Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model

Philipp Spatz; Thomas Zimmermann; Sophie Steinmüller; Julian Hofmann; Tangui Maurice; Michael Decker

doi:10.1039/d2md00087c

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Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model

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Peer reviewed

Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model

Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice and Michael Decker

RSC Medicinal Chemistry, Vol.13(8), pp.944-954

17/08/2022

DOI: https://doi.org/10.1039/d2md00087c

PMCID: PMC9384809

Abstract

Benzimidazole-based inhibitors of butyrylcholinesterase were designed and tested for their activity and selectivity in vitro , leading to compound (11d) that attenuated Aβ 25-35 -induced learning impairments in an Alzheimer's disease mouse model.

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Title: Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model
Creators - without role: Philipp Spatz - University of Würzburg
Thomas Zimmermann - University of Würzburg
Sophie Steinmüller
Julian Hofmann - University of Würzburg
Tangui Maurice - Université de Montpellier, Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Michael Decker - University of Würzburg
Publication Details: RSC Medicinal Chemistry, Vol.13(8), pp.944-954
Identifiers: 9941141909311
Academic Unit: Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Language: English
Resource Type: Journal article
Local Fields: hal-04267435