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One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst
Article de revue   Avec comité de lecture

One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst

Hassan B. Lazrek, Laila Baddi, Michael Smietana, Jean-Jacques Vasseur, Said Sebti et Mohamed Zahouily
Nucleosides, nucleotides & nucleic acids, Vol.27(10-11), pp.1107-1112
10/2008
DOI: https://doi.org/10.1080/15257770802341285
PMID: 18788041

Résumé

Biochemistry & Molecular Biology Life Sciences & Biomedicine Science & Technology
Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.

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