Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants

Selene Zarate; Blanca Taboada; Mauricio Rosales-Rivera; Rodrigo Garcia-Lopez; Jose Esteban Munoz-Medina; Alejandro Sanchez-Flores; Alfredo Herrera-Estrella; Bruno Gomez-Gil; Nelly Selem Mojica; Angel Gustavo Salas-Lais; Joel Armando Vazquez-Perez; David Alejandro Cabrera-Gaytan; Larissa Fernandes-Matano; Luis Antonio Uribe-Noguez; Juan Bautista Chale-Dzul; Brenda Irasema Maldonado Meza; Fidencio Mejia-Nepomuceno; Rogelio Perez-Padilla; Rosa Maria Gutierrez-Rios; Antonio Loza; Benjamin Roche; Susana Lopez; Carlos F. Arias

doi:10.3390/v15010243

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Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants

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Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants

Selene Zarate, Blanca Taboada, Mauricio Rosales-Rivera, Rodrigo Garcia-Lopez, Jose Esteban Munoz-Medina, Alejandro Sanchez-Flores, Alfredo Herrera-Estrella, Bruno Gomez-Gil, Nelly Selem Mojica, Angel Gustavo Salas-Lais, …

Viruses, Vol.15(1), p.243

15/01/2023

DOI: https://doi.org/10.3390/v15010243

PMID: 36680283

Résumé

Life Sciences & Biomedicine

Science & Technology

Virology

Purpose: The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In this work, a characterization of the spread of this variant in Mexico is presented. Methods: The time to fixation of BA.1, the diversity of Delta sublineages, the population density, and the level of virus circulation during the inter-wave interval were determined to analyze differences in BA.1 spread. Results: BA.1 began spreading during the first week of December 2021 and became dominant in the next three weeks, causing the fourth COVID-19 epidemiological surge in Mexico. Unlike previous variants, BA.1 did not exhibit a geographically distinct circulation pattern. However, a regional difference in the speed of the replacement of the Delta variant was observed. Conclusions: Viral diversity and the relative abundance of the virus in a particular area around the time of the introduction of a new lineage seem to have influenced the spread dynamics, in addition to population density. Nonetheless, if there is a significant difference in the fitness of the variants, or if the time allowed for the competition is sufficiently long, it seems the fitter virus will eventually become dominant, as observed in the eventual dominance of the BA.1.x variant in Mexico.

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Titre: Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
Créateurs - sans rôle: Selene Zarate - Univ Autonoma Ciudad Mexico, Posgrad Ciencias Gen, Mexico City 03100, Mexico
Blanca Taboada - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Mauricio Rosales-Rivera - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Rodrigo Garcia-Lopez - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Jose Esteban Munoz-Medina - Inst Mexicano Seguro Social, Coordinac Cal Insumos & Labs Especializados, Mexico City 07760, Mexico
Alejandro Sanchez-Flores - Univ Nacl Autonoma Mexico, Unidad Univ Secuenciac Mas & Bioinformat, Inst Biotecnol, Cuernavaca 62210, Mexico
Alfredo Herrera-Estrella - Ctr Invest & Estudios Avanzados IPN, Unidad Gen Avanzada, Lab Nacl Gen Biodivers, Irapuato 36821, Mexico
Bruno Gomez-Gil - Ctr Invest Alimentac & Desarrollo AC, Coordinac Reg Mazatlan Acuicultura & Manejo Ambie, Mazatlan 82100, Mexico
Nelly Selem Mojica - Univ Nacl Autonoma Mexico, Ctr Ciencias Matemat, Morelia 58089, Mexico
Angel Gustavo Salas-Lais - Inst Mexicano Seguro Social, Coordinac Cal Insumos & Labs Especializados, Mexico City 07760, Mexico
Joel Armando Vazquez-Perez - Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Tabaquismo & EPOC, Mexico City 14080, Mexico
David Alejandro Cabrera-Gaytan - Inst Mexicano Seguro Social, Coordinac Cal Insumos & Labs Especializados, Mexico City 07760, Mexico
Larissa Fernandes-Matano - Inst Mexicano Seguro Social, Coordinac Cal Insumos & Labs Especializados, Mexico City 07760, Mexico
Luis Antonio Uribe-Noguez - Inst Mexicano Seguro Social, Lab Cent Epidemiol, Mexico City 02990, Mexico
Juan Bautista Chale-Dzul - Inst Mexicano Seguro Social, Unidad Invest Med Yucatan, Merida 97150, Mexico
Brenda Irasema Maldonado Meza - Inst Mexicano Seguro Social, Ctr Invest Biomed Noreste, Monterrey 64720, Mexico
Fidencio Mejia-Nepomuceno - Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Tabaquismo & EPOC, Mexico City 14080, Mexico
Rogelio Perez-Padilla - Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Tabaquismo & EPOC, Mexico City 14080, Mexico
Rosa Maria Gutierrez-Rios - Univ Nacl Autonoma Mexico, Dept Microbiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Antonio Loza - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Benjamin Roche - Univ Montpellier, Infect Dis Vector Control Genet Ecol & Evolut MIV, IRD,CNRS, F-34090 Montpellier, France
Susana Lopez - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Carlos F. Arias - Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Détails de publication: Viruses, Vol.15(1), p.243
Éditeur: Mdpi
Nombre de pages: 14
Note de subvention: national epidemiological surveillance system of Mexico PP-F003 / National Council for Science and Technology-Mexico-CONACyT; Consejo Nacional de Ciencia y Tecnologia (CONACyT) AHF Global Public Health Institute BB/P027849/1 / UKRI; UK Research & Innovation (UKRI) ECTZ184596 / Agence Nationale de Recherche sur le Sida et les Hepatites Virales (ANRS); ANRS; Agence Nationale de la Recherche (ANR) ANRS0138 / ANRS; Agence Nationale de la Recherche (ANR) 1000/023/2021; C-08/2021 / CONACYT; Consejo Nacional de Ciencia y Tecnologia (CONACyT)
Identifiants: 99159099609311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article