Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

John R Teerlink; Rafael Diaz; G. Michael Felker; John J.V McMurray; Marco Metra; Scott D Solomon; Kirkwood F Adams; Inder Anand; Alexandra Arias-Mendoza; Tor Biering-Sørensen; Michael Böhm; Diana Bonderman; John G.F Cleland; Ramon Corbalan; Maria G Crespo-Leiro; Ulf Dahlström; Luis E Echeverria Correa; James C Fang; Gerasimos Filippatos; Cândida Fonseca; Eva Goncalvesova; Assen R Goudev; Jonathan G Howlett; David E Lanfear; Mayanna Lund; Peter Macdonald; Vyacheslav Mareev; Shin‐ichi Momomura; Eileen O'Meara; Alexander Parkhomenko; Piotr Ponikowski; Felix J. A Ramires; Pranas Serpytis; Karen Sliwa; Jindrich Spinar; Thomas M Suter; Janos Tomcsanyi; Hans Vandekerckhove; Dragos Vinereanu; Adriaan A Voors; Mehmet B Yilmaz; Faiez Zannad; Lucie Sharpsten; Jason C Legg; Siddique A Abbasi; Claire Varin; Fady I Malik; Christopher E Kurtz; Diego Alejandro Besada; Claudio Rodolfo Majul; Marco Raul Litvak Bruno; Sonia Sassone; Horacio Alberto Avaca; Mariela Rasmussen; Jorge Roberto Aiub; Miguel Angel Hominal; Eduardo Perna; Ruben Omar Garcia Duran; Lilia Schiavi; Lilia Luz Lobo Marquez; Oscar Alberto Gomez Vilamajo; Ignacio Mackinnon; Ricardo Alfonso Leon Fuente; Oscar Romano Montana; Leonardo Novaretto; Rodolfo Andres Ahuad Guerrero; Daniela Garcia Brasca; Aldo Prado; Marcelo Alejandro Garrido; Hugo Luquez; Diego Felipe Martinez; Liliana Nicolosi; Maria Leonor Parody; Cesar Zaidman; Fernando Colombo Berra; Julio Ibañez; Gerardo Zapata; Alberto Caccavo; Roberto Colque; Mirta Diez; Carlos Poy; Oscar Alejandro Salomone; Daniel Vogel; Anselmo Paulino Bordonava; Alberto Fernandez; John French; John Atherton; Andrew Hamilton; Alistair Begg; Walter Abhayaratna; Christopher Judkins; Carmine De Pasquale; Scott McKenzie; John Amerena; Gregory Szto; Leighton Kearney; Hendrik Zimmet; Aaron Sverdlov; John Beltrame; Dariusz Korczyk; Andrew Sindone; Deddo Moertl; Kurt Huber; Martin Huelsmann; Klemens Ablasser; Christian Ebner; Peter Siostrzonek; Heinz Drexel; Gerhard Poelzl; Karl Dujardin; Matthias Dupont; Ian Buysschaert; Patrizio Lancellotti; Walter Droogne; Iman Chouchane; Fabio Silveira; Salvador Rassi; Gilmar Reis; Pedro Pimentel Filho; Marcus Vinicius Simoes; Joao Carlos Braga; Flavio Eduardo Giorgeto; Almir Ferraz; Cristiano Pederneiras Jaeger; Jose Francisco Saraiva; Alexandre Tognon; Juliano Cardoso; Oswaldo Greco; Maria Sanali Paiva; Bruno Paolino; Otavio Coelho Filho; Lilia Nigro Maia; Rodrigo Silva; Manoel Canesin; Paulo Roberto Ferreira Rossi; Jose Augusto Ribas Fortes; Rodrigo Julio Cerci; Euler Roberto Fernandes Manenti; Paulo Ernesto Leaes; Luis Beck Silva Neto; Weimar Kunz Barroso Souza; Fernando Bacal; Renato Chaves; Felix Ramires; Maria Helena Vidotti; Pedro Gabriel Melo Barros e Silva; Leopoldo Soares Piegas; Georgi Todorov; Maria Tzekova; Assen Goudev; Valentina Mincheva; Ivaylo Vasilev; Snezhanka Tisheva- Gospodinova; Ivo Petrov; Arman Postadzhiyan; Chavdar Velikov; Bojidar Dimov; Christian Constance; Denis‐Carl Phaneuf; Lisa Mielniczuk; A Shekhar Pandey; Manohara Senaratne; Shelley Zieroth; Daniel Savard; Robert Stewart; Thao Huynh; Nadia Giannetti; Gordon Moe; Ronald Bourgeois; Justin Ezekowitz; Michael Hartleib; Bruce Sussex; Mohan Babapulle; Raja Chehayeb; Daniel Gaudet; Robert McKelvie; Viviane Nguyen; Sherryn Roth; Milan Gupta; Yves Pesant; Dennis Rupka; Rakesh Bhargava; Atilio Costa-Vitali; Guy Proulx; Mario Vega; Sergio Potthoff; Maria Cristina Schnettler Cid; Alex Mauricio Villablanca Sepulveda; Fernando Tomas Lanas Zanetti; Victor Areli Saavedra Gajardo; Carlos Conejeros Kindel; Christian Paolo Pincetti Jofre; Jorge Leonardo Cobos Segarra; Manuel Eduardo Rodriguez Venegas; Mario Yanez Hidalgo; Margarita Gertrudis Vejar Jalaf; Weimin Li; Jinguo Zhang; Xin Fu; Xuelian Zhang; Dongye Li; Zhifang Wang; Yanling Qu; Zhe Zheng; Huifang Tang; Ping Yang; Yuhui Zhang; Yang Zheng; Yafei Mi; He Huang; Peili Bu; Guoqin Chen; Jiyan Chen; Yajun Han; Zhangquan Li; Shumei Ma; Xuming Yang; Zuyi Yuan; Yugang Dong; Zhaoping Li; Ailiman Mahemuti; Wentang Niu; Zhenyu Yang; Yuqing Zhang; Yuemin Sun; Weiheng Wu; Feng Liu; Jing Yan; Yinjun Li; Yi Wang; Shouyan Zhang; Changyong Zhou; Hanbin Cui; Jianjun Li; Tianfa Li; Qinghua Han; Yu Wei; Luis Eduardo Echeverria Correa; Jose Luis Accini Mendoza; Fernando Manzur Jattin; Wilder Castaño Osorio; Carlos Alberto Luengas; Julian Alonso Coronel Arroyo; Miguel Alfredo Moncada Corredor; Clara Ines Saldarriaga Giraldo; Rodrigo Botero Lopez; Dora Ines Molina Salazar; Miguel Urina Triana; Luis Horacio Atehortua Lopez; Pastor Olaya Rojas; Sebastian Velez Pelaez; Monica Lopez Pareja; 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Guillermo Antonio Llamas Esperon; Eduardo Salcido Vazquez; Ricardo Garcia Gonzalez; Jose Luis Arenas Leon; Salvador Leon Gonzalez; Maria Alexandra Arias Mendoza; Alicia Contreras Rodriguez; Gustavo Francisco Mendez Machado; Melchor Alpizar Salazar; Alberto Esteban Bazzoni Ruiz; Ana Maria De Leon Flores; Jose Alfredo Pagola Carrasco; Raul Reyes Araiza; Tjeerd Römer; Johannes Remmen; Jacob Van Eck; Arif Elvan; Tom Smilde; Adriaan Voors; Ruud Wal; Jeroen Schaap; Aize Sluis; Gerardus Linssen; Michael Magro; Frank Willems; John Hal; Coenraad Zwaan; Driek Beelen; Dirk Boswijk; Walter Hermans; Henricus Van Kesteren; Russell Scott; Hamish Hart; Marianne Lund; Marcin Szczasny; Tomasz Blicharski; Mariusz Kafara; Anna Stankiewicz; Grzegorz Skonieczny; Maciej Zabowka; Grzegorz Kania; Jerzy Kopaczewski; Lidia Pawlowicz; Janusz Spyra; Aleksander Wlodarczyk; Ryszard Sciborski; Pawel Balsam; Jaroslaw Drozdz; Bozena Sobkowicz; Malgorzata Konieczynska; Malgorzata Lelonek; Zbigniew Bednarkiewicz; Jaroslaw Trebacz; 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Javier Segovia Cubero; Vicente Eduardo Climent Paya; Alejandro Recio Mayoral; Luis Fuente Galan; Juan Jose Gomez Doblas; Ramon Bover Freire; Maria Teresa Blasco Peiro; Beatriz Diaz Molina; Laura Jordan Martinez; Francisco Gonzalez Vilchez; Kurt Boman; Patric Karlstrom; Stefan Berglund; Barna Szabo; Magnus Peterson; Peter Wodlin; Carl‐Johan Lindholm; Tiziano Moccetti; Christian Mueller; Thomas Suter; Roger Hullin; Philippe Meyer; Georg Noll; Zerrin Yigit; Okan Onur Turgut; Lutfu Bekar; Tayfun Sahin; Zehra Lale Koldas; Ahmet Celik; Yuksel Cavusoglu; Mesut Demir; Ersel Onrat; Mehmet Duzenli; Kahraman Cosansu; Ibrahim Haldun Muderrisoglu; Mustafa Tuncer; Ozer Badak; Sanem Nalbantgil; Cevat Kirma; Ertugrul Okuyan; Umit Guray; Oleksandr Prokhorov; Oleksandr Karpenko; Igor Vakaliuk; Andriy Yagensky; Igor Kracz; Mykola Stanislavchuk; Oleksii Kulynych; Mykola Rishko; Roman Stets; Vira Tseluyko; Larysa Mishchenko; Leonid Rudenko; Iurii Rudyk; Liudmyla Alieksieieva; Oleksii Korzh; Yuriy Mostovoy; 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Theodore Takata; Barry Bertolet; Brian Bostick; Andrew Civitello; John Collins; Nabil Dib; James Fang; Richard Gilmore; Wayne Gray; Luanda Grazette; Tariq Haddad; Steven Hearne; Munir Janmohamed; Richard Katz; Navid Kazemi; Sara Llerena; Nicole Lohr; George Marzouka; John Mignone; Henry Ooi; Anna Paszczuk; Christopher Pickett; Gregory Sampognaro; Douglas Sawyer; Steven Shayani; Charles Treasure; Garth Vaz; Nampalli Vijay; Celeste Williams; Gary Yeoman; Lily Zhang; Keith Aaronson; Wael Abo-Auda; Rami Alharethi; William Anderson; Mehrdad Ariani; Sourin Banerji; Paramdeep Baweja; Peter Carson; Arthur Eberly; James Elliott; Ronald Fernando; Daniel Fisher; Steven Forman; George Gabriel; Harinder Gogia; Craig Hametz; Brian Houston; Hassan Ibrahim; Farid Jadbabaie; Christos Kassiotis; Arun Krishnamoorthy; Michael Kwan; Steven Lupovitch; Leonardo Macias; Adnan Malik; Luis Martinez; Michael Miyamoto; Freny Mody; Devesh Patel; Brenda Peart; Barbara Pisani; Mark Ramos; Mariel Rivero; Anil Shah; Mukesh Sharma; Tina Sichrovsky; Marc Simon; Deovrat Singh; Julio Tallet; Christopher Vaccari; Mario Villoch; Matthew Wheeler; Kabir Yousuf; Rafik Abadier; Shuaib Abdullah; Raveen Arora; Shamaila Aslam; Robert Buynak; David Chang; Johanna Contreras; Stephen Halpern; Franklin Handel; John Heitner; William Herzog; Bruce Jackson; John Kao; Nicholas Kondo; Michael Koren; Martin LeWinter; Jeffrey Martindale; Joaquin Martinez-Arraras; Stephanie Olsen; Marek Piatek; Nandkishore Ranadive; William Randall; Sunder Rao; David Rawitscher; James Rider; George Sokos; J Russell Strader; Nasir Sulemanjee; Naeem Tahirkheli; Benjamin Trichon; Thomas Vanhecke; David Whellan; Mohammad Abuannadi; Gaurav Aggarwala; Saad Ahmad; Andre Artis; Jorge Cheirif; Vladimir Cotarlan; Jeremy Cox; Charles Eaton; Viorel Florea; Theodore Frank; Keith Friedman; Vedampattu Ganeshram; Alan Gass; Anthony Gemignani; Syed Hasni; Chester Hedgepeth; Dipti Itchhaporia; Edo Kaluski; Amin Karim; Alan Kono; Ellis Lader; Batlagundu Lakshminarayanan; Neil Lewis; Vinay Malhotra; Nolan Mayer; Robert Mohapatra; Nandini Nair; Terrence O'Brien; Sunil Pauwaa; Christopher Rowan; Sanjeev Saxena; Arnold Seto; Nishant Shah; Pradeep Singh; Hal Skopicki; Marcus Stoddard; Nancy Sweitzer

doi:10.1002/ejhf.2015

$Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials$

Article de revue

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

John R Teerlink, Rafael Diaz, G. Michael Felker, John J.V McMurray, Marco Metra, Scott D Solomon, Kirkwood F Adams, Inder Anand, Alexandra Arias-Mendoza, Tor Biering-Sørensen, …

11/2020

DOI: https://doi.org/10.1002/ejhf.2015

Résumé

R Medicine (General)

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation.

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Titre: Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
Créateurs - sans rôle: John R Teerlink
Rafael Diaz
G. Michael Felker
John J.V McMurray
Marco Metra
Scott D Solomon
Kirkwood F Adams
Inder Anand
Alexandra Arias-Mendoza
Tor Biering-Sørensen
Michael Böhm
Diana Bonderman
John G.F Cleland
Ramon Corbalan
Maria G Crespo-Leiro
Ulf Dahlström
Luis E Echeverria Correa
James C Fang
Gerasimos Filippatos
Cândida Fonseca
Eva Goncalvesova
Assen R Goudev
Jonathan G Howlett
David E Lanfear
Mayanna Lund
Peter Macdonald
Vyacheslav Mareev
Shin‐ichi Momomura
Eileen O'Meara
Alexander Parkhomenko
Piotr Ponikowski
Felix J. A Ramires
Pranas Serpytis
Karen Sliwa
Jindrich Spinar
Thomas M Suter
Janos Tomcsanyi
Hans Vandekerckhove
Dragos Vinereanu
Adriaan A Voors
Mehmet B Yilmaz
Faiez Zannad
Lucie Sharpsten
Jason C Legg
Siddique A Abbasi
Claire Varin
Fady I Malik
Christopher E Kurtz
Diego Alejandro Besada
Claudio Rodolfo Majul
Marco Raul Litvak Bruno
Sonia Sassone
Horacio Alberto Avaca
Mariela Rasmussen
Jorge Roberto Aiub
Miguel Angel Hominal
Eduardo Perna
Ruben Omar Garcia Duran
Lilia Schiavi
Lilia Luz Lobo Marquez
Oscar Alberto Gomez Vilamajo
Ignacio Mackinnon
Ricardo Alfonso Leon Fuente
Oscar Romano Montana
Leonardo Novaretto
Rodolfo Andres Ahuad Guerrero
Daniela Garcia Brasca
Aldo Prado
Marcelo Alejandro Garrido
Hugo Luquez
Diego Felipe Martinez
Liliana Nicolosi
Maria Leonor Parody
Cesar Zaidman
Fernando Colombo Berra
Julio Ibañez
Gerardo Zapata
Alberto Caccavo
Roberto Colque
Mirta Diez
Carlos Poy
Oscar Alejandro Salomone
Daniel Vogel
Anselmo Paulino Bordonava
Alberto Fernandez
John French
John Atherton
Andrew Hamilton
Alistair Begg
Walter Abhayaratna
Christopher Judkins
Carmine De Pasquale
Scott McKenzie
John Amerena
Gregory Szto
Leighton Kearney
Hendrik Zimmet
Aaron Sverdlov
John Beltrame
Dariusz Korczyk
Andrew Sindone
Deddo Moertl
Kurt Huber
Martin Huelsmann
Klemens Ablasser
Christian Ebner
Peter Siostrzonek
Heinz Drexel
Gerhard Poelzl
Karl Dujardin
Matthias Dupont
Ian Buysschaert
Patrizio Lancellotti
Walter Droogne
Iman Chouchane
Fabio Silveira
Salvador Rassi
Gilmar Reis
Pedro Pimentel Filho
Marcus Vinicius Simoes
Joao Carlos Braga
Flavio Eduardo Giorgeto
Almir Ferraz
Cristiano Pederneiras Jaeger
Jose Francisco Saraiva
Alexandre Tognon
Juliano Cardoso
Oswaldo Greco
Maria Sanali Paiva
Bruno Paolino
Otavio Coelho Filho
Lilia Nigro Maia
Rodrigo Silva
Manoel Canesin
Paulo Roberto Ferreira Rossi
Jose Augusto Ribas Fortes
Rodrigo Julio Cerci
Euler Roberto Fernandes Manenti
Paulo Ernesto Leaes
Luis Beck Silva Neto
Weimar Kunz Barroso Souza
Fernando Bacal
Renato Chaves
Felix Ramires
Maria Helena Vidotti
Pedro Gabriel Melo Barros e Silva
Leopoldo Soares Piegas
Georgi Todorov
Maria Tzekova
Assen Goudev
Valentina Mincheva
Ivaylo Vasilev
Snezhanka Tisheva- Gospodinova
Ivo Petrov
Arman Postadzhiyan
Chavdar Velikov
Bojidar Dimov
Christian Constance
Denis‐Carl Phaneuf
Lisa Mielniczuk
A Shekhar Pandey
Manohara Senaratne
Shelley Zieroth
Daniel Savard
Robert Stewart
Thao Huynh
Nadia Giannetti
Gordon Moe
Ronald Bourgeois
Justin Ezekowitz
Michael Hartleib
Bruce Sussex
Mohan Babapulle
Raja Chehayeb
Daniel Gaudet
Robert McKelvie
Viviane Nguyen
Sherryn Roth
Milan Gupta
Yves Pesant
Dennis Rupka
Rakesh Bhargava
Atilio Costa-Vitali
Guy Proulx
Mario Vega
Sergio Potthoff
Maria Cristina Schnettler Cid
Alex Mauricio Villablanca Sepulveda
Fernando Tomas Lanas Zanetti
Victor Areli Saavedra Gajardo
Carlos Conejeros Kindel
Christian Paolo Pincetti Jofre
Jorge Leonardo Cobos Segarra
Manuel Eduardo Rodriguez Venegas
Mario Yanez Hidalgo
Margarita Gertrudis Vejar Jalaf
Weimin Li
Jinguo Zhang
Xin Fu
Xuelian Zhang
Dongye Li
Zhifang Wang
Yanling Qu
Zhe Zheng
Huifang Tang
Ping Yang
Yuhui Zhang
Yang Zheng
Yafei Mi
He Huang
Peili Bu
Guoqin Chen
Jiyan Chen
Yajun Han
Zhangquan Li
Shumei Ma
Xuming Yang
Zuyi Yuan
Yugang Dong
Zhaoping Li
Ailiman Mahemuti
Wentang Niu
Zhenyu Yang
Yuqing Zhang
Yuemin Sun
Weiheng Wu
Feng Liu
Jing Yan
Yinjun Li
Yi Wang
Shouyan Zhang
Changyong Zhou
Hanbin Cui
Jianjun Li
Tianfa Li
Qinghua Han
Yu Wei
Luis Eduardo Echeverria Correa
Jose Luis Accini Mendoza
Fernando Manzur Jattin
Wilder Castaño Osorio
Carlos Alberto Luengas
Julian Alonso Coronel Arroyo
Miguel Alfredo Moncada Corredor
Clara Ines Saldarriaga Giraldo
Rodrigo Botero Lopez
Dora Ines Molina Salazar
Miguel Urina Triana
Luis Horacio Atehortua Lopez
Pastor Olaya Rojas
Sebastian Velez Pelaez
Monica Lopez Pareja
Alberto Cadena Bonfanti
Rostislav Polasek
Zdenek Monhart
Karel Sochor
Zuzana Motovska
Jan Belohlavek
Ladislav Busak
Jiri Krupicka
Petr Tyl
Ondrej Jerabek
Ivo Podpera
Janka Skrobakova
Karel Peterka
Rudolf Spacek
Vladimir Cech
Ivana Kellnerova
Libor Nechvatal
Zbynek Pozdisek
Marek Houra
Radim Kryza
Vilma Machova
Michal Cepelak
David Stepek
Kamil Zeman
Zdenek Klimsa
Pavel Koleckar
Alexandr Schee
Lenka Spinarova
Zdenek Coufal
Jorgen Jeppesen
Soren Vraa
Henrik Wiggers
Ole Nyvad
Tonny Nielsen
Peter Kaiser-Nielsen
Lars Videbaek
Michel Galinier
Jean‐Marie Lefebvre
Jean‐Michel Tartiere
Guillaume De Geeter
Francois Roubille
Jean Etienne Ricci
Muriel Salvat
Jean‐Pierre Gueffet
Eric Decoulx
Philippe Berdague
Guillaume Jondeau
Michel Ovize
Pascal De Groote
Erwan Donal
Richard Isnard
Rémi Sabatier
Jean Noel Trochu
Thibaud Damy
Jean‐Louis Georges
Yann Rosamel
François Picard
Victor Aboyans
Thierry Laperche
Veselin Mitrovic
Jens Taggeselle
Stefan Störk
Henning Ebelt
Sabine Genth-Zotz
Tienush Rassaf
Hans‐Dirk Duengen
Marcus Mittag
Niels Menck
Uwe Zeymer
Stephan Haehling
Michael Boehm
Lutz Frankenstein
Holger Killat
Hakima Bourhaial
Daniel Beug
Thomas Horacek
Roman Pfister
Marcus Sandri
Ralf Westenfeld
Christoph Kadel
Haralambos Karvounis
Sotirios Patsilinakos
Ioannis Mantas
Apostolos Karavidas
Grigorios Giamouzis
Konstantinos Tsioufis
Katerina Naka
Dimitrios Tziakas
John Parissis
Ioannis Styliadis
Ioannis Barbetseas
Athanasios Manolis
George Kochiadakis
Bela Herczeg
Laszlo Nagy
Noemi Nyolczas
Kalman Toth
Bela Merkely
Zoltan Laszlo
Laszlo Mark
Imre Szakal
Andras Papp
Katalin Bezzegh
Ferenc Lakatos
Erik Hajko
Aniko Papp
Tamas Forster
Geza Lupkovics
Attila Mohacsi
Csaba Salamon
Daniel Aradi
Peter Andreka
Gyula Szasz
Zsolt Zilahi
Rita Kazinczy
Alberto Margonato
Piergiuseppe Agostoni
Alessandro Fucili
Giancarlo Piovaccari
Michele Senni
Erberto Carluccio
Claudio Bilato
Maria Frigerio
Ciro Indolfi
Gianfranco Sinagra
Natale Daniele Brunetti
Gianpiero Perna
Daniela Pini
Maurizio Volterrani
Sergio Leonardi
Andrea Mortara
Hernan Emilio Francisco Polo Friz
Roberta Rossini
Carlo Gabriele Tocchetti
Antonella Vincenzi
Claudio Cavallini
Agata Marina Floresta
Valerio Zaca
Vittorio Giudici
Giovanni Quinto Villani
Yorihiko Higashino
Shogo Oishi
Atsuyuki Wada
Shigeru Fukuzawa
Kenji Onoue
Akihiro Koike
Tomomi Koizumi
Seigo Masuda
Kazuhisa Mitsuo
Natsuki Takahashi
Takashi Takenaka
Jun Tanabe
Naoki Watanabe
Takeshi Yoshida
Tetsuya Amano
Masahiro Ishikawa
Keisuke Kida
Toru Kubota
Kentaro Nakamura
Tomohiro Sakamoto
Mitsuhiro Shimomura
Masaru Yuge
Masayuki Doi
Hiroshi Domae
Mio Ebato
Kenshi Fujii
Wakaya Fujiwara
Seiichiro Gohara
Yoshiki Hata
Junji Kanda
Hiroaki Kitaoka
Takashi Matsumoto
Ichiro Michishita
Shinichiro Miura
Tetsuro Miyazaki
Akihiro Nakamura
Tomohiro Ogawa
Takahiro Okumura
Yasuo Okumura
Tetsuo Sakai
Yukihito Sato
Wataru Shimizu
Hiroshi Sugino
Masahiro Suzuki
Atsutoshi Takagi
Hiroshi Takaishi
Takahiro Tanaka
Toshiro Terasaki
Mitsuru Tsujimoto
Yasunori Ueda
Keiji Ujino
Makoto Usui
Mitsutaka Yamamoto
Masaki Yoshikawa
Kenji Ando
Masanori Asakura
Hiroshi Asano
Shigeru Fujii
Hisao Hara
Takayuki Inomata
Takaaki Isshiki
Toshiaki Kadokami
Hisashi Kai
Toshio Kasai
Katsunori Kawamitsu
Tomohiro Kawasaki
Tokushi Koga
Nobuyuki Komiyama
Yasuhiro Maejima
Mamoru Manita
Nobuhide Miyamoto
Koichi Node
Kotaro Numaguchi
Yasushi Sakata
Takeshi Serikawa
Noriaki Takama
Shunsuke Tatebe
Hideki Ueno
Takayuki Hidaka
Shitoshi Hiroi
Harukazu Iseki
Hiroshi Ito
Kouji Kajinami
Hideo Kawakami
Yukihiko Momiyama
Masuki Mori
Yukiko Morita
Kaoru Okishige
Satoru Sakagami
Yasuchika Takeishi
Akihiro Terasawa
Noriaki Utsu
Jolita Badariene
Jelena Celutkiene
Rimvydas Slapikas
Dalia Jarasuniene
Armando Garcia Castillo
Manuel Odin De los Rios Ibarra
Gabriel Arturo Ramos Lopez
Edmundo Alfredo Bayram Llamas
Guillermo Antonio Llamas Esperon
Eduardo Salcido Vazquez
Ricardo Garcia Gonzalez
Jose Luis Arenas Leon
Salvador Leon Gonzalez
Maria Alexandra Arias Mendoza
Alicia Contreras Rodriguez
Gustavo Francisco Mendez Machado
Melchor Alpizar Salazar
Alberto Esteban Bazzoni Ruiz
Ana Maria De Leon Flores
Jose Alfredo Pagola Carrasco
Raul Reyes Araiza
Tjeerd Römer
Johannes Remmen
Jacob Van Eck
Arif Elvan
Tom Smilde
Adriaan Voors
Ruud Wal
Jeroen Schaap
Aize Sluis
Gerardus Linssen
Michael Magro
Frank Willems
John Hal
Coenraad Zwaan
Driek Beelen
Dirk Boswijk
Walter Hermans
Henricus Van Kesteren
Russell Scott
Hamish Hart
Marianne Lund
Marcin Szczasny
Tomasz Blicharski
Mariusz Kafara
Anna Stankiewicz
Grzegorz Skonieczny
Maciej Zabowka
Grzegorz Kania
Jerzy Kopaczewski
Lidia Pawlowicz
Janusz Spyra
Aleksander Wlodarczyk
Ryszard Sciborski
Pawel Balsam
Jaroslaw Drozdz
Bozena Sobkowicz
Malgorzata Konieczynska
Malgorzata Lelonek
Zbigniew Bednarkiewicz
Jaroslaw Trebacz
Piotr Jankowski
Mateusz Sidor
Piotr Berkowski
Zbigniew Chmielak
Lucyna Lenartowska
Jadwiga Nessler
Ewa Straburzynska-Migaj
Zbigniew Kalarus
Robert Kowalski
Ewa Kalecinska-Krystkiewicz
Zbigniew Gola
Zbigniew Pijanowski
Beata Wozakowska-Kaplon
Krzysztof Cymerman
Andrzej Rynkiewicz
Pawel Miekus
Pedro Monteiro
Pedro Morais Sarmento
Filipa Almeida
Tatiana Duarte
Candida Fonseca
Luis Oliveira
Luis Santos
Dulce Brito
Gabriela Stanciulescu
Marilena Renata Spiridon
Constantin Militaru
Cristian Gheorghe Podoleanu
Dumitru Zdrenghea
Mircea Ioachim Popescu
Cezar‐Eugen Macarie
Alina Giuca
Florin Mitu
Olga‐Cristina Voicu
Maria Dorobantu
Daniel Lighezan
Sorin Stamate
Alexander Bykov
Zhanna Kobalava
Konstantin Zrazhevskiy
Irina Semenova
Alexander Vishnevsky
Elena Shutemova
Sergey Tereschenko
Yury Shvarts
Olga Barbarash
Yury Lukyanov
Mikhail Voevoda
Svetlana Dovgolis
Dmitry Dronov
Boris Goloshchekin
Maria Sitnikova
Marat Ezhov
Nikolay Tarasov
Mikhail Kotelnikov
Viktor Kostenko
Oleg Solovev
Ivan Goncharov
Roman Myasnikov
Vladimir Rafalskiy
Vyacheslav Ryabov
Elena Kosmacheva
Igor Motylev
Vladimir Nosov
Irina Osipova
Vladimir Salukhov
Dmitriy Belenkiy
Olga Bolshakova
Leonid Pimenov
Nataliya Shilkina
Elena Kulibaba
Alexey Repin
Alexander Timofeev
Vladislav Mitrokhin
Alexander Sherenkov
Georgy Arbolishvili
Lubomir Antalik
Andrej Dzupina
Peter Fulop
Ivan Majercak
Jozef Gonsorcik
Daniela Vinanska
Egon Lenner
Jana Lukacova
Roman Margoczy
Rudolf Smik
Jan Stevlik
Rudolf Uhliar
Lesley Burgess
Aysha Badat
Eric Klug
Louis Van Zyl
Mark Abelson
Rajendran Moodley
Nqoba Tsabedze
Nyda Fourie
Luis Almenar Bonet
Jose Maria Arizon Prado
Manue Martinez‐Selles D Oliveira Soares
Julio Eduardo Nuñez Villota
Maria Generosa Crespo Leiro
Jose Ramon Gonzalez Juanatey
Domingo Andres Pascual Figal
Juan Luis Bonilla Palomas
Sonia Mirabet Perez
Juan Francisco Delgado Jimenez
Antonio Lara Padron
Victor Alfonso Jimenez Diaz
Javier Segovia Cubero
Vicente Eduardo Climent Paya
Alejandro Recio Mayoral
Luis Fuente Galan
Juan Jose Gomez Doblas
Ramon Bover Freire
Maria Teresa Blasco Peiro
Beatriz Diaz Molina
Laura Jordan Martinez
Francisco Gonzalez Vilchez
Kurt Boman
Patric Karlstrom
Stefan Berglund
Barna Szabo
Magnus Peterson
Peter Wodlin
Carl‐Johan Lindholm
Tiziano Moccetti
Christian Mueller
Thomas Suter
Roger Hullin
Philippe Meyer
Georg Noll
Zerrin Yigit
Okan Onur Turgut
Lutfu Bekar
Tayfun Sahin
Zehra Lale Koldas
Ahmet Celik
Yuksel Cavusoglu
Mesut Demir
Ersel Onrat
Mehmet Duzenli
Kahraman Cosansu
Ibrahim Haldun Muderrisoglu
Mustafa Tuncer
Ozer Badak
Sanem Nalbantgil
Cevat Kirma
Ertugrul Okuyan
Umit Guray
Oleksandr Prokhorov
Oleksandr Karpenko
Igor Vakaliuk
Andriy Yagensky
Igor Kracz
Mykola Stanislavchuk
Oleksii Kulynych
Mykola Rishko
Roman Stets
Vira Tseluyko
Larysa Mishchenko
Leonid Rudenko
Iurii Rudyk
Liudmyla Alieksieieva
Oleksii Korzh
Yuriy Mostovoy
Oleksandr Parkhomenko
Lesya Rasputina
Leonid Voronkov
Yurii Lymar
Larysa Vasilyeva
Philip Keeling
Craig Barr
Kenneth Wong
Dallas Price
Binoy Skaria
Andrew Clark
Badrinathan Chandrasekaran
Jasper Trevelyan
Brian Gordon
Patrick Donnelly
Jason Glover
Alisdair Ryding
Robin Weir
Chim Lang
Debashis Roy
Shaumik Adhya
Piers Clifford
Andrew Ludman
Paul Kalra
Mary Lynch
Shahid Mahmood
Abdallah Al Mohammad
Joshua Asubiaro
Einas Elmahi
Amal Muthumala
Justin Taylor
Dinesh Gupta
Venkatesh Nadar
David Henderson
Ronald Zolty
Andrew Sauer
Kirkwood Adams
Lokesh Chandra
Naseem Jaffrani
Gurinder Grewal
Donna Mancini
Dalton McLean
Javier Vasallo
Stephen Gottlieb
Susan Joseph
Rajat Barua
Eiran Gorodeski
Asad Mouhaffel
Eugene Chung
Pratik Desai
Edward Portnay
Bhola Rama
Adrian Shandling
Llyod Stahl
Karl Heilman
Binu Jacob
Juan Londono
Omar Almousalli
Thomas Ashcom
Eugene Joseph Bauerlein
Charles Koo
Frank McGrew
Navin Rajagopalan
Shawn Robinson
David Schultz
Randall Starling
Amrut Ambardekar
Ravi Bhagwat
John Boehmer
Manuel Bouza
Neil Farris
Scott Feitell
Jagadeesh Ganji
Edward Geltman
Julian Javier
John Andrew Morrow
Leonard Pianko
Frank Smart
Alexander Adler
Douglas Brinkley
Jose Cardona
Andrew Coletti
John Harris
Vernon Hunter
Mori Krantz
Christopher Lang
Charles Lovell
David Murray
Priya Pillutla
Amit Shah
Roberta Bogaev
Ira Dauber
Francesco Franchi
Richard Fremont
Terence Hart
Brack Hattler
Matthew Janik
Wissam Khalife
Sanjay Malhotra
Shafiq Mamdani
William Nelson
Marisa Orgera
Aurelio Ortiz
Peter Rahko
Stephen Rennyson
Jooyoung Shin
Lana Tsao
Barry Uretsky
Faisal Wahid
Matt Wilkett
Aman Amanullah
Mathue Baker
Martin Berk
Fernando Boccalandro
Kimberly Cruz
Timothy Doyle
Robert Gianfagna
Alonzo Jones
Anthony King
Norman Lepor
Melvin Martinez-Castrillon
Michael Pham
Michael Radin
Joseph Radojevic
Kodangudi Ramanathan
Carsten Schmalfuss
Robert Schnitzler
Keyur Shah
Theodore Takata
Barry Bertolet
Brian Bostick
Andrew Civitello
John Collins
Nabil Dib
James Fang
Richard Gilmore
Wayne Gray
Luanda Grazette
Tariq Haddad
Steven Hearne
Munir Janmohamed
Richard Katz
Navid Kazemi
Sara Llerena
Nicole Lohr
George Marzouka
John Mignone
Henry Ooi
Anna Paszczuk
Christopher Pickett
Gregory Sampognaro
Douglas Sawyer
Steven Shayani
Charles Treasure
Garth Vaz
Nampalli Vijay
Celeste Williams
Gary Yeoman
Lily Zhang
Keith Aaronson
Wael Abo-Auda
Rami Alharethi
William Anderson
Mehrdad Ariani
Sourin Banerji
Paramdeep Baweja
Peter Carson
Arthur Eberly
James Elliott
Ronald Fernando
Daniel Fisher
Steven Forman
George Gabriel
Harinder Gogia
Craig Hametz
Brian Houston
Hassan Ibrahim
Farid Jadbabaie
Christos Kassiotis
Arun Krishnamoorthy
Michael Kwan
Steven Lupovitch
Leonardo Macias
Adnan Malik
Luis Martinez
Michael Miyamoto
Freny Mody
Devesh Patel
Brenda Peart
Barbara Pisani
Mark Ramos
Mariel Rivero
Anil Shah
Mukesh Sharma
Tina Sichrovsky
Marc Simon
Deovrat Singh
Julio Tallet
Christopher Vaccari
Mario Villoch
Matthew Wheeler
Kabir Yousuf
Rafik Abadier
Shuaib Abdullah
Raveen Arora
Shamaila Aslam
Robert Buynak
David Chang
Johanna Contreras
Stephen Halpern
Franklin Handel
John Heitner
William Herzog
Bruce Jackson
John Kao
Nicholas Kondo
Michael Koren
Martin LeWinter
Jeffrey Martindale
Joaquin Martinez-Arraras
Stephanie Olsen
Marek Piatek
Nandkishore Ranadive
William Randall
Sunder Rao
David Rawitscher
James Rider
George Sokos
J Russell Strader
Nasir Sulemanjee
Naeem Tahirkheli
Benjamin Trichon
Thomas Vanhecke
David Whellan
Mohammad Abuannadi
Gaurav Aggarwala
Saad Ahmad
Andre Artis
Jorge Cheirif
Vladimir Cotarlan
Jeremy Cox
Charles Eaton
Viorel Florea
Theodore Frank
Keith Friedman
Vedampattu Ganeshram
Alan Gass
Anthony Gemignani
Syed Hasni
Chester Hedgepeth
Dipti Itchhaporia
Edo Kaluski
Amin Karim
Alan Kono
Ellis Lader
Batlagundu Lakshminarayanan
Neil Lewis
Vinay Malhotra
Nolan Mayer
Robert Mohapatra
Nandini Nair
Terrence O'Brien
Sunil Pauwaa
Christopher Rowan
Sanjeev Saxena
Arnold Seto
Nishant Shah
Pradeep Singh
Hal Skopicki
Marcus Stoddard
Nancy Sweitzer
Éditeur: Wiley
Identifiants: 99158897809311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article