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On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition
Journal article   Peer reviewed

On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition

Victor Goncalves, Benoît Gautier, Anne Regazzetti, Pascale Coric, Serge Bouaziz, Christiane Garbay, Michel Vidal and Nicolas Inguimbert
Bioorganic and Medicinal Chemistry Letters, Vol.17(20), pp.5590-5594
10/2007
DOI: https://doi.org/10.1016/j.bmcl.2007.07.087
PMID: 17826090

Abstract

Alkynes Amino Acid Sequence Molecular Sequence Data Peptides Protein Binding Protein Structure, Quaternary Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Azides Catalysis Chromatography, High Pressure Liquid Copper Crystallography, X-Ray Cyclization Ligands Models, Molecular
Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.
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