Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

A. Auperin; R. Obongo; F.R. Ferrand; N. Saroul; F. Janot; S. Albert; G. Andry; E. Babin; C. Bach; J.-M. Badet; C. Badoual; A.C. Baglin; A. Banal; B. Barry; Emmanuel Baudin; B. Baujat; R.J. Bensadoun; C. Bertolus; J.-P. Bessède; D. Blanchard; C. Borel; A. Bozorg-Grayeli; R. Breheret; P. Breton; L. Brugel; G. Calais; O. Casiraghi; E. Cassagnau; L. Castillo; P. Ceruse; F. Chabolle; D. Chevalier; J.C. Chobaut; O. Choussy; A. Cosmidis; A. Coste; V. Costes; L. Crampette; V. Darrouzet; P. Demez; P. Dessi; Bernard Devauchelle; L. Digue; G. Dolivet; F. Dubrulle; S. Duflo; X. Dufour; C. Even; S. Faivre; N. Fakhry; C. Ferron; F. Floret; L. de Gabory; R. Garrel; L. Geoffrois; L. Gilain; A. Giovanni; A. Girod; B. Guerrier; S. Hans; P. Herman; P. Hofman; M. Housset; R. Jankowski; F. Jegoux; M. Juliéron; M.-C. Kaminsky; F. Kolb; J. Lacau St Guily; L. Laccoureye; B. Lallemant; P. Lang; E. Lartigau; J.-P. Lavieille; M. Lefevre; X. Leroy; O. Malard; F. Massip; O. Mauvais; J.-C. Merol; J. Michel; T. Mom; S. Morinière; E. de Mones; G. Moulin; A. Moya-Plana; G. Noël; G. Poissonnet; J.-M. Prades; D. de Raucourt; E. Reyt; C. Righini; Y. Marie Robin; F. Rolland; B. Ruhin; N. Sarroul; P. Schultz; E. Serrano; O. Sterkers; V. Strunski; A. Sudaka; M. Tassart; Sylvie Testelin; J. Thariat; A. Timochenko; B. Toussaint; E. Uro Coste; G. Valette; T. van den Abbeele; A. Varoquaux; F. Veillon; S. Vergez; B. Vérillaud; M. Wassef

doi:10.1016/j.ejca.2019.09.007

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Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

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Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

A. Auperin, R. Obongo, F.R. Ferrand, N. Saroul, F. Janot, S. Albert, G. Andry, E. Babin, C. Bach, J.-M. Badet, …

European Journal of Cancer, Vol.123, pp.1-10

12/2019

DOI: https://doi.org/10.1016/j.ejca.2019.09.007

Résumé

Prognosis

Oral cavity

Sinonasal

Radiotherapy

Head and neck

Mucosal melanoma

Background:Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established.Material & methods:Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed.Results:In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p < 10-4), although, as in SNMM, it was not a significant prognostic predictor.Conclusion:Even early HNMM was associated with poor oncologic outcomes due to distant metastases despite surgical resection with clear margins. Lymph node metastases had no impact on the prognosis, suggesting treatment de-escalation in cervical node management. PORT might be useful for local control.

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Titre: Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France
Créateurs - sans rôle: A. Auperin - Institut Gustave Roussy
R. Obongo - Institut Gustave Roussy
F.R. Ferrand - Hôpital Fernand-Widal
N. Saroul - Centre Hospitalier Universitaire de Clermont-Ferrand
F. Janot - Institut Gustave Roussy
S. Albert - ETH Zurich
G. Andry - Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors
E. Babin - Centre Hospitalier Universitaire de Caen Normandie
C. Bach - Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors
J.-M. Badet
C. Badoual
A.C. Baglin - Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors
A. Banal
B. Barry - Hôpital Bichat-Claude-Bernard
Emmanuel Baudin - Médecine nucléaire
B. Baujat - Sorbonne Université
R.J. Bensadoun
C. Bertolus
J.-P. Bessède
D. Blanchard - Hôpital Pellegrin
C. Borel - Centre Paul Strauss
A. Bozorg-Grayeli
R. Breheret
P. Breton - Hôpital Lariboisière
L. Brugel - Hôpital Pellegrin
G. Calais - Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-.2022]
O. Casiraghi - Institut Gustave Roussy
E. Cassagnau
L. Castillo - Hôpital Pellegrin
P. Ceruse - Hôpital de la Croix-Rousse
F. Chabolle
D. Chevalier - Chambre Régionale d'Agriculture des Pays de la Loire
J.C. Chobaut
O. Choussy - Centre Hospitalier Universitaire de Rouen
A. Cosmidis - Hospices Civils de Lyon
A. Coste - Centre Hospitalier Universitaire de Montpellier
V. Costes - Centre Hospitalier Universitaire de Montpellier
L. Crampette - Université de Montpellier
V. Darrouzet - Service d'ORL
P. Demez - Hôpital Lariboisière
P. Dessi - BIO
Bernard Devauchelle - Centre Hospitalier Universitaire Amiens-Picardie
L. Digue - Hôpital Pellegrin
G. Dolivet - Institut de Cancérologie de Lorraine
F. Dubrulle - Hôpital Claude Huriez
S. Duflo
X. Dufour
C. Even
S. Faivre
N. Fakhry - BIO
C. Ferron - Centre Hospitalier Universitaire de Saint-Étienne
F. Floret - Université Sorbonne Paris Nord
L. de Gabory - Hôpital Pellegrin
R. Garrel - Service ORL et chirurgie cervico faciale [CHU Montpellier]
L. Geoffrois - Institut de Cancérologie de Lorraine
L. Gilain - Hôpital Pellegrin
A. Giovanni - Hôpital de la Timone
A. Girod
B. Guerrier - Fluides, Automatique et Systèmes Thermiques
S. Hans - Laboratoire Géomatériaux
P. Herman - Hôpital Fernand-Widal
P. Hofman - Centre Méditerranéen de Médecine Moléculaire
M. Housset
R. Jankowski - Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHRU Nancy]
F. Jegoux - Centre Hospitalier Universitaire de Rennes
M. Juliéron
M.-C. Kaminsky
F. Kolb
J. Lacau St Guily - Charmo University
L. Laccoureye - Hôpital Pellegrin
B. Lallemant - Centre Hospitalier Universitaire de Nîmes
P. Lang - University of St Andrews
E. Lartigau - Centre Oscar Lambret
J.-P. Lavieille
M. Lefevre
X. Leroy
O. Malard - Centre Hospitalier Universitaire de Nantes
F. Massip - Laboratoire de Biométrie et Biologie Evolutive
O. Mauvais
J.-C. Merol - Université de Reims Champagne-Ardenne
J. Michel - Institut d'Électronique et des Systèmes
T. Mom - Centre François Baclesse
S. Morinière - Centre Hospitalier Universitaire de Tours
E. de Mones - Service d'ORL
G. Moulin - Hôpital Pellegrin
A. Moya-Plana - Institut Gustave Roussy
G. Noël - Université de Rennes
G. Poissonnet - Centre Antoine Lacassagne
J.-M. Prades
D. de Raucourt - Centre Hospitalier Universitaire de Caen Normandie
E. Reyt - Université Grenoble Alpes
C. Righini - Inserm
Y. Marie Robin
F. Rolland - CRLCC René Gauducheau
B. Ruhin
N. Sarroul - Centre Hospitalier Universitaire de Clermont-Ferrand
P. Schultz - Service d'ORL et chirurgie cervico-faciale
E. Serrano
O. Sterkers - Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition
V. Strunski - Hôpital Lariboisière
A. Sudaka
M. Tassart - Hôpital Tenon
Sylvie Testelin - Centre Hospitalier Universitaire Amiens-Picardie
J. Thariat - Centre François Baclesse
A. Timochenko
B. Toussaint
E. Uro Coste
G. Valette - Hôpital Pellegrin
T. van den Abbeele - Centre François Baclesse
A. Varoquaux - Centre de Résonance Magnétique Biologique et Médicale
F. Veillon - Laboratoire de Cristallographie et Sciences des Matériaux
S. Vergez - Hôpital Paule de Viguier
B. Vérillaud - Service d'oto-rhino-laryngologie
M. Wassef - Biomécanique et Bioingénierie
Détails de publication: European Journal of Cancer, Vol.123, pp.1-10
Identifiants: 9933901809311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02548630