Résumé
Diagnostic criteria of allergic bronchopulmonary aspergillosis have been updated in 2024. The use of molecular fungal allergens could complement these essential criteria for allergic bronchopulmonary aspergillosis to improve its diagnosis. This French pilot study was conducted to determine optimal Aspergillus fumigatus (A. fumigatus)-specific IgE (A. fumigatus-IgE) and molecular allergen (rAsp)-IgE cut-off values in routine practice and to confirmed the allergic bronchopulmonary aspergillosis diagnostic strategy using IgE tests described in medical algorithms. A. fumigatus-IgE and rAsp-IgE showed robust discrimination capabilities between allergic bronchopulmonary aspergillosis and A. fumigatus sensitisation (AUROC >0.80). Their optimal local cutoffs outperformed those recommended, particularly A. fumigatus-IgE (≥2.64 kUA/L) and Asp f1-IgE (≥2.65 kUA/L) and could improve the diagnostic of allergic bronchopulmonary aspergillosis.