hebron Hospital Universitari
Irati Ormazabal-Vélez - Complejo Hospitalario de Navarra
Barbora Weinbergerová - Masaryk University
Rémy Duléry - Hôpital Saint-Antoine
Zlate Stojanoski - Saints Cyril and Methodius University of Skopje
Tobias Lahmer - Klinikum rechts der Isar
Noemí Fernández - Marqués de Valdecilla University Hospital
José‐ángel Hernández-Rivas - Hospital Universitario Infanta Leonor
Verena Petzer - Innsbruck Medical University
Nick de Jonge - Amsterdam University Medical Centers
Andreas Glenthøj - Copenhagen University Hospital
Cristina de Ramón - Centro de Investigación del Cáncer
Monika Biernat - Wroclaw Medical University
Nicola Fracchiolla - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Avinash Aujayeb - Northumbria Healthcare NHS Foundation Trust
Jens van Praet - AZ Sint-Jan
Martin Schönlein - University Medical Center Hamburg-Eppendorf
Gustavo‐adolfo Méndez - National University of Misiones
Chiara Cattaneo - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Anna Guidetti - Fondazione IRCCS Istituto Nazionale dei Tumori
Mariarita Sciumè - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Emanuele Ammatuna - University Medical Center Groningen
Raul Cordoba - Hospital Universitario Fundación Jiménez Díaz
Nicole García-Poutón - Universitat de Barcelona
Stefanie Gräfe - University Hospital Cologne
Alba Cabirta - Vall d'Hebron Hospital Universitari
Dominik Wolf
Anna Nordlander - Karolinska University Hospital
Ramón García-Sanz - Instituto de Investigación Biomédica de Salamanca
Mario Delia
Caroline Berg Venemyr
Clara Brones - Centre Hospitalier de Versailles
Roberta Di Blasi - Hôpital Saint-Louis
Elizabeth de Kort - Radboud University Nijmegen
Stef Meers - AZ Klina
Sylvain Lamure - Centre National de la Recherche Scientifique
Laura Serrano
Maria Merelli
Nicola Coppola
Rui Bergantim - Hospital de São João
Caroline Besson - Centre Hospitalier de Versailles
Milena Kohn - Centre Hospitalier de Versailles
Jessica Petiti - University of Turin
Carolina Garcia-Vidal - Hospital Clínic de Barcelona
Michelina Dargenio - Ospedale Vito Fazzi
François Danion
Marina Machado - Hospital General Universitario Gregorio Marañón
Rebeca Bailén-Almorox
Martin Hoenigl - University of California System
Giulia Dragonetti - Agostino Gemelli University Polyclinic
Louis Yi Ann Chai - National University Health System
Chi Shan Kho - Pamela Youde Nethersole Eastern Hospital
Matteo Bonanni - Università Cattolica del Sacro Cuore
Raphaël Liévin - Hôpital Saint-Louis
Francesco Marchesi - Istituti di Ricovero e Cura a Carattere Scientifico
Oliver Cornely - Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Livio Pagano - Agostino Gemelli University Polyclinic
Publication Details: American Journal of Hematology, Vol.97(8)
Identifiers: 9944057309311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-03791162