Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Sylvie Pochet; Laurence Dugué; Dominique Douguet; Gilles Labesse; Hélène Munier-Lehmann

doi:10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B

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Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Journal article

Peer reviewed

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Sylvie Pochet, Laurence Dugué, Dominique Douguet, Gilles Labesse and Hélène Munier-Lehmann

ChemBioChem, Vol.3(1), pp.108-10

04/01/2002

DOI: https://doi.org/10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B

PMID: 17590962

Abstract

Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs. A modeling and docking study was used to rationalize the experimental data.

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Title: Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.
Creators - without role: Sylvie Pochet - Institut Pasteur
Laurence Dugué - Institut Pasteur
Dominique Douguet - Université de Montpellier, Centre de Biologie Structurale - CBS
Gilles Labesse - Université de Montpellier, Centre de Biologie Structurale - CBS
Hélène Munier-Lehmann - Institut Pasteur
Publication Details: ChemBioChem, Vol.3(1), pp.108-10
Identifiers: 9945176909311
Academic Unit: Centre de Biologie Structurale - CBS
Language: English
Resource Type: Journal article
Local Fields: pasteur-00166196