Résumé
We report the synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives from
N-benzyl-4-piperidone and
N-protected amino acid amides on solid support. We have translated the chemistry from solution to solid phase using a backbone amide linker (BAL) mimic. Using a parallel combinatorial approach, we performed the optimization of the synthesis on SynPhase™ Lanterns.
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